cIAP2 as a therapeutic target in colorectal cancer and other malignancies

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Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer

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Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

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de la Chapelle, A.

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

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Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal Cancer

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Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

2007 • 1,166 citations

cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

2008 • 1,034 citations

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1996 • 1,027 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

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The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

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Cell Death Independent of Caspases: A Review

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Structural basis of IAP recognition by Smac/DIABLO

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The Apoptosis Inhibitor Gene API2 and a Novel 18q Gene,MLT, Are Recurrently Rearranged in the t(11;18)(q21;q21) Associated With Mucosa-Associated Lymphoid Tissue Lymphomas

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Randomised comparison of combination chemotherapy plus supportive care with supportive care alone in patients with metastatic colorectal cancer.

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A Small Molecule Smac Mimic Potentiates TRAIL- and TNFα-Mediated Cell Death

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Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

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Inhibition of apoptosis during development of colorectal cancer.

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The inhibitors of apoptosis (IAPs) as cancer targets

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The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

2001 • 514 citations

IAP-targeted therapies for cancer

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Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation

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The alternative NF-κB pathway from biochemistry to biology: Pitfalls and promises for future drug development

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NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

1999 • 339 citations

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis

2008 • 244 citations

The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer

2007 • 208 citations

Apaf-1/Cytochrome c-independent and Smac-dependent Induction of Apoptosis in Multiple Myeloma (MM) Cells

2001 • 202 citations

Design, Synthesis, and Characterization of a Potent, Nonpeptide, Cell-Permeable, Bivalent Smac Mimetic That Concurrently Targets Both the BIR2 and BIR3 Domains in XIAP

2007 • 194 citations

SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

2008 • 191 citations

Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo

2005 • 185 citations

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.

1999 • 178 citations

Phase I Study of YM155, a Novel Survivin Suppressant, in Patients with Advanced Solid Tumors

2009 • 173 citations

Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs

2006 • 172 citations

Colon cancer and apoptosis

2006 • 158 citations

Antiadult T‐cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol

2008 • 133 citations

Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis

2007 • 131 citations

Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis

2006 • 130 citations

IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes

2006 • 116 citations

Survivin Antisense Oligonucleotides Effectively Radiosensitize Colorectal Cancer Cells in Both Tissue Culture and Murine Xenograft Models

2008 • 109 citations

MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), Amplified on Chromosome 9, Collaborate with p53 Deficiency in Mouse Osteosarcoma Progression

2009 • 98 citations

Analysis of Apoptosis Protein Expression in Early-Stage Colorectal Cancer Suggests Opportunities for New Prognostic Biomarkers

2005 • 92 citations

A Small Molecule Ubiquitination Inhibitor Blocks NF-κB-dependent Cytokine Expression in Cells and Rats

2002 • 82 citations

Expression and localization of inhibitor of apoptosis proteins in normal human tissues

2005 • 74 citations

Expression of IAP family proteins in colon cancers from patients with different age groups

2004 • 65 citations

Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin Suppressant

2009 • 56 citations

Down‐regulation of cIAP2 enhances 5‐FU sensitivity through the apoptotic pathway in human colon cancer cells

2009 • 56 citations

The RING Domain of cIAP1 Mediates the Degradation of RING-bearing Inhibitor of Apoptosis Proteins by Distinct Pathways

2008 • 55 citations

Recurrent Overexpression of c-IAP2 in EBV-Associated Nasopharyngeal Carcinomas: Critical Role in Resistance to Toll-like Receptor 3-Mediated Apoptosis

2008 • 51 citations

Cytoprotective effects of IAPs revealed by a small molecule antagonist

2008 • 50 citations

Potent, Orally Bioavailable Diazabicyclic Small-Molecule Mimetics of Second Mitochondria-Derived Activator of Caspases

2008 • 50 citations

Phenoxodiol: pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs

2009 • 45 citations

Activation of c-MYC and c-MYB proto-oncogenes is associated with decreased apoptosis in tumor colon progression.

2002 • 44 citations

Structural Basis for Bivalent Smac-Mimetics Recognition in the IAP Protein Family

2009 • 44 citations

Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2

1999 • 42 citations

Design, Synthesis, and Evaluation of Potent, Nonpeptidic Mimetics of Second Mitochondria-Derived Activator of Caspases

2009 • 38 citations

Dealing the CARDs between life and death

2001 • 32 citations

Flavonoids, phenoxodiol, and a novel agent, triphendiol, for the treatment of pancreaticobiliary cancers

2009 • 30 citations

Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells

2008 • 29 citations

Subcellular Expression of c-IAP1 and c-IAP2 in Colorectal Cancers: Relationships with Clinicopathological Features and Prognosis

2003 • 28 citations

Involvement of Human Organic Cation Transporter 1 in the Hepatic Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel, Small Molecule Survivin Suppressant

2009 • 18 citations

Smac-mediated sensitization of human B-lymphoma cells to staurosporine- and lactacystin-triggered apoptosis is apoptosome-dependent

2007 • 13 citations

Expression of Bcl-XS alters cytokinetics and decreases clonogenic survival in K12 rat colon carcinoma cells

1998 • 12 citations