Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload.

Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.

1991 • 1,358 citations

Purification and complete amino acid sequence of α-human atrial natriuretic polypeptide (α-hANP)

1984 • 1,153 citations

Atrial Natriuretic Peptide Elevation in Congestive Heart Failure in the Human

1986 • 882 citations

The amino acid sequence of an atrial peptide with potent diuretic and natriuretic properties

1983 • 743 citations

Atrial natriuretic factor in normal subjects and heart failure patients. Plasma levels and renal, hormonal, and hemodynamic responses to peptide infusion.

1986 • 711 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Different secretion patterns of atrial natriuretic peptide and brain natriuretic peptide in patients with congestive heart failure.

1993 • 619 citations

Increased plasma levels of brain natriuretic peptide in patients with acute myocardial infarction.

1993 • 590 citations

Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. Possible existence of "vascular natriuretic peptide system".

1992 • 528 citations

Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.

1991 • 505 citations

Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response.

1990 • 444 citations

Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation.

1991 • 437 citations

Rapid Ventricular Induction of Brain Natriuretic Peptide Gene Expression in Experimental Acute Myocardial Infarction

1995 • 435 citations

Molecular biology and biochemistry of the natriuretic peptide system. II: Natriuretic peptide receptors

1992 • 427 citations

Hemodynamic, renal, and hormonal responses to brain natriuretic peptide infusion in patients with congestive heart failure.

1991 • 421 citations

ATRIAL NATRIURETIC FACTOR AND RELATED PEPTIDE HORMONES

1991 • 368 citations

Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1 β in Rat Aortic Smooth Muscle Cells

1995 • 347 citations

Clinical application of atrial natriuretic polypeptide in patients with congestive heart failure: beneficial effects on left ventricular function.

1987 • 344 citations

Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells.

1990 • 327 citations

mRNA decay: Finding the right targets

1989 • 318 citations

Neonatal atria and ventricles secrete atrial natriuretic factor via tissue-specific secretory pathways

1986 • 283 citations

Natriuretic peptides as cardiac hormones in normotensive and spontaneously hypertensive rats. The ventricle is a major site of synthesis and secretion of brain natriuretic peptide.

1991 • 273 citations

A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription.

1994 • 271 citations

Potent and Specific Inhibitors of Protein Kinase C of Microbial Origin

1990 • 262 citations

Expression of brain natriuretic peptide gene in human heart. Production in the ventricle.

1991 • 251 citations

Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression.

1991 • 244 citations

Augmented expression of atrial natriuretic polypeptide gene in ventricle of human failing heart.

1989 • 233 citations

The cardiac beta-myosin heavy chain isogene is induced selectively in alpha 1-adrenergic receptor-stimulated hypertrophy of cultured rat heart myocytes.

1990 • 200 citations

Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene.

1994 • 181 citations

Cloning and sequence analysis of cDNA encoding a precursor for rat brain natriuretic peptide

1989 • 170 citations

Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.

1992 • 170 citations

Increased secretion of atrial natriuretic polypeptide from the left ventricle in patients with dilated cardiomyopathy.

1989 • 135 citations

Regulation of rat brain natriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression.

1994 • 130 citations

Nucleotide sequence of the gene encoding human atrial natriuretic factor precursor

1984 • 129 citations

RAT BRAIN NATRIURETIC PEPTIDE—TISSUE DISTRIBUTION AND MOLECULAR FORM—

1990 • 125 citations

Human and canine gene homologs of porcine brain natriuretic peptide

1989 • 119 citations

Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system.

1994 • 118 citations

Augmented secretion of brain natriuretic peptide in acute myocardial infarction

1991 • 113 citations

Augmented expression of atrial natriuretic polypeptide gene in ventricles of spontaneously hypertensive rats (SHR) and SHR-stroke prone.

1988 • 110 citations

Natriuretic peptide receptor mRNAs in the rat and human heart.

1992 • 103 citations

Differential regulation of skeletal alpha-actin transcription in cardiac muscle by two fibroblast growth factors.

1990 • 103 citations

Synthesis of atrial natriuretic polypeptide in human failing hearts. Evidence for altered processing of atrial natriuretic polypeptide precursor and augmented synthesis of beta-human ANP.

1988 • 101 citations

Brain natriuretic peptide is induced by alpha 1-adrenergic agonists as a primary response gene in cultured rat cardiac myocytes

1994 • 97 citations

Cis-acting sequences that modulate atrial natriuretic factor gene expression.

1988 • 85 citations

A Hormone-Encoding Gene Identifies a Pathway for Cardiac but Not Skeletal Muscle Gene Transcription

1994 • 75 citations

Divergent Regulation of the Human Atrial Natriuretic Peptide Gene by c-jun and c-fos

1992 • 68 citations

Isolation and sequence determination of rat cardiac natriuretic peptide

1989 • 62 citations

Heart myosin light chain 2 gene. Nucleotide sequence of full length cDNA and expression in normal and hypertensive rat.

1986 • 61 citations

Proximal regulatory domains of rat atrial natriuretic factor gene.

1991 • 52 citations

Divergent regulation of the human atrial natriuretic peptide gene by c-jun and c-fos.

1992 • 51 citations

Upstream sequences confer atrial-specific expression on the human atrial natriuretic factor gene.

1988 • 49 citations

Tissue-specific Determinants of Human Atrial Natriuretic Factor Gene Expression in Cardiac Tissue

1989 • 49 citations

Phorbol ester stimulates the synthesis and secretion of brain natriuretic peptide from neonatal rat ventricular cardiocytes: a comparison with the regulation of atrial natriuretic factor.

1993 • 38 citations

Cis-Active Determinants of Cardiac-Specific Expression in the Human Atrial Natriuretic Peptide Gene

1991 • 35 citations

Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides.

1994 • 32 citations

Concentration and molecular forms of brain natriuretic peptide in rat plasma and spinal cord

1991 • 26 citations

Differential regulation of the expression of fast-type sarcoplasmic-reticulum Ca2+-ATPase by thyroid hormone and insulin-like growth factor-I in the L6 muscle cell line

1994 • 20 citations

Atrial Natriuretic Factor And Related Peptide Hormones

1991 • 20 citations

Phorbol ester stimulates the synthesis and secretion of brain natriuretic peptide from neonatal rat ventricular cardiocytes: a comparison with the regulation of atrial natriuretic factor

1993 • 11 citations

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