The assessment of cellular proliferation by immunohistochemistry: A review of currently available methods and their applications

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

1984 • 4,180 citations

Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation

1983 • 2,745 citations

Monoclonal Antibody to 5-Bromo- and 5-Iododeoxyuridine: A New Reagent for Detection of DNA Replication

1982 • 2,648 citations

Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ

1987 • 1,766 citations

Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms

1990 • 1,454 citations

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary protein

1987 • 1,074 citations

Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites.

1987 • 945 citations

Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67.

1991 • 891 citations

Autoantibody to a Nuclear Antigen in Proliferating Cells

1978 • 881 citations

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA) structural conservation and the detection of a nucleolar form

1990 • 736 citations

Growth Kinetics of Tumours

1978 • 691 citations

Monoclonal antibody Ki‐67: its use in histopathology

1990 • 655 citations

Stem cells: the generation and maintenance of cellular diversity

1989 • 504 citations

An auxiliary protein for DNA polymerase-delta from fetal calf thymus.

1986 • 500 citations

Review: assessment of cell proliferation in histological material.

1990 • 456 citations

Regulation of Proliferating Cell Nuclear Antigen during the Cell Cycle

1989 • 447 citations

The biology of epithelial cell populations

1984 • 339 citations

Bromodeoxyuridine in tumors and chromosomes detected with a monoclonal antibody.

1983 • 337 citations

A nuclear antigen associated with cell proliferation and blast transformation.

1981 • 333 citations

The prognostic value of Ki67 immunostaining in non‐Hodgkin's lymphoma

1988 • 314 citations

Measurement of cell kinetics in human tumours in vivo using bromodeoxyuridine incorporation and flow cytometry

1988 • 310 citations

Nuclear incorporation of P as demonstrated by autoradiographs

1951 • 302 citations

Cyclin/PCNA immunostaining as an alternative to tritiated thymidine pulse labelling for marking S phase cells in paraffin sections from animal and human tissues

1989 • 295 citations

A comparison of immunohistochemical markers of cell proliferation with experimentally determined growth fraction

1991 • 285 citations

Changes in the nuclear distribution of cyclin (PCNA) but not its synthesis depend on DNA replication.

1985 • 284 citations

Monoclonal antibodies to a nuclear protein (PCNA/cyclin) associated with DNA replication

1987 • 268 citations

Ki-67 detects a nuclear matrix-associated proliferation-related antigen: II. Localization in mitotic cells and association with chromosomes

1989 • 263 citations

Correlation between DNA flow cytometric and nucleolar organizer region data in non‐Hodgkin's lymphomas

1988 • 256 citations

Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables

1987 • 253 citations

A comparison of nucleolar organizer region staining and Ki‐67 immunostaining in non‐Hodgkin's lymphoma

1988 • 248 citations

Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesis.

1988 • 248 citations

The Biology of Epithelial Cell Populations

1985 • 246 citations

DNA repair synthesis in human fibroblasts requires DNA polymerase delta.

1988 • 245 citations

Regulation of the proliferating cell nuclear antigen cyclin and thymidine kinase mRNA levels by growth factors.

1988 • 235 citations

The cell cycle associated change of the Ki‐67 reactive nuclear antigen expression

1987 • 228 citations

Ki-67 detects a nuclear matrix-associated proliferation-related antigen : I. Intracellular localization during interphase

1989 • 223 citations

The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S + G2 + M phase fraction (flow cytometric analysis) and prognosis

1991 • 220 citations

A Stem Cell Model of Human Tumor Growth: Implications for Tumor Cell Clonogenic Assays<xref ref-type="fn" rid="FN2">2</xref>

1983 • 190 citations

Prognostic value of proliferating cell nuclear antigen in gastric carcinoma.

1991 • 190 citations

Relationship between labeling indices of KI-67 and brdurd in human malignant tumors

1988 • 177 citations

Increased nuclear cyclin/PCNA antigen staining of non S‐phase transformed human amnion cells engaged in nucleotide excision DNA repair

1986 • 172 citations

ON THE CONCEPT OF THE CELL CYCLE.

1963 • 160 citations

Haemangiopericytomas: the prognostic value of immunohistochemical staining with a monoclonal antibody to proliferating cell nuclear antigen (PCNA)

1991 • 151 citations

Determination of the growth fraction in cell suspensions by flow cytometry using the monoclonal antibody Ki-67

1986 • 150 citations

Unraveling of mitotic control mechanisms

1988 • 150 citations

Histochemistry in Pathology

1990 • 145 citations

Transcriptional and posttranscriptional regulation of the proliferating cell nuclear antigen gene.

1990 • 143 citations

The Cell Cycle

1981 • 141 citations

Characterization of a large form of DNA polymerase δ from HeLa cells that is insensitive to proliferating cell nuclear antigen

1989 • 141 citations

Gene for proliferating-cell nuclear antigen (DNA polymerase delta auxiliary protein) is present in both mammalian and higher plant genomes.

1989 • 140 citations

Thymidine labeling index and Ki-67 growth fraction in lesions of the breast.

1989 • 138 citations

Commentary dna polymerase δ/PCNA: Actions and interactions

1990 • 136 citations

Ki‐67 derived proliferative activity in colorectal adenocarcinoma with prognostic correlations

1988 • 135 citations

Perspectives on clonogenic tumor cells, stem cells, and oncogenes.

1984 • 133 citations

Nucleolar Organiser Regions

1990 • 121 citations

Protooncogene expression during the cell cycle.

1986 • 116 citations

Comparison of monoclonal antibody Ki-67 reactivity with grade and DNA flow cytometry of breast carcinomas

1988 • 113 citations

New approach to assessing lung tumours in man.

1986 • 113 citations

Simultaneous staining of exponentially growing versus plateau phase cells with the proliferation‐associated antibody Ki‐67 and propidium iodide: analysis by flow cytometry

1987 • 100 citations

Induction of the nuclear protein ‘cyclin’ in quiescent mouse 3T3 cells stimulated by serum and growth factors. Correlation with DNA synthesis.

1984 • 96 citations

An Introduction to Cell Population Kinetics

1978 • 91 citations

Importance of introns in the growth regulation of mRNA levels of the proliferating cell nuclear antigen gene.

1990 • 87 citations

Implications of kinetic heterogeneity in clinical oncology.

1985 • 84 citations

Immunohistologic demonstration of abnormal colonic crypt cell kinetics in ulcerative colitis

1985 • 81 citations

A comparison of three methods for the determination of the growth fraction in non-Hodgkin's lymphoma

1987 • 78 citations

Comparative Analysis of Different Approaches to Investigate Cell Kinetics

1988 • 77 citations

Cell proliferation in non-Hodgkin's lymphomas. Digital image analysis of Ki-67 antibody staining.

1989 • 75 citations

Application of a unique monoclonal antibody as a marker for nonproliferating subpopulations of cells of some tissue.

1985 • 68 citations

Individual nuclei in polykaryons can control cyclin distribution and DNA synthesis.

1985 • 63 citations

Cell cycle-dependent reactivity with the monoclonal antibody Ki-67 during myeloid cell differentiation

1988 • 62 citations

In situ analysis of microvascular pericytes in hypertensive rat brains

1988 • 58 citations

The value of NOR numbers in neoplastic and non‐neoplastic epithelium of the stomach

1989 • 51 citations

Immunocytochemical evaluation of the percentage of proliferating cells in pathological bone marrow and peripheral blood samples with the Ki‐67 and anti‐bromo‐deoxyuridine monoclonal antibodies

1988 • 47 citations

Transcriptional and Posttranscriptional Regulation of the Proliferating Cell Nuclear Antigen Gene

1990 • 45 citations

DIAGNOSIS OF REJECTION IN RENAL ALLOGRAFT BIOPSIES USING THE PRESENCE OF ACTIVATED AND PROLIFERATING CELLS

1989 • 44 citations

The value of nucleolar organizer region staining in the differential diagnosis of borderline melanocytic lesions

1989 • 42 citations

Quantitation of estrogen receptor content and Ki-67 staining in breast carcinoma by the microTICAS image analysis system.

1987 • 41 citations

Quantitation and Estimation of Lymphocyte Subsets in Tissue Section: Comparison with Flow Cytometry

1987 • 40 citations

A critical evaluation of AgNOR counting in benign naevi and malignant melanoma

1991 • 36 citations

Immunodetection in fine-needle aspirates and multiparametric (SAMBA) image analysis. Receptors (monoclonal antiestrogen and antiprogesterone) and growth fraction (monoclonal Ki67) evaluation in breast carcinomas

1989 • 34 citations

Nucleolar organizer regions in gastric carcinoma and its precursor stages

1990 • 34 citations

Comparative analysis of [³H]‐thymidine labelling index and monoclonal antibody Ki‐67 in non‐Hodgkin's lymphomas

1988 • 33 citations

Cell Kinetic Study of Human Carcinomas Using Bromodeoxyuridine

1988 • 28 citations

The differentiation process of intestinal epithelial cells is associated with the appearance of statin, a non-proliferation-specific nuclear protein

1990 • 21 citations

Importance of Introns in the Growth Regulation of mRNA Levels of the Proliferating Cell Nuclear Antigen Gene

1990 • 20 citations

The distribution and kinetics of nuclei in rat osteoclasts

1987 • 13 citations

COMMENTARY DNA polymerase d/PCNA: actions and interactions

1990 • 11 citations

A simple and rapid method for the identification of cycling cells in freshly excised tumours.

1985 • 8 citations

A simple and rapid method for the identification of cycling cells in freshly excised tumours.

1985 • 5 citations