Neuroendocrine differentiation in carcinoma of the prostate. Diagnostic, prognostic, and therapeutic implications

Physiology of the Gastrointestinal Tract.

1987 • 1,948 citations

THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT

1969 • 1,680 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1985 • 1,360 citations

Carcinoid TumorsAn analysis of 2837 cases

1975 • 1,118 citations

Treatment of the Malignant Carcinoid Syndrome

1986 • 852 citations

Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin. Evidence of major therapeutic activity in the anaplastic variants of these neoplasms

1991 • 843 citations

Carcinoma of the Prostate

1991 • 755 citations

Streptozocin Alone Compared with Streptozocin plus Fluorouracil in the Treatment of Advanced Islet-Cell Carcinoma

1980 • 638 citations

PATTERNS OF PROGRESSION IN PROSTATE CANCER

1986 • 592 citations

The granin-(chromogranin/secretogranin) family

1991 • 475 citations

Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells

1984 • 354 citations

Ectopic Secretion of Corticotropin-Releasing Factor as a Cause of Cushing’s Syndrome

1984 • 283 citations

Small cell carcinoma of the prostate part I a clinicopathologic study of 20 cases

1987 • 272 citations

Streptozocin plus fluorouracil versus doxorubicin therapy for metastatic carcinoid tumor.

1984 • 262 citations

I. High affinity receptors for bombesin/GRP-like peptides on human small cell lung cancer

1985 • 251 citations

Gastrin-Releasing Peptide (Mammalian Bombesin) Gene Expression in Health and Disease

1989 • 251 citations

Neuroendocrine differentiation in human prostatic carcinoma

1992 • 236 citations

Bombesin stimulates growth of human prostatic cancer cellsin vitro

1990 • 227 citations

RISK RATIOS

1976 • 222 citations

Ectopic ACTH, prostatic oat cell carcinoma, and marked hypernatremia

1977 • 201 citations

The course of neuroendocrine differentiation in prostatic carcinomas

1989 • 188 citations

PLASMA-IMMUNOREACTIVE-CALCITONIN IN PATIENTS WITH NON-THYROID TUMOURS

1974 • 183 citations

Serotonin as a growth factor

1990 • 180 citations

Elevated Plasma Chromogranin-A Concentrations in Prostatic Carcinoma

1991 • 177 citations

Neuroendocrine differentiation in prostatic carcinoma

1987 • 159 citations

Small cell carcinoma of the prostate. II. Immunohistochemical and electron microscopic studies of 18 cases

1987 • 158 citations

[Psi 13,14] bombesin analogues inhibit growth of small cell lung cancerin vitro and in vivo.

1991 • 156 citations

Peptide-Hormone- And Serotonin-Immunoreactive Tumour Cells in Carcinoma of the Prostate

1987 • 148 citations

Neuroendocrine Cells of the Lung an Overview of Morphologic Characteristics and Development

1982 • 145 citations

Argentaffin cells in prostatic carcinoma: Differentiation from lipofuscin and melanin in prostatic epithelium

1971 • 132 citations

Neuropeptides as cellular growth factors: role of multiple signalling pathways

1991 • 131 citations

Peptide-hormone- and serotonin-immunoreactive cells in normal and hyperplastic prostate glands

1986 • 123 citations

Use of serum tumor markers in cancer diagnosis and management.

1987 • 117 citations

Human prostatic endocrine-paracrine (APUD) cells. Distributional analysis with a comparison of serotonin and neuron-specific enolase immunoreactivity and silver stains.

1985 • 117 citations

Human chorionic gonadotropin in human neoplastic cells.

1976 • 111 citations

The histogenesis of small cell carcinoma of the prostate an immunohistochemical study

1984 • 110 citations

Neuropeptides as growth factors. Possible roles in human diseases

1989 • 110 citations

Small Cell Carcinoma of the Genitourinary Tract: An Immunohistochemical, Electron Microscopic and Clinicopathological Study

1991 • 109 citations

Gamma-subunit of the glycolytic enzyme enolase: nonspecific or neuron specific?

1985 • 106 citations

Somatostatin analogs as adjuncts to agonists of luteinizing hormone-releasing hormone in the treatment of experimental prostate cancer.

1987 • 104 citations

A somatostatin analogue inhibits chondrosarcoma and insulinoma tumour growth

1985 • 104 citations

Neuroendocrine differentiation in prostatic carcinomas. A retrospective autopsy study.

1988 • 101 citations

Evaluation of serum neuron-specific enolase as a tumor marker for carcinoma of the lung.

1983 • 101 citations

Amphicrine cells, dysplasias, and neoplasias

1985 • 99 citations

Biogenic amines as regulators of the proliferative activity of normal and neoplastic intestinal epithelial cells (review).

1987 • 98 citations

Prostatic Carcinoma: Histological and Immunohistological Factors Affecting Prognosis

1990 • 96 citations

Serotonin and morphogenesis : I. Sites of serotonin uptake and -binding protein immunoreactivity in the midgestation mouse embryo

1988 • 89 citations

The prevalence and prognostic significance of argyrophil cells in colorectal carcinomas

1984 • 88 citations

Endocrine-paracrine cells of the prostate and prostatic urethra: An ultrastructural study

1984 • 87 citations

The endocrine cells of the digestive system: amines, peptides, and modes of action

1986 • 85 citations

Endocrine cells in the prostate gland, urothelium and brenner tumors

1982 • 83 citations

Effects of bombesin on growth of human small cell lung carcinoma in vivo

1989 • 83 citations

The endocrine component of prostatic carcinomas, mixed adenocarcinoma‐carcinoid tumours and non‐tumour prostate. Histochemical and ultrastructural identification of the endocrine cells

1981 • 83 citations

Zur Frage der Endokrinie der menschlichen vorsteherdrüse

1944 • 82 citations

Argentaffin and argyrophil cells in the prostate

1974 • 81 citations

Somatostatin and/or somatostatin-like immunoreactive endocrine-paracrine cells in the human prostate gland.

1984 • 77 citations

Immunoreactive gastrin-releasing peptide as a specific tumor marker in patients with small cell lung carcinoma.

1989 • 75 citations

Immunocytochemical localization of progesterone receptors in endocrine cells of the human pancreas.

1990 • 73 citations

Calcitoninlike immunoreactive and bombesinlike immunoreactive endocrine-paracrine cells of the human prostate.

1986 • 72 citations

On the possible existence of multiple endocrine, paracrine and neurocrine messengers in secretory cell systems.

1980 • 72 citations

Ectopic production of human chorionic gonadotropin (hCG) by neoplasms: The value of measurements of immunoreactive hCG in the urine as a screening procedure

1980 • 70 citations

Prostatic adenocarcinoma with carcinoidal features producing adrenocorticotropic syndrome. Immunohistochemical study and review of the literature

1984 • 68 citations

The Use of the Long-Acting Somatostatin Analog Octreotide in the Treatment of Gut Neuroendocrine Tumors*

1991 • 65 citations

Characterization by Immunofluorescence of an ACTH-like Substance in Nonpituitary Tumors from Patients with Hyperadrenocorticism1

1964 • 64 citations

Inhibition of rat prostate tumor growth by an octapeptide analog of somatostatin

1987 • 64 citations

Relationship of ectopic ACTH production to tumor differentiation: A morphologic and immunohistochemical study of prostatic carcinoma with cushing's syndrome

1981 • 64 citations

Small-cell carcinoma of prostate

1985 • 62 citations

Breast Carcinomas with Neuroendocrine Differentiation

1985 • 62 citations

Small cell carcinoma of prostate associated with myasthenic (eaton-lambert) syndrome

1989 • 60 citations

Carcinoid tumor of the prostate associated with adenocarcinoma

1979 • 60 citations

Effect of bombesin and caerulein on early stages of carcinogenesis induced by azaserine in the rat pancreas.

1987 • 59 citations

Primary prostatic carcinoid tumor with intracytoplasmic prostatic acid phosphatase and prostate-specific antigen

1984 • 57 citations

Investigation on serum neurone‐specific enolase in prostate cancer diagnosis and monitoring: Comparative study of a multiple tumor marker assay

1991 • 57 citations

Xenografted small cell undifferentiated cancer of prostate: Possible common origin with prostatic adenocarcinoma

1987 • 55 citations

Expression of the C-terminal peptide of human pro-bombesin in 361 lung endocrine tumours, a reliable marker and possible prognostic indicator for small cell carcinoma

1987 • 52 citations

Primary carcinoid of prostate

1979 • 52 citations

Small Cell Carcinoma of the Prostate Gland With Inappropriate Antidiuretic Hormone Secretion: Morphological, Immunohistochemical and Clinical Expressions

1986 • 51 citations

Proliferation of endocrine (APUD-type) cells during early N-diethylnitrosamine-induced lung carcinogenesis in hamsters

1975 • 49 citations

Partial characterization of a thyroid‐stimulating hormone‐like peptide in neuroendocrine cells of the human prostate gland

1989 • 48 citations

Gut and Pancreatic Amine Precursor Uptake and Decarboxylation Cells Are Not Neural Crest Derivatives

1983 • 47 citations

High concentration of immunoreactive calcitonin of prostatic origin in human semen

1980 • 45 citations

Inappropriate secretion of antidiuretic hormone by carcinoma of the prostate

1969 • 45 citations

Calcitonin, katacalcin, and calcitonin gene-related peptide in the human prostate. An immunocytochemical and immunoelectron microscopic study.

1989 • 45 citations

Carcinoma of the prostate with Cushing's syndrome. A case report with histochemical and chemical demonstration of immunoreactive corticotropin-releasing hormone in plasma and tumoral tissue.

1988 • 45 citations

The Neuroendocrine Prostate: Characterization and Quantitation of Calcitonin in the Human Gland

1989 • 43 citations

Small cell carcinoma of the prostate

1991 • 43 citations

Seminal concentrations of total and ionized calcium from men with normal and decreased motility

1990 • 42 citations

Age-related changes in the neuroendocrine (endocrine-paracrine) cell population and the serotonin content of the guinea pig prostate.

1987 • 42 citations

ADRENOCORTICAL HYPERPLASIA OCCURRING WITH METASTATIC CARCINOMA OF THE PROSTATE: REPORT OF A CASE EXHIBITING INCREASED URINARYALDOSTERONE AND GLUCOCORTICOID EXCRETION*

1959 • 42 citations

Immunocytochemical evaluation of human prostatic carcinomas for carcinoembryonic antigen, nonspecific cross-reacting antigen, beta-chorionic gonadotrophin, and prostate-specific antigen.

1984 • 41 citations

Receptors for prolactin, somatostatin, and luteinizing hormone-releasing hormone in experimental prostate cancer after treatment with analogs of luteinizing hormone-releasing hormone and somatostatin.

1988 • 41 citations

Human Pituitary Tumors Secrete Chromogranin-A*

1989 • 41 citations

Human Chorionic Gonadotropin Detected in Urinary Concentrates From Patients with Malignant Tumors of the Testis, Prostate, Bladder, Ureter and Kidney

1983 • 41 citations

Immunoreactivities for chromogranin A and B, and secretogranin II in the guinea pig entero-endocrine system: cellular distributions and intercellular heterogeneities

1991 • 41 citations

Clinical Use of a Monoclonal Antibody to Bombesin‐like Peptide in Patients with Lung Cancer^a,b

1988 • 38 citations

Immunoreactive Somatostatin in Male Reproductive System in Humans*

1989 • 38 citations

Argyrophilic prostatic carcinoma. Case report with literature review on prostatic carcinoid and “carcinoid-like” prostatic carcinoma

1985 • 38 citations

Neuroendocrine differentiation and prostatic carcinoma. The concept 'comes of age'.

1988 • 35 citations

Pure small-cell carcinoma of the prostate with fatal liver metastasis.

1986 • 35 citations

Morphological and immunohistochemical investigations of the utriculus prostaticus from the fetal period up to adulthood

1990 • 34 citations

Ectopic adrenocorticotropin syndrome with prostatic carcinoma

1973 • 34 citations

Prostatic adenocarcinoma evolving into carcinoid: selective effect of hormonal treatment?

1986 • 34 citations

Ectopic ACTH production in disseminated prostatic adenocarcinoma

1975 • 33 citations

Paraneoplastic Syndromes Associated with Prostatic Carcinoma

1987 • 32 citations

Hypercalcemia in Prostatic Carcinoma

1983 • 31 citations

Ectopic hormone production by a prostatic small cell carcinoma xenograft line

1988 • 31 citations

Carcinoid Tumour of the Prostate Associated with Inappropriate ACTH Secretion

1985 • 30 citations

Carcinoma of the prostate with Cushing's syndrome

1988 • 30 citations

Placental proteins and their subunits as tumor markers in prostatic carcinoma

1977 • 30 citations

Diagnosis of Carcinoid-like Metastatic Prostatic Carcinoma by an Immunoperoxidase Method

1981 • 30 citations

Diffuse carcinoid of prostate

1981 • 29 citations

Calcitonin immunoreactive cells in prostate gland and cloacal derived tissues

1986 • 29 citations

How Sensitive and Specific Is Measurement of Plasma Chromogranin A for the Diagnosis of Neuroendocrine Neoplasia?a

1987 • 28 citations

Small-cell carcinoma of prostate

1989 • 27 citations

Calcium fractions in seminal plasma and functional properties of human spermatozoa

1982 • 27 citations

Antibodies to neuron-specific enolase for the delineation of the entire diffuse neuroendocrine system in health and disease.

1984 • 26 citations

Production of beta-human chorionic gonadotropin by prostatic adenocarcinoma and transitional cell carcinoma of the upper urinary tract.

1987 • 25 citations

Calcitonin-Secreting Carcinomas of the Prostate

1986 • 24 citations

Prostatic Carcinoma with Endocrine Features: A Report of a Neoplasm Containing Multiple Immunoreactive Hormonal Substances

1987 • 24 citations

Argyrophilic, 'carcinoid-like' prostatic carcinoma. An immunocytochemical study.

1986 • 23 citations

Glycoprotein hormone alpha-chain-immunoreactive endocrine cells in prostate and cloacal-derived tissues.

1987 • 23 citations

Site-specific growth of the prostate xenograft line UCRU-PR-2

1989 • 22 citations

Production of calcitonin gene related peptide, calcitonin and PTH‐related protein by a prostatic adenocarcinoma

1991 • 21 citations

The Enterochromaffin Cells in the Mouse Gastrointestinal Tract after Streptozotocin Treatment

1990 • 21 citations

ALPHA1-Antitrypsin phenotypes in homosexual men

1989 • 20 citations

A.P.U.D. type endocrine tumour of the prostate. Incidence and prognosis in association with adenocarcinoma.

1987 • 20 citations

Symptomatic hypokalemic alkalosis in hyperadrenocorticism secondary to carcinoma of the prostate

1968 • 18 citations

Prostatic carcinoma producing syndrome of inappropriate secretion of antidiuretic hormone

1975 • 18 citations

Prostatic Adenocarcinoma with Ectopic ACTH Production

1978 • 18 citations

Determination of serotonin and 5‐hydroxyindoleacetic acid in guinea pig and human prostate using HPLC

1987 • 18 citations

Hormonal therapy of prostatic carcinoma Is there a rationale for delayed treatment?

1986 • 18 citations

HYPERADRENOCORTICISM ASSOCIATED WITH "REACTIVATED" PROSTATIC CARCINOMA.

1965 • 15 citations

Small cell carcinoma of prostate

1989 • 15 citations

Hypercalcemia in carcinoma of prostate Its cure by

1985 • 15 citations

In vivo enhancement of antitumor immunity by interleukin 2-rich lymphokines.

1986 • 14 citations

Immunoextracted calcitonin from human seminal plasma constitutes different forms

1986 • 11 citations

Gut endocrine and neural peptides

1990 • 11 citations

Isolation of a human seminal plasma peptide with bombesin-like activity

1989 • 11 citations

Bombesin-like immunoreactivity in human seminal fluid

1987 • 10 citations

Endocrine-Paracrine Cells in Prostatic Carcinoma and Clinical Course of the Disease

1985 • 10 citations

Somatostatin inhibits VIP‐ and isoproterenol‐stimulated cyclic AMP accumulation in rat prostatic epithelial cells

1987 • 9 citations

[Extrapulmonary small-cell carcinoma - a rarity with important therapeutic consequences].

1984 • 9 citations

Calcitonin Concentrations in Lung Cancer and Non-Malignant Pulmonary Diseases

1987 • 8 citations

[Carcinoid tumor of the prostate. A new anatomoclinical case and review of the literature].

1985 • 7 citations

Amine dependence of proliferative activity in two transplantable lines of mouse colonic carcinoma

1987 • 5 citations

[A case of small cell carcinoma of the prostate].

1988 • 4 citations

[Endocrine differentiated prostate cancer. Histology and immunohistochemistry].

1990 • 4 citations

[Composite carcinoma of the prostate combining a small cell carcinoma and an adenocarcinoma. Apropos of a case].

1989 • 3 citations

PRIMARY CARCINOID TUMOR OF THE PROSTATE

1980 • 3 citations

[Carcinoid tumor of the prostate].

1982 • 3 citations

Parathyroid hormone: another pregnancy protein present in human seminal plasma and amniotic fluid

2009 • 3 citations

[Unique papillary cystadenocarcinoma of the prostate with endocrine cells].

1985 • 1 citations