Design and synthesis of novel, pseudo C2 symmetric inhibitors of HIV protease

Readily accessible 12-I-5 oxidant for the conversion of primary and secondary alcohols to aldehydes and ketones

1983 • 3,015 citations

STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE

1993 • 822 citations

Design, Activity, and 2.8 Å Crystal Structure of a C ₂ Symmetric Inhibitor Complexed to HIV-1 Protease

1990 • 524 citations

Advances in pharmacology

1962 • 412 citations

HIV protease: a novel chemotherapeutic target for AIDS

1991 • 411 citations

The HIV-1 Protease as a Therapeutic Target for AIDS

1992 • 343 citations

New Approaches to the Use of Amino Acids as Chiral Building Blocks in Organic Synthesis [New Synthetic Methods (85)]

1991 • 322 citations

Removal of benzyl-type protecting groups from peptides by catalytic transfer hydrogenation with formic acid

1979 • 216 citations

Structure-based, C2 symmetric inhibitors of HIV protease

1990 • 213 citations

Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease

1991 • 133 citations

Inhibitors of HIV-1 Protease

1992 • 118 citations

X-ray crystal structure of the HIV protease complex with L-700,417, an inhibitor with pseudo C2 symmetry

1991 • 118 citations

Diastereoselective catalytic asymmetric nitroaldol reaction utilizing rare earth-Li-(R)-BINOL complex. A highly efficient synthesis of norstatine

1994 • 111 citations

Recent advances in the design of HIV proteinase inhibitors

1992 • 97 citations

The complexities of AIDS : an assessment of the HIV protease as a therapeutic target

1991 • 88 citations

Desoxy‐nitrozucker. 3. Mitteilung. Synthese von Ketosen durch Kettenverlängerung von 1‐Desoxy‐1‐nitro‐aldosen. Nucleophile Additionen und Solvolyse von Nitroaethern

1982 • 80 citations

Silica gel-assisted reduction of nitrostyrenes to 2-aryl-1-nitroalkanes with sodium borohydride

1983 • 76 citations

Chapter 15. HIV Protease Inhibitors

1991 • 74 citations

Chapter 14. HIV Protease Inhibitors

1994 • 69 citations

Amino Diol HIV Protease Inhibitors. 1. Design, Synthesis, and Preliminary SAR

1994 • 67 citations

Generation of functional diversity via nitroaldol condensations of α-aminoacid aldehydes — A new and stereocontrolled route to acyclic 1,3-diamino-2-alcohols

1996 • 55 citations

Design of orally bioavailable, symmetry-based inhibitors of HIV protease

1994 • 55 citations

Synthesis of C2-symmetric and pseudosymmetric HIV-1 protease inhibitors from D-arabitol

1991 • 40 citations

A simple synthetic route to statine and statine analogues

1989 • 39 citations

Design and Reactivity of Organic Functional Groups — 2-Pyridylsulfonates as Nucleofugal Esters: Remarkably Mild Transformations into HAlides and Olefins

1989 • 31 citations

The use of HIV-1 protease structure in inhibitor design

1992 • 30 citations

A New Synthetic Method for the Preparation of Ketones by Denitration of α-Nitro Ketones

1987 • 27 citations

HIV protease: Structure-based design

1993 • 25 citations

HIV‐1 Protease Inhibitors: Development, Status, and Potential Role in the Treatment of AIDS

1993 • 22 citations

1,3-dipolar cycloaddition approach towards the stereoselective preparation of Aza-cephalotaxine skeleton

1995 • 22 citations

A new, highly efficient synthesis of conjugated nitrocycloalkenes

1994 • 20 citations

1,3-dipolar cycloaddition approach towards the stereoselective preparation of aza-cephalotaxine skeleton

1994 • 18 citations

Time-Resolved Ligand Exchange Reactions: Kinetic Models for Competitive Inhibitors with Recombinant Human Renin

1995 • 13 citations

Synthesis of novel cyclic hydroxamic acids

1994 • 13 citations

Novel, extended transition state mimic in HIV-1 protease inhibitors with peripheral C-2-symmetry

1994 • 9 citations

Structure-based design of achiral anthranilamides as P2/P2′ surrogates for symmetry-based HIV protease inhibitors: design, synthesis, X-ray structure, enzyme inhibition and antiviral activity

1995 • 6 citations