Serotonin as a developmental signal

PATTERN OF MALFORMATION IN OFFSPRING OF CHRONIC ALCOHOLIC MOTHERS

1973 • 2,156 citations

The Fetal Alcohol Syndrome

1978 • 1,371 citations

Chromosome abnormalities found among 34910 newborn children: results from a 13-year incidence study in �rhus, Denmark

1991 • 1,093 citations

Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system

1978 • 809 citations

Neurotransmitters as growth regulatory signals: role of receptors and second messengers

1993 • 806 citations

Brain malformations related to prenatal exposure to ethanol

1978 • 669 citations

Serotonin Selectively Inhibits Growth Cone Motility and Synaptogenesis of Specific Identified Neurons

1984 • 544 citations

Serotonin and substance P coexist in neurons of the rat's central nervous system

1978 • 483 citations

Incidence of fetal alcohol syndrome and economic impact of FAS-related anomalies

1987 • 477 citations

Serotonin as a Differentiation Signal in Early Neurogenesis

1978 • 454 citations

Ontogeny of the Serotonergic System in the Rat: Serotonin as a Developmental Signal^a

1990 • 403 citations

Development of the serotonergic system in the rat embryo: An immunocytochemical study

1983 • 398 citations

Purification and characterization of a neurite extension factor from bovine brain.

1985 • 378 citations

X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism.

1993 • 363 citations

Stimulation of astroglial 5-HT1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology

1990 • 317 citations

Neurobehavioral teratology

1984 • 306 citations

Attention Deficits in Children Exposed to Alcohol Prenatally

1990 • 280 citations

The patterns of neurotransmitter and neuropeptide co-occurrence among striatal projection neurons: conclusions based on recent findings

1990 • 276 citations

Prenatal alcohol exposure and long-term developmental consequences

1993 • 275 citations

Development of the central nervous system : effects of alcohol and opiates

1992 • 252 citations

Thermal control of mother-young contact in rats

1978 • 249 citations

In vivo and in vitro development of serotonergic neurons

1982 • 241 citations

Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug

1986 • 231 citations

S-100B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor

1990 • 230 citations

Role of serotonin and other neurotransmitter receptors in brain development: basis for developmental pharmacology.

1991 • 230 citations

Teratogenic Effects of Alcohol on Infant Development

1993 • 217 citations

Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor.

1991 • 216 citations

Hormonal and humoral influences on brain development

1983 • 213 citations

Sprouting of serotoninergic afferents into striatum after dopamine‐depleting lesions in infant rats: A retrograde transport and immunocytochemical study

1986 • 188 citations

The effects of serotonin on the morpho-functional development of rat cerebral neocortex in tissue culture

1986 • 187 citations

Neuropsychological Deficits in Fetal Alcohol Syndrome and Fetal Alcohol Effects

1990 • 186 citations

Dopamine and serotonin inhibition of neurite elongation of different identified neurons

1988 • 174 citations

The regulation of neurite outgrowth, growth cone motility, and electrical synaptogenesis by serotonin

1987 • 170 citations

Autoregulation of fetal serotonergic neuronal development: Role of high affinity serotonin receptors

1986 • 167 citations

Neurogenesis in the rat neostriatum

1984 • 161 citations

The topographical distribution of serotoninergic terminals in the neostriatum of the rat and the caudate nucleus of the cat

1977 • 148 citations

Postnatal changes in serotonin1 receptors following prenatal alterations in serotonin levels: further evidence for functional fetal serotonin1 receptors

1987 • 145 citations

Stimulation of astroglial serotonin receptors produces culture media which regulates growth of serotonergic neurons

1989 • 142 citations

Children of Alcoholic Mothers: Developmental, Perceptual and Behavioural Characteristics as Compared to Matched Controls

1985 • 137 citations

Transient expression of 5‐HT_1A receptor binding sites in some areas of the rat CNS during postnatal development

1987 • 134 citations

Neurobehavioral Dose‐Response Effects of Prenatal Alcohol Exposure in Humans from Infancy to Adulthood^a

1989 • 132 citations

Synaptogenesis in the corpus striatum of infant rat

1973 • 129 citations

Effects of p-chlorophenylalanine on time of neuronal origin during embryo-genesis in the rat

1976 • 125 citations

Sprouting of striatal serotonin nerve terminals following selective lesions of nigro-striatal dopamine neurons in neonatal rat

1987 • 122 citations

Neonatal and Adult 6-Hydroxydopamine-Induced Lesions Differentially Alter Tachykinin and Enkephalin Gene Expression

1987 • 122 citations

S‐100β and insulin‐like growth factor‐II differentially regulate growth of developing serotonin and dopamine neurons in vitro

1992 • 122 citations

Development of psychopathology of children with the fetal alcohol syndrome.

1982 • 118 citations

Dopamine, Serotonin, and Acid Metabolites in Brain Regions from the Developing Offspring of Ethanol‐Treated Rats

1985 • 116 citations

Altered branching of serotonin-containing neurons in Drosophila mutants unable to synthesize serotonin and dopamine

1989 • 115 citations

Fetal human brain exhibits a prenatal peak in the density of serotonin 5-HT1A receptors

1991 • 111 citations

Monoamine oxidase deficiency in males with an X chromosome deletion

1989 • 110 citations

Effects of in Utero Ethanol Exposure on the Developing Serotonergic System

1991 • 107 citations

Serotonergic innervation of the rat caudate following a neonatal 6-hydroxydopamine lesion: An anatomical, biochemical and pharmacological study

1989 • 103 citations

The infant rat separation paradigm: a novel test for novel anxiolytics

1991 • 103 citations

5-HT1C receptor-mediated stimulation of inositol phosphate production in pig choroid plexus

1989 • 102 citations

Development and Psychopathology of Children with the Fetal Alcohol Syndrome

1982 • 101 citations

Dose-related effects of prenatal 5-methoxytryptamine (5-MT) on development of serotonin terminal density and behavior

1991 • 87 citations

Children of alcoholic mothers.

1987 • 87 citations

Astroglial 5-HT1a receptors and S-100 beta in development and plasticity.

1994 • 85 citations

Effects of buspirone and its metabolite, 1-(2-pyrimidinyl)piperazine, on brain monoamines and their metabolites in rats.

1989 • 84 citations

DEVELOPMENTAL CHANGES IN THE BRAIN LEVELS OF NEUROTRANSMITTERS AS INFLUENCED BY MATERNAL ETHANOL CONSUMPTION IN THE RAT¹

1977 • 83 citations

Causes of Blindness in Children: Twenty-Five Years' Experience of Danish Institutes for the Blind

2017 • 83 citations

CAUSES OF BLINDNESS IN CHILDREN

1927 • 81 citations

Serotonin promotes region‐specific glial influences on cultured serotonin and dopamine neurons

1992 • 79 citations

Role of High Affinity Serotonin Receptors in Neuronal Growth^a

1990 • 78 citations

Increased aggressiveness and lower brain serotonin levels in offspring of mice given alcohol during gestation.

1977 • 76 citations

Submicroscopic interstitial deletion of the X chromosome explains a complex genetic syndrome dominated by Norrie disease

1986 • 75 citations

Serotonin initiates and autoamplifies its own synthesis during mouse central nervous system development.

1986 • 74 citations

Alcohol and neurobiology : brain development and hormone regulation

1992 • 72 citations

Norrie disease resulting from a gene deletion: clinical features and DNA studies.

1988 • 69 citations

PSYCHOLOGIC HANDICAPS IN CHILDREN WITH THE FETAL ALCOHOL SYNDROME*

1976 • 68 citations

Synaptic properties of serotonergic growth cones in developing rat brain

1994 • 65 citations

Roles for Serotonin in Neurogenesis1

2015 • 63 citations

Prenatal Expression of 5-HT1C and 5-HT2 Receptors in the Rat Central Nervous System

1993 • 63 citations

Ontogeny of 5-hydroxytryptamine2 receptor immunoreactivity in the developing rat brain

1993 • 61 citations

Cellular localization of serotonin 1A, 1B and uptake sites in cingulate cortex of the rat.

1990 • 56 citations

Marked Amine and Amine Metabolite Changes in Norrie Disease Patients with an X‐Chromosomal Deletion Affecting Monoamine Oxidase

1990 • 55 citations

Serotonin regulation of tachykinin biosynthesis in the rat neostriatum

1991 • 52 citations

Maternal ethanol consumption and synaptic membrane glycoproteins in offspring

1982 • 51 citations

Tissue-dependent alpha adrenoceptor activity of buspirone and related compounds.

1987 • 47 citations

Effects of in utero ethanol exposure on serotonin uptake in cortical regions

1988 • 45 citations

In Vivo Neurochemical Evaluation of Striatal Serotonergic Hyperinnervation in Rats Depleted of Dopamine at Infancy

1992 • 44 citations

Neuro-glial neurotrophic interaction in the S-100β retarded mutant mouse (Polydactyly Nagoya). I. Immunocytochemical and neurochemical studies

1994 • 44 citations

Platelet MAO and measures of attention and impulsivity in boys with attention deficit disorder and hyperactivity

1986 • 43 citations

Exploring the Connections between Platelet Monoamine Oxidase Activity and Behavior: Relationships with Performance in Neuropsychological Tasks

1990 • 42 citations

Treatment of Pregnant Alcohol‐Consuming Rats with Buspirone: Effects on Serotonin and 5‐Hydroxyindoleacetic Acid Content in Offspring

1993 • 41 citations

Effects of Ethanol on Cultured Fetal Astroglia

1993 • 39 citations

Low Platelet Gamma‐Aminobutyrate Aminotransferase and Monoamine Oxidase Activities in Chronic Alcoholic Patients

1992 • 39 citations

Clinical, Psychopathological and Developmental Aspects in Children with the Fetal Alcohol Syndrome: A Four‐Year Followup Study

1984 • 36 citations

Chronic maternal ethanol consumption results in decreased serotonergic 5-HT1 sites in cerebral cortical regions from offspring

1988 • 35 citations

Serotonin depletors, 5,7-dihydroxytryptamine and p-chlorophenylalanine, cause sprouting in the CNS of the adult snail

1993 • 33 citations

Effect of Prenatal Alcohol Exposure on Amine and Peptide Neurotransmitter Systems

2015 • 32 citations

Exploring the Connections between Platelet Monoamine Oxidase Activity and Behavior

1992 • 32 citations

Mechanisms of Alcohol Damage in Utero

1985 • 29 citations

Effects of prenatal 5-methoxytryptamine and parachlorophenylalanine on serotonergic uptake and behavior in the neonatal rat

1988 • 27 citations

Neurochemical effects of buspirone, a novel psychotropic drug, on the central cholinergic system

1982 • 26 citations

Glial heterogeneity and developing neurotransmitter systems.

1994 • 24 citations

Serotonin regulation of neostriatal tachykinins following neonatal 6-hydroxydopamine lesions

1991 • 24 citations

Effect of alcohol given at different periods of gestation on brain serotonin in offspring.

1978 • 24 citations

Pharmacological characterization of regulation of phosphoinositide metabolism by recombinant 5-HT2 receptors of the rat

1992 • 22 citations

Effects of maternal ethanol ingestion on cerebral neurotransmitters and cyclic-AMP in the rat offspring

1982 • 21 citations

Tryptophan hydroxylase inhibition increases preprotachykinin mRNA in developing and adult medullary raphe nuclei

1990 • 19 citations

Prenatal interactions between ethanol and the industrial solvent 2-ethoxyethanol in rats: neurochemical effects in the offspring.

1982 • 15 citations

Effect of serotonin on growth and differentiation of hippocampal cells in culture

1980 • 12 citations

A comparison of substance P peptide and preprotachykinin mRNA levels during development of rat medullary raphe and neostriatum

1991 • 11 citations

The effect of long-term ethanol maternal ingestion and withdrawal on brain regional monoamine and amino acid precursors in 15-day-old rats

1984 • 11 citations

Effects of Ethanol on Cultured Fetal Serotonergic Neurons

1993 • 9 citations

Maternal Ethanol Consumption: Effects on G Proteins and Second Messengers in Brain Regions of Offspring

1994 • 9 citations

The prevention of Down's syndrome in the south western region of England 1975-1985.

1990 • 3 citations