A five-conductance model of the action potential in the rat sympathetic neurone

An Algorithm for Least-Squares Estimation of Nonlinear Parameters

1963 • 29,357 citations

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

The effect of sodium ions on the electrical activity of the giant axon of the squid

1949 • 3,479 citations

POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES

1943 • 2,733 citations

Three types of neuronal calcium channel with different calcium agonist sensitivity

1985 • 2,212 citations

Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone

1980 • 1,423 citations

Diversity and ubiquity of K channels

1988 • 1,342 citations

Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones.

1987 • 1,290 citations

Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia.

1966 • 1,208 citations

Calcium Channel

1981 • 1,184 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Voltage clamp studies of a transient outward membrane current in gastropod neural somata

1971 • 1,122 citations

Classes of Calcium Channels in Vertebrate Cells

1989 • 1,082 citations

Sodium and calcium channels in bovine chromaffin cells

1982 • 983 citations

Dominant Role of N-Type Ca ²⁺ Channels in Evoked Release of Norepinephrine from Sympathetic Neurons

1988 • 859 citations

Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma

1971 • 752 citations

The after‐effects of impulses in the giant nerve fibres of Loligo

1956 • 748 citations

Varieties of Calcium-Activated Potassium Channels

1989 • 731 citations

The function of calcium in the potassium permeability of human erythrocytes

1958 • 652 citations

Ca-dependent K channels with large unitary conductance in chromaffin cell membranes

1981 • 647 citations

Potassium activation in Helix aspersa neurones under voltage clamp: a component mediated by calcium influx.

1975 • 626 citations

Single‐channel recordings of three types of calcium channels in chick sensory neurones.

1987 • 563 citations

Calcium-dependent current generating the afterhyperpolarization of hippocampal neurons

1986 • 560 citations

Properties of two calcium‐activated hyperpolarizations in rat hippocampal neurones.

1987 • 554 citations

Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle

1986 • 553 citations

Ionic currents in the somatic membrane of rat dorsal root ganglion neurons—I. Sodium currents

1981 • 520 citations

Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila

1988 • 495 citations

GLIA IN THE LEECH CENTRAL NERVOUS SYSTEM: PHYSIOLOGICAL PROPERTIES AND NEURON-GLIA RELATIONSHIP

1964 • 482 citations

Single Na+ channel currents observed in cultured rat muscle cells

1980 • 452 citations

Pharmacological inhibition of the M‐current

1982 • 434 citations

Two Fast Transient Current Components during Voltage Clamp on Snail Neurons

1971 • 428 citations

Kinetics and selectivity of a low‐voltage‐activated calcium current in chick and rat sensory neurones.

1987 • 420 citations

Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cells.

1985 • 415 citations

Two types of calcium channels in the somatic membrane of new‐born rat dorsal root ganglion neurones.

1985 • 412 citations

Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel

1987 • 412 citations

Calcium-Mediated Reduction of Ionic Currents: A Biophysical Memory Trace

1984 • 399 citations

Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes

1988 • 396 citations

Presynaptic calcium currents in squid giant synapse

1981 • 366 citations

Calcium-activated potassium channels

1987 • 342 citations

The A-current: how ubiquitous a feature of excitable cells is it?

1985 • 328 citations

A low voltage-activated calcium conductance in embryonic chick sensory neurons

1984 • 302 citations

Biophysics and physiology of excitable membranes

1971 • 290 citations

A Family of Putative Potassium Channel Genes in Drosophila

1989 • 281 citations

Slow inactivation of the sodium conductance in squid giant axons. Pronase resistance.

1978 • 263 citations

Membrane changes of Onchidium nerve cell in potassium‐rich media

1961 • 234 citations

A fast transient outward current in the rat sympathetic neurone studied under voltage‐clamp conditions.

1985 • 227 citations

A transient potassium conductance regulates the excitability of cultured hippocampal and spinal neurons

1984 • 224 citations

Changes in extracellular potassium concentration produced by neuronal activity in the central nervous system of the leech

1969 • 219 citations

Depolarization elicits two distinct calcium currents in vertebrate sensory neurones

1985 • 216 citations

Intracellular calcium regulation

1991 • 210 citations

Physiology of autonomic ganglia

1973 • 180 citations

Characteristics of phasic and tonic sympathetic ganglion cells of the guinea‐pig.

1986 • 174 citations

Action potential repolarization may involve a transient, Ca2+ -sensitive outward current in a vertebrate neurone

1982 • 165 citations

Simulation of intrinsic bursting in CA3 hippocampal neurons

1982 • 163 citations

Calcium‐dependent potentials in the mammalian sympathetic neurone.

1979 • 161 citations

The Effects of External Potassium and Long Duration Voltage Conditioning on the Amplitude of Sodium Currents in the Giant Axon of the Squid, Loligo pealei

1969 • 158 citations

Single-Channel and Genetic Analyses Reveal Two Distinct A-Type Potassium Channels in Drosophila

1987 • 156 citations

Action Potential of the Motorneuron

1973 • 153 citations

Control of calcium current in rat sympathetic neurons by norepinephrine

1982 • 151 citations

Single low‐voltage‐activated calcium channels in chick and rat sensory neurones.

1987 • 144 citations

Outward currents in voltage‐clamped rat sympathetic neurones.

1984 • 140 citations

Transient voltage and calcium-dependent outward currents in hippocampal CA3 pyramidal neurons

1985 • 135 citations

The slow calcium‐dependent potassium current in a myenteric neurone of the guinea‐pig ileum.

1985 • 134 citations

Potassium ion accumulation in a periaxonal space and its effect on the measurement of membrane potassium ion conductance

1973 • 133 citations

Patch-clamp studies of isolated mouse olfactory receptor neurons.

1987 • 131 citations

Blockade of Ca‐activated K conductance by apamin in rat sympathetic neurones

1986 • 124 citations

The effect of temperature on the asymmetrical charge movement in squid giant axons.

1979 • 118 citations

Slow changes in membrane permeability and long‐lasting action potentials in axons perfused with fluoride solutions

1970 • 115 citations

On numerical integration of the Hodgkin and Huxley equations for a membrane action potential

1974 • 112 citations

Large and small conductance calcium-activated potassium channels in the GH3 anterior pituitary cell line

1987 • 111 citations

Identification of delayed potassium and calcium currents in the rat sympathetic neurone under voltage clamp.

1985 • 109 citations

The formation of synapses in mammalian sympathetic ganglia reinnervated with preganglionic or somatic nerves

1974 • 105 citations

Pharmacological and physiological properties of the after‐hyperpolarization current of bullfrog ganglion neurones.

1987 • 96 citations

Single Na channels in mouse neuroblastoma cell membrane

1983 • 94 citations

INTRACELLULAR OBSERVATIONS ON THE EFFECTS OF MUSCARINIC AGONISTS ON RAT SYMPATHETIC NEURONES

1980 • 93 citations

Single calcium‐activated potassium channels recorded from cultured rat sympathetic neurones.

1987 • 91 citations

The spatial distribution of ionic conductances in normal and axotomized motorneurons

1977 • 88 citations

The properties of calcium‐activated potassium ion channels in guinea‐pig isolated hepatocytes.

1989 • 87 citations

Development of excitable membrane properties in mammalian sympathetic neurons

1989 • 80 citations

Sodium and calcium currents of acutely isolated adult rat superior cervical ganglion neurons

1988 • 75 citations

Solutions of the Hodgkin-Huxley equations modified for potassium accumulation in a periaxonal space

1975 • 74 citations

Potassium currents evoked by brief depolarizations in bull‐frog sympathetic ganglion cells.

1987 • 73 citations

Two transient outward currents in histamine neurones of the rat hypothalamus in vitro.

1990 • 65 citations

Single transient K channels in mammalian sensory neurons

1986 • 63 citations

Membrane currents in adult rat superior cervical ganglia in dissociated tissue culture

1987 • 61 citations

Ionic currents in the somatic membrane of rat dorsal root ganglion neurons —III. Potassium currents

1981 • 61 citations

The effect of a transient outward current (IA) on synaptic potentials in sympathetic ganglion cells of the guinea‐pig.

1986 • 60 citations

G proteins and signal transduction.

1990 • 58 citations

ELECTROLYTE DISTRIBUTION IN RABBIT SUPERIOR CERVICAL GANGLION¹

1969 • 55 citations

Changes of intracellular sodium and potassium ion concentrations in isolated rat superior cervical ganglia induced by depolarizing agents

1974 • 54 citations

Three kinetically distinct potassium channels in mouse neuroblastoma cells.

1988 • 52 citations

Inactivation of A currents and A channels on rat nodose neurons in culture.

1989 • 50 citations

Isolation and kinetic analysis of inward currents in neuroblastoma cells

1984 • 50 citations

Modulation of the Excitatory Synaptic Response by Fast Transient K+ Current in Snail Neurones

1973 • 49 citations

Single‐channel analysis of fast transient potassium currents from rat nodose neurones.

1985 • 49 citations

Membrane currents of cultured rat sympathetic neurons under voltage clamp

1983 • 49 citations

Temperature dependence of the ionic current kinetics of Myxicola giant axons

1973 • 48 citations

Intracellular electrolyte concentrations in rat sympathetic neurones measured with an electron microprobe

1984 • 44 citations

Simultaneous changes in the equilibrium potential and potassium conductance in voltage clamped Ranvier node in the frog.

1981 • 44 citations

The interactions between potassium and sodium currents in generating action potentials in the rat sympathetic neurone.

1988 • 39 citations

A quantitative description of the sodium current in the rat sympathetic neurone.

1986 • 38 citations

Modulation of M current in frog sympathetic ganglion cells.

1990 • 37 citations

Effect of temperature and calcium ions on rate constants of myelinated nerve

1971 • 35 citations

Single voltage-dependent potassium channels in cultured rat hippocampal neurons

1986 • 35 citations

Calcium and voltage dependence of single Ca2+-activated K+ channels from cultured hippocampal neurons of rat

1988 • 34 citations

A transient outward current in rat sympathetic neurones

1982 • 32 citations

Kinetics of activation of the sodium conductance in the squid giant axon.

1983 • 31 citations

The calcium‐dependent potassium conductance in rat sympathetic neurones.

1990 • 27 citations

The periaxonal space of crayfish giant axons.

1983 • 27 citations

K+ accumulation in the space between giant axon and Schwann cell in the squid Alloteuthis. Effects of changes in osmolarity

1988 • 26 citations

Intracellular free sodium and potassium, post-carbachol hyperpolarization, and extracellular potassium-undershoot in rat sympathetic neurones

1983 • 26 citations

Potassium channels in mouse neonate dorsal root ganglion cells: a patch-clamp study

1987 • 26 citations

Digital Filters

1974 • 26 citations

Calcium currents in the normal adult rat sympathetic neurone.

1989 • 21 citations

The Ca2+-sensitive K+-currents underlying the slow afterhyperpolarization of bullfrog sympathetic neurones

1987 • 18 citations

The rest-dependent depression of action potential duration in rabbit myocardium and the possible role of the transient outward current. A pharmacological analysis.

1982 • 18 citations

Modulation of synatpic output by the transient outward potassium current in Aplysia

1981 • 18 citations

Transient potassium currents in avian sensory neurons

1990 • 11 citations

Kinetic analysis of incomplete current tracings according to the Hodgkin-Huxley model

1988 • 8 citations

Computers in Medicine Series

1974 • 7 citations

Kinetics of activation of the potassium conductance in the squid giant axon

1988 • 7 citations