The role of the complement system in shock and tissue injury induced by tumour necrosis factor and endotoxin.

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.

1988 • 745 citations

Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.

1988 • 603 citations

Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor.

1988 • 300 citations

Experimental model of ischemic bowel necrosis. The role of platelet-activating factor and endotoxin.

1983 • 247 citations

Platelet‐activating factor: an endogenous mediator for bowel necrosis in endotoxemia

1987 • 154 citations

Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis.

1986 • 95 citations

A Single Gene Controlling Hemolytic Complement and a Serum Antigen in the Mouse

1964 • 78 citations

Tumor necrosis factor/cachectin. Induction of hemorrhagic necrosis in normal tissue requires the fifth component of complement (C5).

1988 • 49 citations

Protective Function of C6 in Rabbits Treated with Bacterial Endotoxin

1971 • 36 citations

The Requirement for Serum Complement in the Detoxification of Bacterial Endotoxin

1972 • 35 citations

Control of C3 levels in mice during ontogeny by a gene in the central region of the H–2 complex

1976 • 17 citations