Role of Tyrosinase as the Determinant of Pigmentation in Cultured Human Melanocytes

Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin.

1982 • 552 citations

Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus.

1987 • 448 citations

SUBCELLULAR LOCALIZATION OF MELANIN BIOSYNTHESIS

1963 • 390 citations

Some Aspects Of Melanin Biology: 1950–1975

1976 • 257 citations

Immunochemical Evidence for Increased Titers of Liver Tryptophan Pyrrolase during Substrate and Hormonal Enzyme Induction

1962 • 211 citations

Induction of pigmentation in mouse fibroblasts by expression of human tyrosinase cDNA.

1989 • 186 citations

Tyrosine hydroxylation catalyzed by mammalian tyrosinase: An improved method of assay

1964 • 182 citations

Alteration of Racial Differences in Melanosome Distribution in Human Epidermis after Exposure to Ultraviolet Light

1972 • 162 citations

Melanocyte-stimulating hormone promotes activation of pre-existing tyrosinase molecules in Cloudman S91 melanoma cells

1975 • 157 citations

Changes in melanogenesis during the dedifferentiation of chick retinal pigment cells in cell culture

1963 • 142 citations

Mammalian tyrosinase: biosynthesis, processing, and modulation by melanocyte-stimulating hormone.

1988 • 135 citations

Alpha-melanocyte-stimulating hormone regulation of tyrosinase in Cloudman S-91 mouse melanoma cell cultures.

1987 • 123 citations

The Relationship Between Tyrosinase Activity and Skin Color in Human Foreskins

1990 • 123 citations

Pigment content of cultured human melanocytes does not correlate with tyrosinase message level

1991 • 113 citations

A frequent tyrosinase gene mutation in classic, tyrosinase-negative (type IA) oculocutaneous albinism.

1990 • 75 citations

Regulation of tyrosinase mRNA levels in mouse melanoma cell clones by melanocyte-stimulating hormone and cyclic AMP

1989 • 61 citations

Regulation of mammalian melanogenesis by tyrosinase inhibition

1989 • 44 citations

Purification of human skin tyrosinase and its protein inhibitor: Properties of the enzyme and the mechanism of inhibition by protein

1982 • 44 citations

Tyrosinase activity in human skin. Influence of race and age in newborns.

1975 • 40 citations

Activation of the Melanocyte System by Ultraviolet Radiation and Cell Transformation^a

1985 • 35 citations

Down-regulation of tyrosinase mRNA levels in melanoma cells by tumor promoters and by insulin

1990 • 33 citations

The Control of Color in Mammals

1969 • 28 citations

Comparison of tyrosinase levels in amelanotic and melanotic melanoma cell cultures by a competitive enzyme‐linked immunoadsorbent assay and by immunotitration analysis

1988 • 24 citations

Activation of tyrosinase in mouse melanoma cell cultures

1987 • 10 citations

Regulation of the cytosolic and melanosome-bound tyrosinase activities in harding-passey mouse melanoma

1985 • 7 citations