Induction of differentiation and c‐jun expression in human leukemic cells by okadaic acid, an inhibitor of protein phosphatases

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Superoxide Dismutase

1969 • 12,578 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

[36] Eukaryotic gene transcription with purified components

1983 • 992 citations

Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

1988 • 940 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

1988 • 829 citations

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

1981 • 742 citations

Human Leukemic Models of Myelomonocytic Development: A Review of the HL-60 and U937 Cell Lines

1985 • 649 citations

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.

1988 • 595 citations

Induction of Differentiation in Human Promyelocytic Leukemia Cells by Tumor Promoters

1979 • 594 citations

Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia

1984 • 567 citations

Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain

1988 • 455 citations

Regulation of Ca2+ -dependent K+ -channel activity in tracheal myocytes by phosphorylation

1989 • 401 citations

Induction of c-fos during myelomonocytic differentiation and macrophage proliferation

1985 • 340 citations

Competitive inhibition by diacylglycerol of specific phorbol ester binding.

1984 • 306 citations

Expression of the c-fms proto-oncogene during human monocytic differentiation

1985 • 288 citations

Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding

1989 • 281 citations

Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells.

1990 • 280 citations

Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.

1990 • 183 citations

Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytes

1989 • 179 citations

Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells.

1990 • 169 citations

Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.

1990 • 149 citations

Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells

1988 • 119 citations

Identification of protein phosphatase 2A as the major tyrosine hydroxylase phosphatase in adrenal medulla and corpus striatum: evidence from the effects of okadaic acid

1989 • 103 citations

Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation.

1992 • 102 citations

Inhibition of protein phosphatases by okadaic acid induces AP1 in human T cells

1991 • 94 citations

Relationship of c-myc expression to differentiation and proliferation of HL-60 cells.

1985 • 90 citations

Apparent “activation” of protein kinases by okadaic acid class tumor promoters

1989 • 87 citations

Regulation of c-jun expression and AP-1 enhancer activity by granulocyte-macrophage colony-stimulating factor.

1991 • 68 citations

Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases.

1990 • 66 citations

Transcriptional and post-transcriptional regulation of c-fos expression by the tumor promoter okadaic acid.

1991 • 65 citations

Bryostatin induces changes in protein kinase C location and activity without altering c-myc gene expression in human promyelocytic leukemia cells (HL-60).

1987 • 64 citations

Multiple doses of diacylglycerol and calcium ionophore are necessary to activate AP-1 enhancer activity and induce markers of macrophage differentiation.

1990 • 60 citations

Mitotic arrest and enhanced nuclear protein phosphorylation in human leukemia K562 cells by okadaic acid, a potent protein phosphatase inhibitor and tumor promoter

1991 • 55 citations

Differing modulation of protein kinase C by bryostatin 1 and phorbol esters in JB6 mouse epidermal cells.

1988 • 52 citations

Upstream regions of thec-junpromoter regulate phorbol ester-induced transcription in U937 leukemic cells

1992 • 33 citations

Regulation of the p58GTA cell division control-related protein kinase during phorbol 12-myristate 13-acetate-induced terminal differentiation of U937 cells.

1992 • 5 citations