Adenosine and Cardioprotection in the Diseased Heart

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.

1986 • 7,740 citations

Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions

1992 • 3,708 citations

Flow-induced release of endothelium-derived relaxing factor

1986 • 1,379 citations

Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.

1991 • 1,346 citations

Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow

1963 • 1,015 citations

Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy.

1975 • 835 citations

Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

1986 • 821 citations

Catecholamine cardiotoxicity

1985 • 692 citations

Cardiovascular purinoceptors

1990 • 666 citations

Hypoxic Dilation of Coronary Arteries Is Mediated by ATP-Sensitive Potassium Channels

1990 • 600 citations

Two distinct adenosine-sensitive sites on adenylate cyclase.

1977 • 574 citations

Neurohormonal interactions and adaptations in congestive heart failure.

1988 • 540 citations

Increased circulating cytokines in patients with myocarditis and cardiomyopathy.

1994 • 525 citations

Release of Adenosine from Ischemic Brain

1974 • 514 citations

Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.

1983 • 467 citations

Intravenous pretreatment with A1-selective adenosine analogues protects the heart against infarction.

1992 • 457 citations

Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog.

1978 • 417 citations

Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells.

1986 • 416 citations

Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of the endothelium and the no-reflow phenomenon.

1987 • 378 citations

Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture

1980 • 334 citations

Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. A 31P NMR magnetization transfer study.

1985 • 286 citations

Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.

1978 • 253 citations

Regulation of coronary blood flow

1975 • 250 citations

Adenosine, the heart, and coronary circulation.

1991 • 249 citations

Energy metabolism in reperfused heart muscle: Metabolic correlates to return of function

1985 • 221 citations

Quantification of [Ca2+]i in perfused hearts. Critical evaluation of the 5F-BAPTA and nuclear magnetic resonance method as applied to the study of ischemia and reperfusion.

1990 • 217 citations

Plasma Adenosine Levels Increase in Patients With Chronic Heart Failure

1997 • 212 citations

Regulation of adenosine formation by the heart.

1986 • 209 citations

The coronary endothelium: a highly active metabolic barrier for adenosine

1985 • 207 citations

Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia

1977 • 202 citations

Ischemic preconditioning increases adenosine release and 5'-nucleotidase activity during myocardial ischemia and reperfusion in dogs. Implications for myocardial salvage.

1993 • 201 citations

Actions of adenosine and isoproterenol on isolated mammalian ventricular myocytes.

1983 • 199 citations

Role of adenosine in hyperemic response of coronary blood flow in microembolization

1986 • 193 citations

Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-alpha production and protect mice against endotoxin challenge.

1993 • 192 citations

Adenosine inhibits exocytotic release of endogenous noradrenaline in rat heart: a protective mechanism in early myocardial ischemia.

1987 • 191 citations

Regulation of Ion Channels by ABC Transporters That Secrete ATP

1995 • 174 citations

Supply-to-demand ratio for oxygen determines formation of adenosine by the heart

1986 • 171 citations

Blockade of the ATP-sensitive potassium channel modulates reactive hyperemia in the canine coronary circulation.

1991 • 163 citations

Adenosine triphosphate compartmentation in living hearts: a phosphorus nuclear magnetic resonance saturation transfer study

1979 • 162 citations

Ionic basis for the antagonism between adenosine and isoproterenol on isolated mammalian ventricular myocytes.

1984 • 150 citations

Adenosine metabolism and myocardial preservation Consequences of adenosine catabolism on myocardial high-energy compounds and tissue blood flow

1980 • 149 citations

Relationship between coronary flow and adenosine production and release

1974 • 148 citations

Facilitation by Adenosine of the Action of Insulin on the Accumulation of Adenosine 3′:5′‐Monophosphate, Lipolysis, and Glucose Oxidation in Isolated Fat Cells

1974 • 147 citations

Differential effects of adenosine and nitroglycerin on the action potentials of large and small coronary arteries.

1979 • 145 citations

Influence of ribose, adenosine, and "AICAR" on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog.

1985 • 145 citations

Effect of ischemic preconditioning on interstitial purine metabolite and lactate accumulation during myocardial ischemia.

1994 • 142 citations

Infarct size-limiting effect of ischemic preconditioning is blunted by inhibition of 5'-nucleotidase activity and attenuation of adenosine release.

1994 • 137 citations

Role of adenosine and its interaction with adrenoceptor activity in ischaemic and reperfusion injury of the myocardium

1993 • 135 citations

Adenosine relaxation of isolated vascular smooth muscle

1976 • 131 citations

Contractile dysfunction and ATP depletion after transient calcium overload in perfused ferret hearts.

1988 • 130 citations

Consequences of activation and adenosine-mediated inhibition of granulocytes during myocardial ischemia.

1987 • 130 citations

Studies of 5'-nucleotidase in the perfused rat heart. Including measurements of the enzyme in perfused skeletal muscle and liver.

1976 • 127 citations

Insulin-like Actions of Ribonucleic Acid, Adenylic Acid, and Adenosine

1962 • 124 citations

Role of Activation of Protein Kinase C in the Infarct SizeLimiting Effect of Ischemic Preconditioning Through Activation of Ecto-5′-nucleotidase

1996 • 122 citations

Alpha 1-adrenoceptor activation mediates the infarct size-limiting effect of ischemic preconditioning through augmentation of 5'-nucleotidase activity.

1994 • 121 citations

Endogenous adenosine inhibits platelet aggregation during myocardial ischemia in dogs.

1991 • 114 citations

Adenosine improves recovery of postischemic myocardial function via an adenosine A1 receptor mechanism

1992 • 114 citations

Dipyridamole potentiates the myocardial infarct size-limiting effect of ischemic preconditioning.

1992 • 113 citations

Insulin-dependent diabetes mellitus mortality. The risk of cigarette smoking.

1990 • 110 citations

Myocardial adenosine salvage rates and restoration of ATP content following ischemia

1979 • 103 citations

α ₁ -Adrenoceptor Activation Increases Ecto-5′-Nucleotidase Activity and Adenosine Release in Rat Cardiomyocytes by Activating Protein Kinase C

1995 • 100 citations

Adenosine stimulates guanylate cyclase activity in vascular smooth muscle cells.

1987 • 88 citations

The mechanism of adenosine production in rat polymorphonuclear leucocytes

1983 • 87 citations

Formation of S-adenosylhomocysteine in the heart. I: An index of free intracellular adenosine.

1988 • 85 citations

Alpha 1-adrenoceptor activity regulates release of adenosine from the ischemic myocardium in dogs.

1987 • 84 citations

Sensitivity of glucose uptake and lipolysis of white adipocytes of the rat to insulin and effects of some metabolites

1979 • 81 citations

Endogenous adenosine inhibits P-selectin-dependent formation of coronary thromboemboli during hypoperfusion in dogs.

1998 • 79 citations

Role of oxygen-derived free radicals in myocardial edema and ischemia in coronary microvascular embolization.

1991 • 73 citations

Adrenergic blockade blunts adenosine concentration and coronary vasodilation during hypoxia.

1992 • 73 citations

Uptake and deamination of adenosine by blood species differences, effect of pH, ions, temperature and metabolic inhibitors

1969 • 70 citations

Induction of ecto-5'-nucleotidase of rat cultured mesangial cells by interleukin-1 beta and tumour necrosis factor-alpha.

1990 • 70 citations

Effect of adenosine on calcium uptake by intact and cultured vascular smooth muscle

1982 • 67 citations

Phasic release of adenosine during steady state metabolic stimulation in the isolated guinea pig heart.

1983 • 63 citations

Regulation of cytosol 5′-nucleotidase by adenylate energy charge

1981 • 61 citations

Elevation of plasma adenosine levels may attenuate the severity of chronic heart failure.

1998 • 59 citations

Role of Protein Kinase C-α in Activation of Ecto-5′-nucleotidase in the Preconditioned Canine Myocardium

1997 • 53 citations

Adenosine deaminase attenuates canine coronary vasodilation during systemic hypoxia

1986 • 53 citations

Adenosine-induced hyperemia attenuates myocardial ischemia in coronary microembolization in dogs

1989 • 49 citations

Superoxide dismutase enhances ischemia-induced reactive hyperemic flow and adenosine release in dogs. A role of 5'-nucleotidase activity.

1992 • 45 citations

Stimulation of endothelial adenosine A1 receptors enhances adhesion of neutrophils in the intact guinea pig coronary system

1994 • 44 citations

The Importance of the Transmethylation Pathway for Adenosine Metabolism in the Heart

1987 • 42 citations

Beneficial effects of alpha 1-adrenoceptor activity on myocardial stunning in dogs.

1991 • 42 citations

Increase in myocardial adenine nucleotides induced by adenosine: Dosage, mode of application and duration, species differences

1980 • 41 citations

Adenine nucleotide metabolites are beneficial for recovery of cardiac contractile force after hypoxia

1988 • 40 citations

Ionic Channels and Adenosine in Isolated Heart Cells

1987 • 40 citations

Endothelium-mediated coronary dilatation by adenosine does not depend on endothelial adenylate cyclase activation: studies in isolated guinea pig hearts

1988 • 40 citations

Myocardial S-adenosylhomocysteine hydrolase is important for adenosine production during normoxia

1985 • 40 citations

The effects of an intracoronary infusion of adenosine on cardiac performance, blood supply and on myocardial metabolism in dogs

1970 • 39 citations

Beneficial effects of alpha 2-adrenoceptor activity on ischemic myocardium during coronary hypoperfusion in dogs.

1989 • 39 citations

Mechanisms of Coronary Microvascular Dilation Induced by the Activation of Pertussis Toxin–Sensitive G Proteins Are Vessel-Size Dependent

1997 • 38 citations

Effect of Aminophylline on Myocardial Reactive Hyperemia

1972 • 37 citations

Renin Release during Controlled Hypotension with Sodium Nitroprusside, Nitroglycerin and Adenosine: A Comparative Study in the Dog

1985 • 34 citations

Attenuation of ecto-5'-nucleotidase activity and adenosine release in activated human polymorphonuclear leukocytes.

1993 • 33 citations

Endogenous adenosine blunts beta-adrenoceptor-mediated inotropic response in hypoperfused canine myocardium.

1992 • 31 citations

Coronary vasodilation during global myocardial hypoxia: effects of adenosine deaminase

1988 • 29 citations

Activation of Ecto-5′-nucleotidase by Protein Kinase C Attenuates Irreversible Cellular Injury due to Hypoxia and Reoxygenation in Rat Cardiomyocytes

1996 • 29 citations

Canine coronary vasodepressor responses to hypoxia are abolished by 8-phenyltheophylline

1989 • 27 citations

Adenosine Uptake and Adenine Nucleotide Metabolism by Vascular Endothelium

1983 • 27 citations

Alpha 2-adrenoceptor activity exerts dual control of coronary blood flow in canine coronary artery

1988 • 24 citations

Alpha 2-adrenoceptor stimulation can augment coronary vasodilation maximally induced by adenosine in dogs

1989 • 21 citations

Inhibition of Adenosine-induced Coronary Vasodilatation

1967 • 19 citations

The effects of aminophylline on the increased myocardial blood flow produced by systemic hypoxia or by coronary artery occlusion

1972 • 15 citations

Disparate effects of preconditioning and MLA on 5'-NT and adenosine levels during coronary occlusion

1997 • 13 citations

Effects of dipyridamole on myocardial glucose uptake in the newborn lamb

1986 • 10 citations

Superoxide dismutase enhances both adenosine release and coronary hyperemic flow through protection of 5’-nucleotidase against its degradation during reperfusion following ischemia in dogs

1993 • 6 citations

Effects of adenosine and adenine nucleotides on the diameter of the isolated perfused pig coronary artery

1990 • 5 citations