Mechanisms of drug action in leukemia

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

1953 • 12,496 citations

Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin)

1948 • 1,702 citations

Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds

1957 • 1,528 citations

The structure of ribonucleic acids. 1. Cyclic nucleotides produced by ribonuclease and by alkaline hydrolysis

1952 • 780 citations

The Biological Actions and Therapeutic Applications of the B-Chloroethyl Amines and Sulfides

1946 • 717 citations

THE SYNTHESIS OF 5-FLUOROPYRIMIDINES

1957 • 494 citations

Studies on fluorinated pyrimidines. II. Effects on transplanted tumors.

1958 • 436 citations

Colchicine in Agriculture, Medicine, Biology and Chemistry

1955 • 426 citations

Clinical Evaluation of a New Antimetabolite, 6-Mercaptopurine, in the Treatment of Leukemia and Allied Diseases

1953 • 379 citations

The Biochemistry of the Nucleic Acids

1954 • 340 citations

Antimetabolite-metabolite combination cancer chemotherapy.Effects of intra-arterial methotrexate—intramuscular citrovorum factor therapy in human cancer

1959 • 319 citations

Studies on Condensed Pyrimidine Systems. IX. The Synthesis of Some 6-Substituted Purines

1952 • 297 citations

Studies on fluorinated pyrimidines. IV. Effects on nucleic acid metabolism in vivo.

1958 • 259 citations

INFLUENCE OF HORMONES ON LYMPHOID TISSUE STRUCTURE AND FUNCTION. THE ROLE OF THE PITUITARY ADRENOTROPHIC HORMONE IN THE REGULATION OF THE LYMPHOCYTES AND OTHER CELLULAR ELEMENTS OF THE BLOOD¹

1944 • 250 citations

Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo.

1958 • 247 citations

BIOSYNTHESIS OF THE PURINES

1957 • 237 citations

MYLERAN IN CHRONIC MYELOID LEUKÆMIA RESULTS OF TREATMENT

1953 • 232 citations

Agranulocytosis due to the Occurrence of Leukocyte-Agglutinins

1952 • 217 citations

Experiments with some mouse tumors and leukemias.

1958 • 201 citations

Pharmacology in Medicine

1959 • 200 citations

TRIETHYLENE MELAMINE IN THE TREATMENT OF NEOPLASTIC DISEASE

1951 • 197 citations

Studies in 2-acetylaminofluorene carcinogenesis. III. The utilization of uracil-2-C14 by preneoplastic rat liver and rat hepatoma.

1954 • 196 citations

Incorporation of Halogenated Pyrimidines into the Deoxyribonucleic Acids of Bacterium Coli and its Bacteriophages

1954 • 194 citations

Thiation of Nucleosides. I. Synthesis of 2-Amino-6-mercapto-9-β-D-ribofuranosylpurine (“Thioguanosine”) and Related Purine Nucleosides¹

1958 • 193 citations

NITROGEN MUSTARDS IN THE TREATMENT OF NEOPLASTIC DISEASE

1946 • 183 citations

ANTAGONISTS OF NUCLEIC ACID DERIVATIVES

1951 • 146 citations

13. Nucleotides. Part X. Some observations on the structure and chemical behaviour of the nucleic acids

1952 • 144 citations

THE REACTIONS OF THE “RADIOMIMETIC” ALKYLATING AGENTS WITH MACROMOLECULES IN VITRO

1958 • 143 citations

6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals.

1953 • 139 citations

A study of antimetabolites

1952 • 137 citations

Acth- and cortisone-induced regression of lymphoid tumors in man.A preliminary report

1949 • 136 citations

THE CHEMISTRY AND BIOCHEMISTRY OF PURINE ANALOGS

1954 • 134 citations

THE INFLUENCE OF 11-DEHYDR0-17-HYDR0XYCORTICOSTERONE (COMPOUND E) ON THE GROWTH OF A MALIGNANT TUMOR IN THE MOUSE1¹

1944 • 133 citations

Inhibition of orotidylic acid decarboxylase, a primary site of carcinostasis by 6-azauracil

1958 • 123 citations

Involvement of Atp, 5-Phosphoribosyl-Pyrophosphate and L-Azaserine in the Enzymatic Formation of Glycinamide Ribotide Intermediates in Inosinic Acid Biosynthesis

1955 • 122 citations

STUDIES ON ANALOGS OF PURINES AND PYRIMIDINES

1950 • 122 citations

Clinical Trials of p-(Di-2-chloroethylamine)-phenylbutyric Acid (CB 1348) in Malignant Lymphoma

1955 • 113 citations

Incorporation of Halogenated Pyrimidines into the Deoxyribonucleic Acids of Bacterium Coli and its Bacteriophages

1954 • 108 citations

Cancer Chemotherapy Reports

1959 • 106 citations

Incorporation of Unnatural Pyrimidine Bases into Deoxyribonucleic Acid of Mammalian Cells

1959 • 104 citations

A study of antimetabolites

1952 • 102 citations

The Induction of Resistance to 4-Amino-N ¹⁰ -Methyl-Pteroylglutamic Acid in a Strain of Transmitted Mouse Leukemia

1950 • 95 citations

Azaserine, A New Tumour-Inhibitory Substance: Studies with Crocker Mouse Sarcoma 180

1954 • 95 citations

Pharmacological and initial therapeutic observations on 6-Diazo-5-Oxo-L-Norleucine (Don) in human neoplastic disease

1957 • 91 citations

The comparative utilization of uracil-2-C14 by liver, intestinal mucosa, and Flexner-Jobling carcinoma in the rat.

1957 • 84 citations

EFFECTS OF A FOLIC ACID ANTAGONIST ON NUCLEIC ACID METABOLISM

1952 • 80 citations

Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies.

1958 • 77 citations

Azaserine, A New Tumour-Inhibitory Substance: Isolation and Characterization of Azaserine

1954 • 76 citations

A Comparison of the Effects of Radiation and Radiomimetic Chemicals on the Blood

1955 • 70 citations

THE PURINE METABOLISM OF A 6-MERCAPTOPURINE-RESISTANT LACTOBACILLUS CASEI

1953 • 70 citations

Isolierung neuer Stoffe aus den Samen der Herbstzeitlose Colchicum autumnale L. Substanzen der Herbstzeitlose und ihre Derivate. 12. Mitteilung

1950 • 69 citations

STUDIES ON THE ENZYMATIC FORMATION OF CITROVORUM FACTOR BY STREPTOCOCCUS FAECALIS

1953 • 66 citations

TREATMENT OF LEUKEMIA WITH TRIETHYLENE THIOPHOSPHORAMIDE (THIO-TEPA)

1953 • 66 citations

THE EFFECT OF ADRENAL CORTICAL AND PITUITARY ADRENOTROPIC HORMONES ON TRANSPLANTED LEUKEMIA IN RATS

1944 • 64 citations

Observations on inhibition of nucleic acid synthesis resulting from administration of nitrogen mustard, urethan,. colchicine, 2,6-diaminopurine, 8-azaguanine, potassium arsenite, and cortisone.

1951 • 61 citations

In vivo sensitivity of normal and neoplastic mouse tissues to azaserine.

1957 • 60 citations

Comparison of chlorambucil and Myleran® in chronic lymphocytic and granulocytic leukemia

1959 • 58 citations

Chromatographic studies of purine metabolism. I. The effect of azaserine on purine biosynthesis in E. coli using various C14-labeled precursors

1956 • 57 citations

The Mechanism of Quinidine Purpura

1953 • 56 citations

Effects of Large Doses of Chloramphenicol on Human Subjects

1955 • 55 citations

FUNDAMENTAL MECHANISMS OF ALKYLATION

1958 • 53 citations

STUDIES OF THE URICOGENIC EFFECT OF 2-SUBSTITUTED THIADIAZOLES IN MAN*

1959 • 53 citations

ON THE MECHANISM OF ACTION OF 6‐MERCAPTOPURINE

1954 • 51 citations

Effect of 5-fluorouracil on the incorporation of precursors into nucleic acid pyrimidines

1957 • 51 citations

Studies on the mode of action of azaserine

1956 • 50 citations

Studies on the chemotherapy of leukemia. I. Effect of certain nitrogen mustards and carbamates on transmitted mouse leukemia

1948 • 50 citations

Pyrimidine Studies I. Effect of DON (6-Diazo-5-oxo-l-norleucine) on Incorporation of Precursors into Nucleic Acid Pyrimidines

1958 • 49 citations

MICROBIOLOGICAL EFFECTS OF 6‐MERCAPTOPURINE

1954 • 49 citations

Decreased ribonucleotide pyrophosphorylase activity of Streptococcus faecalis and L1210 leukaemia resistant to purine antagonists

1959 • 43 citations

THE LEUKEMIAS

1957 • 40 citations

TREATMENT OF ACUTE LEUKEMIA

1956 • 38 citations

Treatment of acute leukemia.

1956 • 38 citations

Uracil antagonism and inhibition of mammary adenocarcinoma 755.

1958 • 37 citations

Advances in cancer research

1956 • 37 citations

Effects of 5-Fluorodeoxyuridine and Related Halogenated Pyrimidines on the Sand-Dollar Embryo

1960 • 34 citations

BIOLOGICAL ACTIVITIES OF 6-MERCAPTOPURINE: EFFECTS ON STREPTOCOCCUS FAECALIS

1954 • 34 citations

Thrombocytopenic purpura due to allergy to quinidine

1950 • 34 citations

Sterilization of leukemic cells in vivo and in vitro.

1951 • 33 citations

The biochemistry of the nucleic acids

1952 • 29 citations

Metabolism of resistant mutants of Streptococcus faecalis. III. The action of 6-mercaptopurine.

1958 • 29 citations

Biochemical screening of pyrimidine antimetabolites. III. The testing of drugs against a system with a non-oxidative energy source.

1957 • 28 citations

Comparative Therapeutic Activity of the Nitrogen Mustards and Allied Compounds

1956 • 26 citations

The development and biochemical characterization of resistance to azaserine in a TA 3 ascites carcinoma.

1958 • 26 citations

The effects of 6-mercaptopurine on Lactobacillus casei

1957 • 25 citations

Mechanisms of formylation and hydroxymethylation reactions

1959 • 21 citations

Pyrimidine studies. II. Effect of 5-bromodeoxyuridine and related nucleosides on incorporation of precursors into nucleic acid pyrimidines.

1959 • 18 citations

PARA-AMINOBENZOIC ACID IN LEUKEMIA

1948 • 17 citations

TUMOR‐INHIBITORY EFFECTS OF ALKYLATING AGENTS

1958 • 16 citations

Ciba Foundation Symposium ‐ Chemistry and Biology of Pteridines

1954 • 16 citations

REMISSIONS INDUCED BY CHLORAMBUCIL IN CHRONIC GRANULOCYTIC LEUKEMIA

1958 • 14 citations

Differences between cancers in terms of therapeutic responses.

1956 • 13 citations

Inhibition of Uric Acid Biosynthesis in Birds by o-Diazoacetyl-<scp>l</scp>-Serine (Azaserine) and 6-Diazo-5-Oxo-<scp>l</scp>-Norleucine (DON)

1958 • 12 citations

Chemotherapy of leukemia.III. Further studies on the effect of nitrogen mustards and related compounds on transmitted mouse leukemia

1951 • 11 citations

Ciba Foundation Symposium on Chemistry and Biology of Pteridines

1955 • 10 citations

The leukemias, etiology, pathophysiology and treatment

1958 • 10 citations

Ciba Foundation Symposium on Leukaemia Research

1955 • 8 citations

THE EFFECTS OF POTASSIUM ARSENITE (FOWLER'S SOLUTION) ON THE RESPIRATION AND GLYCOLYSIS OF NORMAL AND LEUKEMIC TISSUES, WITH OBSERVATIONS ON THE ACTION OF MENADIONE, 2-METHYL-1, 4 NAPHTHOQUINONE

1943 • 8 citations

Ciba Foundation Symposium on Leukaemia Research

1955 • 8 citations

The Reaction of Leukemic Patients to Sulfapyridine Administration

1940 • 2 citations