Thyroglobulin structure and function: recent advances

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

New Giemsa method for the differential staining of sister chromatids

1974 • 3,198 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and x-ray-derived accessible sites

1986 • 1,150 citations

Magnesium precipitation of ribonucleoprotein complexes. Expedient techniques for the isolation of undegraded polysomes and messenger ribonucleic acid

1974 • 987 citations

Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence

1986 • 426 citations

Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases

1985 • 364 citations

Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA

1987 • 321 citations

Primary structure of bovine thyroglobulin deduced from the sequence of its 8,431-base complementary DNA

1985 • 272 citations

Control of Thyroglobulin Synthesis and Secretion

1979 • 268 citations

Control of Thyroglobulin Synthesis and Secretion

1979 • 258 citations

The Properties of Thyroglobulin

1960 • 245 citations

Neonatal thyroid screening

1980 • 191 citations

Studies on the Carbohydrate Units of Thyroglobulin

1972 • 189 citations

Hydrophobic basis of packing in globular proteins.

1980 • 175 citations

Occurrence of alpha-D-galactosyl residues in the thyroglobulins from several species. Localization in the saccharide chains of the complex carbohydrate units.

1984 • 172 citations

The nature of the thyroid auto-antibodies present in patients with Hashimoto's thyroiditis (lymphadenoid goitre)

1958 • 163 citations

Thyroid Peroxidase and Thyroxine Biosynthesis

1970 • 157 citations

Recherches sur la préparation et les propriétés de la thyroglobuline pure. I

1948 • 151 citations

Separation of Thyroidal Iodoproteins and Purification of Thyroglobulin by Gel Filtration and Density Gradient Centrifugation

1964 • 148 citations

Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin.

1987 • 147 citations

The structure of carbohydrate unit B of porcine thyroglobulin

1981 • 126 citations

Antagonistic effects of thyrotropin and epidermal growth factor on thyroglobulin mRNA level in cultured thyroid cells

1985 • 118 citations

SEQUENCES OF INTEREST: Molecular Cloning of the Complementary Deoxyribonucleic Acid for Human Thyroid Peroxidase

1987 • 114 citations

A nonsense mutation causes hereditary goitre in the Afrikander cattle and unmasks alternative splicing of thyroglobulin transcripts.

1987 • 111 citations

Analysis of sequence and structure homologies between thyroglobulin and acetylcholinesterase: Possible functional and clinical significance

1986 • 98 citations

The sequence of 967 amino acids at the carboxyl‐end of rat thyroglobulin

1985 • 95 citations

Structure of carbohydrate unit A or porcine thyroglobulin

1981 • 92 citations

Thyroglobulin structure-function. The amino acid sequence surrounding thyroxine.

1983 • 81 citations

Specificity of monoclonal antibodies against human thyroglobulin; comparison with autoimmune antibodies.

1983 • 80 citations

The human thyroglobulin gene: A polymorphic marker localized distal to C-MYC on chromosome 8 band q24

1985 • 76 citations

Thyroglobulin, the major and obligatory exportable protein of thyroid follicle cells, carries the lysosomal recognition marker mannose-6-phosphate.

1987 • 75 citations

Chromatographic Fractionation of Hog Thyroglobulin

1961 • 75 citations

The human thyroglobulin gene is over 300 kb long and contains introns of up to 64 kb

1986 • 71 citations

Thyroglobulin: The Prothyroid Hormone

1984 • 71 citations

The human thyroglobulin gene contains two 15-17 kb introns near its 3′-end

1983 • 71 citations

Characterization of banding patterns of metaphase-prophase G-banded chromosomes and their use in gene mapping

1978 • 69 citations

Structural organization of the 5′ region of the thyroglobulin gene

1987 • 68 citations

The sites of thyroid hormone formation in rabbit thyroglobulin.

1987 • 62 citations

Thyroglobulin interactions with thyroid membranes. Relationship between receptor recognition of N-acetylglucosamine residues and the iodine content of thyroglobulin preparations.

1981 • 62 citations

Transcriptional control of thyroglobulin gene expression by cyclic AMP

1985 • 60 citations

Formation of dehydroalanine residues during thyroid hormone synthesis in thyroglobulin.

1980 • 58 citations

Structure-function relationship in thyroglobulin: amino acid sequence of two different thyroxine-containing peptides from porcine thyroglobulin.

1982 • 57 citations

Preferential Synthesis of Thyroxine from Early Iodinated Tyrosyl Residues in Thyroglobulin

1974 • 55 citations

Sequential reactivity of tyrosyl residues of thyroglobulin upon iodination catalyzed by thyroid peroxidase.

1977 • 53 citations

Synthesis and apical and basolateral secretion of thyroglobulin by thyroid cell monolayers on permeable substrate: Modulation by thyrotropin

1987 • 53 citations

A discrete thyroxine-rich iodopeptide of 20,000 daltons from rabbit thyroglobulin.

1981 • 52 citations

Pathways of Endocytosis in Thyroid Follicle Cells

1984 • 52 citations

Presence of a glucuronic acid-containing carbohydrate unit in human thyroglobulin.

1977 • 50 citations

Thyroglobulin structure-function. Isolation and characterization of a thyroxine-containing polypeptide from bovine thyroglobulin.

1981 • 48 citations

The Importance of Thyroglobulin Structure in Thyroid Peroxidase-Catalyzed Conversion of Diiodotyrosine to Thyroxine¹

1977 • 47 citations

Efficiency of thyroglobulin as a thyroid hormone-forming protein

1973 • 46 citations

Kinetics of Thyroglobulin Iodination and of Hormone Synthesis Catalyzed by Thyroid Peroxidase

1976 • 46 citations

Characterization of phosphate residues on thyroglobulin.

1987 • 45 citations

Cloning of human thyroglobulin complementary DNA

1982 • 45 citations

Defective Thyroglobulin Synthesis in an Experimental Rat Thyroid Tumor

1973 • 43 citations

Localization of the thyroglobulin gene by in situ hybridization to human chromosomes

1985 • 42 citations

[MICROHETEROGENEITY OF THYROGLOBULIN. CHROMATOGRAPHICAL PURIFICATION ON DEAE-CELLULOSE AND INTERPRETATION].

1964 • 42 citations

Secretion of sulfated thyroglobulin.

1986 • 41 citations

Microhétérogénéité de la thyroglobuline. Purification par chromatographie sur diéthylaminoéthyl cellulose et interprétation

1964 • 41 citations

Identification of Polysomes Synthesizing Thyroglobulin

1973 • 40 citations

An Approach to the Structure of Thyroglobulin

1980 • 39 citations

Structural organization of the 3′ half of the rat thyroglobulin gene

1984 • 39 citations

Amino acid sequence of the unique 3,5,3′-triiodothyronine-containing sequence from porcine thyroglobulin

1983 • 38 citations

Molecular weight of thyroglobulin 33 S messenger RNA as determined by polyacrylamide gel electrophoresis in the presence of formamide

1977 • 38 citations

Structure, expression and regulation of the thyroglobulin gene

1985 • 37 citations

The N-acetylglucosamine-specific receptor of the thyroid. Binding characteristics, partial characterization, and potential role.

1987 • 37 citations

Modulation of thyroglobulin messenger RNA level by thyrotropin in cultured thyroid cells

1979 • 37 citations

Comparison of the iodoamino acid distribution in various preparations of hog thyroglobulin with different iodine content and subunit structure

1974 • 37 citations

Structural organization of the bovine thyroglobulin gene and of its 5′‐flanking region

1987 • 37 citations

Cloning of Four DNA Fragments Complementary to Human Thyroglobulin Messenger RNA

1981 • 36 citations

Antigenic determinants of human thyroglobulin differentiated using antigen fragments.

1985 • 36 citations

The amino acid sequence of a tryptic glycopeptide from human thyroglobulin

1968 • 35 citations

A fresh look at an old thyroid disease: euthyroid and hyperthyroid nodular goiter

1982 • 35 citations

Thyroglobulin Messenger Ribonucleic Acid Translation in vitro

1977 • 35 citations

[Amino acid composition of thyroglobulin from different animal species].

1966 • 34 citations

Structural organization of the 5' region of the human thyroglobulin gene

1984 • 34 citations

Construction of recombinant plasmids containing rat thyroglobulin mRNA sequences

1982 • 33 citations

Effect of Tunicamycin on Thyroglobulin Secretion

1982 • 33 citations

Quantification of thyroglobulin messenger RNA byIn situ hybridization in. Differentiated thyroid cancers difference between well-differentiated and moderately differentiated histologic types

1985 • 31 citations

Thyroglobulin entering into molecular biology

1984 • 31 citations

Molecular Cloning of the 8000‐Base Thyroglobulin Structural Gene

1982 • 30 citations

Inhibition of N-linked oligosaccharide processing does not prevent the secretion of thyroglobulin. A study with swainsonine and deoxynojirimycin

1986 • 29 citations

Phosphorylated high mannose-type and hybrid-type oligosaccharide chains of human thyroglobulin isolated from malignant thyroid tissue

1985 • 29 citations

COMPOSITION EN ACIDES AMINES DE LA THYROGLOBULINE DE DIFFERENTES ESPECES ANIMALES

1966 • 27 citations

Thyrotrophin and cyclic AMP regulation of thyroglobulin gene expression in cultured porcine thyroid cells

1988 • 27 citations

Thyroglobulin gene activation by thyrotropin and cAMP in hormonally depleted FRTL-5 thyroid cells

1986 • 26 citations

Alternative splicing may be responsible for heterogeneity of thyroglobulin structure

1989 • 26 citations

In vitro synthesis of 300 oo M_r rat thyroglobulin subunit

1982 • 26 citations

Molecular weight of the thyroglobulin messenger RNA of sheep thyroid gland

1977 • 25 citations

cAMP dependent and independent regulation of thyroglobulin synthesis by two clones of the OVNIS 6H thyroid cell line

1987 • 24 citations

Restriction mapping of synthetic thyroglobulin structural gene as a means of investigating thyroglobulin structure

1980 • 23 citations

Thyroid hormonogenesis. Identification of a sequence containing iodophenyl donor site(s) in calf thyroglobulin.

1987 • 23 citations

Similar Hormone-Rich Peptides from Thyroglobulins of Five Vertebrate Classes*

1984 • 21 citations

Studies on the structures of the normal and abnormal goat thyroglobulin genes

1989 • 20 citations

Studies on the Posttranslational Migration and Processing of Thyroglobulin: Use of Inhibitors and Evaluation of the Role of Phosphorylation*

1986 • 20 citations

In vitro and in vivo iodination of human thyroglobulin in relation to hormone release

1983 • 19 citations

Relation between thyroid peroxidase, H2O2 generating system and NADPH-dependent reductase activities in thyroid particulate fractions

1985 • 18 citations

Precursor‐product relationship between the 26‐kDa and 18‐kDa fragments formed by iodination of human thyroglobulin

1984 • 17 citations

Quantitativein SituHybridization of³H-Labeled Complementary Deoxyribonucleic Acid (cDNA) to the Messenger Ribonucleic Acid of Thyroglobulin in Human Thyroid Tissues*

1983 • 17 citations

Identification of thyroglobulin mRNA sequences in the nucleus and the cytoplasm of cultured thyroid cells: A post-transcriptional effect of thyrotropin

1983 • 17 citations

Mapping of human thyroglobulin gene on the long arm of chromosome 8 by in situ hybridization

1985 • 16 citations

Characterization of a hormonogenic domain from human thyroglobulin

1986 • 16 citations

Differences in iodinated peptides and thyroid hormone formation after chemical and thyroid peroxidase-catalyzed iodination of human thyroglobulin

1983 • 15 citations

Thyroid peroxidase‐induced thyroid hormone synthesis in relation to thyroglobulin structure

1979 • 15 citations

The structure of a naturally occuring 10K polypeptide derived from the amino terminus of bovine thyroglobulin

1984 • 15 citations

In vitro studies of the thyroglobulin degradation pathway: endocytosis and delivery of thyroglobulin to lysosomes, release of thyroglobulin cleavage products — iodotyrosines and iodothyronines

1989 • 14 citations

The Use of Hybridoma Antibodies to Probe the Antigenic Determinants of Thyroglobulin

1982 • 14 citations

Specificity of thyroglobulin interactions with thyroid cells and membranes

1983 • 13 citations

Prediction of the secondary structure of the carboxy-terminal third of rat thyroglobulin

1985 • 13 citations

Monoclonal antibodies to hog thyroglobulin recognizing disulfide-dependent conformational structures

1984 • 12 citations

Studies on the antigenicity of human thyroglobulin

1983 • 12 citations

Molecular Cloning of Bovine Thyroglobulin Complementary DNA

1980 • 12 citations

Isolation and characterization of a fragment of rat thyroglobulin gene

1982 • 9 citations

Posttranslational modification of prothyroid hormone

1983 • 8 citations

Expression du gène de thyroglobuline dans les cellules thyroïdiennes en culture : régulation par la thyrotropine

1981 • 5 citations

Identification of recombinant plasmids containing DNA sequences derived from the 3? end of ovine thyroglobulin mRNA

1982 • 4 citations

Deleted Work

1955 • 0 citations