Molecular Biology and Medicine

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

1953 • 12,496 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES

1944 • 3,183 citations

A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase

1975 • 2,622 citations

Sequential tests for the detection of linkage.

1955 • 1,590 citations

Cloning the Differences Between Two Complex Genomes

1993 • 1,301 citations

Molecular Configuration in Sodium Thymonucleate

1953 • 1,209 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Artificial transmutation of the gene

1996 • 966 citations

Human gene therapy comes of age

1992 • 927 citations

Molecular Structure of Nucleic Acids: Molecular Structure of Deoxypentose Nucleic Acids

1953 • 912 citations

DNA Restriction Enzyme from E. coli

1968 • 816 citations

Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types

2017 • 770 citations

The amino-acid sequence in the phenylalanyl chain of insulin. 1. The identification of lower peptides from partial hydrolysates

1951 • 766 citations

Targeted oncogene activation by site-specific recombination in transgenic mice.

1992 • 687 citations

Tissue- and site-specific DNA recombination in transgenic mice.

1992 • 651 citations

Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia

1994 • 562 citations

Prospects for Human Gene Therapy

1984 • 548 citations

A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

1993 • 443 citations

Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy

1993 • 439 citations

Identification of mutations in regions corresponding to the two putative nucleotide (ATP)-binding folds of the cystic fibrosis gene.

1990 • 433 citations

Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice

1993 • 400 citations

Mutations in Barley Induced by X-Rays and Radium

1928 • 381 citations

Localization of the malignant hyperthermia susceptibility locus to human chromosome 19ql2–13.2

1990 • 377 citations

Restriction and modification enzymes and their recognition sequences

1981 • 317 citations

A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia

1991 • 313 citations

Gene therapy for cancer

1994 • 244 citations

A brief history of gene therapy

1992 • 236 citations

Nucleotide Sequence Specificity of Restriction Endonucleases

1979 • 199 citations

Structure and function of nucleic acids as cell constituents.

1951 • 191 citations

Gene therapy for cancer

1992 • 154 citations

Amino acid residues lining the chloride channel of the cystic fibrosis transmembrane conductance regulator.

1994 • 146 citations

Genomic mismatch scanning: a new approach to genetic linkage mapping

1993 • 138 citations

Expression of the human beta-globin gene following retroviral-mediated transfer into multipotential hematopoietic progenitors of mice.

1988 • 119 citations

The amino-acid sequence in the glycyl chain of insulin.

1952 • 93 citations

The human ryanodine receptor gene: its mapping to 19q13.1, placement in a chromosome 19 linkage group, and exclusion as the gene causing myotonic dystrophy.

1990 • 77 citations

Specific T cell receptor gene rearrangements at the site of muscle degeneration in Duchenne muscular dystrophy.

1994 • 71 citations

Progress Toward Human Gene Therapy

1993 • 55 citations

Mammalian artificial chromosomes: a new tool for gene therapy.

1994 • 48 citations

Large Linkage Analysis in 100 Families with Autosomal Recessive Spinal Muscular Atrophy (SMA) and 11 CEPH Families Using 15 Polymorphic Loci in the Region 5q11.2-q13.3

1994 • 43 citations

Molecular genetics of hemophilia A in man (factor VIII deficiency).

1987 • 39 citations

Molecular and genetic analysis of cystic fibrosis*1

1988 • 33 citations

The Cystic Fibrosis Gene Is Found

1989 • 27 citations

Gene therapy for phenylketonuria

1994 • 20 citations

Gene therapy: here to stay.

1995 • 19 citations

A genetic linkage map of five marker loci in and around the Duchenne muscular dystrophy locus

1989 • 18 citations

New Alzheimer's Gene Found

1995 • 18 citations

Cystic fibrosis gene

1992 • 16 citations

Cystic fibrosis gene therapy

1995 • 14 citations

Gene therapy for respiratory diseases: potential applications and difficulties.

1995 • 7 citations

Carrier detection and prenatal diagnosis in 98 families of haemophilia A by linkage analysis and direct detection of mutations

1991 • 6 citations

The end of the beginning

1993 • 3 citations