Modification of bases in DNA by copper ion-1,10-phenanthroline complexes

Superoxide Dismutase

1969 • 12,578 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

The deoxyribose method: A simple “test-tube” assay for determination of rate constants for reactions of hydroxyl radicals

1987 • 2,350 citations

Purine bases, nucleosides, and nucleotides: aqueous solution redox chemistry and transformation reactions of their radical cations and e- and OH adducts

1989 • 1,215 citations

Nuclease activity of 1,10-phenanthroline-copper ion

1986 • 602 citations

Oxygen-dependent cleavage of DNA by the 1,10-phenanthroline . cuprous complex. Inhibition of Escherichia coli DNA polymerase I.

1979 • 515 citations

Iron Ion-dependent Modification of Bases in DNA by the Superoxide Radical-generating System Hypoxanthine/Xanthine Oxidase

1989 • 363 citations

Hydroxyl free radical is not the main active species in site-specific DNA damage induced by copper (II) ion and hydrogen peroxide

1989 • 354 citations

On the participation of higher oxidation states of iron and copper in fenton reactions

1989 • 333 citations

Damage to the Bases in DNA Induced by Hydrogen Peroxide and Ferric Ion Chelates

1989 • 332 citations

Reactions of low-valent transition-metal complexes with hydrogen peroxide. Are they "Fenton-like" or not? 1. The case of Cu+aq and Cr2+aq

1988 • 239 citations

Cleavage of deoxyribonucleic acid by the 1,10-phenanthroline-cuprous complex. Hydrogen peroxide requirement and primary and secondary structure specificity

1981 • 230 citations

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: A physiologically significant reaction?

1983 • 205 citations

Nuclease activity of 1,10-phenanthroline-copper: kinetic mechanism

1989 • 196 citations

Application of capillary gas chromatography-mass spectrometry to chemical characterization of radiation-induced base damage of DNA: Implications for assessing DNA repair processes

1985 • 160 citations

Hydrogen Peroxide-Induced Base Damage in Deoxyribonucleic Acid

1990 • 134 citations

Degradation of deoxyribonucleic acid by a 1,10-phenanthroline-copper complex: the role of hydroxyl radicals

1980 • 132 citations

Quantitative Measurement of Radiation-Induced Base Products in DNA Using Gas Chromatography-Mass Spectrometry

1989 • 123 citations

Copper-phenanthroline-induced site-specific oxygen-radical damage to DNA. Detection of loosely bound trace copper in biological fluids

1984 • 114 citations

Formation of cytosine glycol and 5,6-dihydroxycytosine in deoxyribonucleic acid on treatment with osmium tetroxide

1986 • 113 citations

Mechanisms of the reactions of some copper complexes in the presence of DNA with superoxide, hydrogen peroxide, and molecular oxygen

1986 • 112 citations

Secondary structure specificity of the nuclease activity of the 1,10-phenanthroline-copper complex.

1984 • 110 citations

The role of superoxide and hydroxyl radicals in the degradation of DNA and deoxyribose induced by a copperphenanthroline complex

1982 • 104 citations

Kinetics and mechanism of the reaction of the bis(1,10-phenanthroline)copper(I) ion with hydrogen peroxide in aqueous solution

1987 • 88 citations

Does the reaction of copper(I) with hydrogen peroxide give hydroxyl radicals? A study of aromatic hydroxylation

1989 • 86 citations

The behaviour of caeruloplasmin in stored human extracellular fluids in relation to ferroxidase II activity, lipid peroxidation and phenanthroline-detectable copper

1985 • 81 citations

Reaction of the aquocopper(I) ion with hydrogen peroxide: evidence against hydroxyl free radical formation

1985 • 81 citations

Sequence specificity of DNA cleavage by bis(1,10-phenanthroline)copper(I)

1988 • 71 citations

[55] Selected-ion mass spectrometry: Assays of oxidative DNA damage

1990 • 62 citations

Cleavage of DNA by the 1,10-phenanthroline-copper ion complex. Superoxide mediates the reaction dependent on NADH and hydrogen peroxide

1981 • 61 citations

What is Unique About Superoxide Toxicity as Compared to Other Biological Reductants? — A Hypothesis

1988 • 43 citations

Non-Caeruloplasmin Copper and Ferroxidase Activity in Mammalian Serum. Ferroxidase Activity and Phenanthroline-Detectable Copper in Human Serum in Wilson's Disease

1989 • 40 citations

Specific binding ofo-phenanthroline at a DNA structural lesion

1988 • 36 citations

Oxidation of Dimethylsulphoxide to Formaldehyde by Oxyhaemoglobin and Oxyleghaemoglobin in the Presence of Hydrogen Peroxide is Not Mediated by “Free” Hydroxyl Radicals

1989 • 19 citations

Deoxyribonucleic acid (DNA) damage induced by bleomycin-Fe(II) in vitro: Formation of 8-hydroxyguanine residues in DNA.

1989 • 18 citations