Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus

Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response

2006 • 983 citations

Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

2006 • 815 citations

Features of systemic lupus erythematosus in Dnase1-deficient mice

2000 • 781 citations

Mutation of DNASE1 in people with systemic lupus erythematosus

2001 • 571 citations

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

2006 • 444 citations

Heterozygous Mutations in TREX1 Cause Familial Chilblain Lupus and Dominant Aicardi-Goutières Syndrome

2007 • 379 citations

Gene-Targeted Mice Lacking the Trex1 (DNase III) 3′→5′ DNA Exonuclease Develop Inflammatory Myocarditis

2004 • 348 citations

When the Message Goes Awry

2001 • 282 citations

Role and fate of PML nuclear bodies in response to interferon and viral infections

2001 • 278 citations

Identification and Expression of the TREX1 and TREX2 cDNA Sequences Encoding Mammalian 3′→5′ Exonucleases

1999 • 252 citations

The Exonuclease TREX1 Is in the SET Complex and Acts in Concert with NM23-H1 to Degrade DNA during Granzyme A-Mediated Cell Death

2006 • 250 citations

Demographic history and linkage disequilibrium in human populations

1997 • 197 citations

The Crystal Structure of TREX1 Explains the 3′ Nucleotide Specificity and Reveals a Polyproline II Helix for Protein Partnering

2007 • 108 citations

Role of viruses in systemic lupus erythematosus and Sjögren syndrome

2001 • 76 citations

Promyelocytic leukemia nuclear bodies are predetermined processing sites for damaged DNA

2006 • 66 citations