Stimulation of PrPC Retrograde Transport toward the Endoplasmic Reticulum Increases Accumulation of PrPSc in Prion-infected Cells

Rab proteins as membrane organizers

2001 • 3,320 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

Prion Protein Biology

1998 • 913 citations

Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins

1987 • 757 citations

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

1991 • 627 citations

Rab9 functions in transport between late endosomes and the trans Golgi network.

1993 • 556 citations

Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform [published erratum appears in J Cell Biol 1995 Jul;130(2):501]

1995 • 541 citations

ER Quality Control: The Cytoplasmic Connection

1997 • 528 citations

Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

1996 • 516 citations

The role of ARF and Rab GTPases in membrane transport

1999 • 496 citations

Structural Clues to Prion Replication

1994 • 469 citations

N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

1991 • 412 citations

Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform

1997 • 388 citations

Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

1999 • 362 citations

Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling.

1996 • 338 citations

Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin.

1995 • 318 citations

Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation

2001 • 291 citations

Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells

2002 • 287 citations

Dynamics and retention of misfolded proteins in native ER membranes

2000 • 277 citations

Synthesis and trafficking of prion proteins in cultured cells.

1992 • 268 citations

The small GTP-binding protein rab6 functions in intra-Golgi transport.

1994 • 251 citations

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

2001 • 247 citations

Successful Transmission of Three Mouse-Adapted Scrapie Strains to Murine Neuroblastoma Cell Lines Overexpressing Wild-Type Mouse Prion Protein

2000 • 234 citations

Rab proteins

1998 • 223 citations

Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cells.

1991 • 198 citations

The Chaperone Protein BiP Binds to a Mutant Prion Protein and Mediates Its Degradation by the Proteasome

2000 • 170 citations

Rab4 affects both recycling and degradative endosomal trafficking

2001 • 167 citations

Proteasomal Degradation and N-terminal Protease Resistance of the Codon 145 Mutant Prion Protein

1999 • 165 citations

GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum

1997 • 163 citations

Intracellular re-routing of prion protein prevents propagation of PrPSc and delays onset of prion disease

2001 • 158 citations

Regulation of Membrane Trafficking

1999 • 155 citations

A Transmembrane Form of the Prion Protein Contains an Uncleaved Signal Peptide and Is Retained in the Endoplasmic Reticululm

2001 • 127 citations

Mutant Prion Proteins Are Partially Retained in the Endoplasmic Reticulum

2001 • 127 citations

Internalization of mammalian fluorescent cellular prion protein and N‐terminal deletion mutants in living cells

2001 • 107 citations

Cellular Phenotyping of Secretory and Nuclear Prion Proteins Associated with Inherited Prion Diseases

2002 • 100 citations

Identification of Intermediate Steps in the Conversion of a Mutant Prion Protein to a Scrapie-like Form in Cultured Cells

1997 • 93 citations

Prion Protein Aggregation Reverted by Low Temperature in Transfected Cells Carrying a Prion Protein Gene Mutation

1997 • 91 citations

The Metabolism and Imaging in Live Cells of the Bovine Prion Protein in Its Native Form or Carrying Single Amino Acid Substitutions

2001 • 67 citations

Kinetics of expression of prion protein in uninfected and scrapie‐infected N₂a mouse neuroblastoma cells

1993 • 37 citations

The cellular prion protein: A new partner of the lectin CBP70 in the nucleus of NB4 human promyelocytic leukemia cells*

2001 • 27 citations