Thrombin specificity

Conformation of Polypeptides and Proteins

1968 • 2,929 citations

Structure of Porcine Cholecystokinin‐Pancreozymin

1968 • 481 citations

Alkylation and Identification of the Histidine Residues at the Active Site of Ribonuclease

1963 • 423 citations

[56] Carbodiimide modification of proteins

1972 • 375 citations

Nomenclature and Symbolism for Amino Acids and Peptides

1984 • 351 citations

D-PHE-PRO-ARGCH2Cl-A selective affinity label for thrombin

1979 • 327 citations

[69] Hirudin as an inhibitor of thrombin

1970 • 311 citations

The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit.

1975 • 292 citations

COVALENT STRUCTURE OF FIBRINOGEN

1983 • 259 citations

Synthetic chromogenic substrates for determination of trypsin, thrombin and thrombin-like enzymes

1972 • 252 citations

Amino acid sequence studies on factor XIII and the peptide released during its activation by thrombin

1974 • 250 citations

[21] Cleavage at glutamic acid with staphylococcal protease

1977 • 246 citations

[14] Thrombin

1976 • 214 citations

Structure of N-terminal Fragments of Fibrinogen and Specificity of Thrombin

1967 • 169 citations

Primary structure of human prethrombin 2 and alpha-thrombin.

1977 • 168 citations

Chemistry and Biology of Thrombin

1978 • 166 citations

[7] Amino acid analysis in the picomole range by precolumn derivatization and high-performance liquid chromatography

1983 • 160 citations

[41] Manual micro-sequence analysis of polypeptides using dimethylaminoazobenzene isothiocyanate

1983 • 153 citations

The functional domain of hirudin, a thrombin‐specific inhibitor

1983 • 151 citations

9 Thrombin and Prothrombin

1971 • 137 citations

The action of thrombin on peptide p-Nitroanilide substrates

1983 • 121 citations

Chemistry and biology of thrombin

1977 • 116 citations

The Purification of Thrombin and Isolation of a Peptide Containing the Active Center Histidine

1971 • 101 citations

Structure of Porcine Secretin. I. Degradation with Trypsin and Thrombin. Sequence of the Tryptic Peptides. The C-Terminal Residue^*

1965 • 96 citations

Mechanism of action of heparin through thrombin on blood coagulation

1975 • 88 citations

The action of Factor Xa on peptide p-nitroanilide substrates: substrate selectivity and examination of hydrolysis with different reaction conditions

1986 • 83 citations

Covalent structures of beta and gamma autolytic derivatives of human alpha-thrombin.

1984 • 82 citations

Fibrinogen to Fibrin Transformation

1967 • 80 citations

The inactivation of thrombin and plasmin by antithrombin III in the presence of Sepharose-heparin

1977 • 80 citations

Proflavine binding within the fibrinopeptide groove adjacent to the catalytic site of human .alpha.-thrombin

1984 • 74 citations

Physical evidence for an apolar binding site near the catalytic center of human α-thrombin

1977 • 73 citations

The site in human antithrombin for functional proteolytic cleavage by human thrombin

1981 • 72 citations

Antithrombin reactions with .alpha.- and .gamma.-thrombins

1979 • 69 citations

Problems in the assay of thrombin using synthetic peptides as substrates

1977 • 61 citations

The chemistry and physiology of the human plasma proteins

1979 • 58 citations

Mechanism of action of thrombin on fibrinogen. Kinetic evidence for involvement of aspartic acid at position P10

1983 • 52 citations

Lipid binding by fragments of apolipoprotein C-III-1 obtained by thrombin cleavage

1977 • 51 citations

The mechanism of the fibrinogen-thrombin reaction

1978 • 47 citations

Action of Thrombin on Ovine, Bovine and Human Pituitary Growth Hormones

1976 • 45 citations

[10] Amino-terminal analysis with dimethylaminoazobenzene isothiocyanate

1983 • 40 citations

Amino-terminal analysis of polypeptide using dimethylaminoazobenzene isothiocyanate

1980 • 40 citations

Mechanism of action of thrombin on fibrinogen

1977 • 40 citations

Mechanism of action of thrombin on fibrinogen. Size of the A.alpha. fibrinogen-like peptide that contacts the active site of thrombin

1980 • 39 citations

The interaction of heparin with human α-thrombin: Effect on the hydrolysis of anilide tripeptide substrates

1979 • 38 citations

The destruction of serine and threonine thiohydantoins during the sequence determination of peptides by 4-N,N-dimethylaminoazobenzene 4′-isothiocyanate

1979 • 36 citations

Cleavage of Rabbit Myelin Basic Protein by Thrombin

1984 • 33 citations

The fragmentation of actin by thrombin. Isolation and characterization of the split products

1975 • 32 citations

Proteolytic specificity of thrombin

1974 • 31 citations

Thrombin specificity

1985 • 30 citations

The covalent differences between bovine alpha- and beta-thrombin. A structural explanation for the changes in catalytic activity.

1979 • 24 citations

1.3. Substrate Structure and Activity Relationship (in English)

1977 • 17 citations

Modulatory effects on proteinase kinetics caused by association of both enzyme and substrate to heparin

1983 • 17 citations

The Enzymic Properties of Thrombin and Factor Xa

1973 • 16 citations

Cleavage of a specific bond in troponin C by thrombin

1978 • 15 citations

The Effect of Glucagon, Epinephrine and Vasopressine on the Plasma Concentration and Renal Excretion of Electrolytes in Man¹

1962 • 11 citations

[17] Zone electrophoresis with polyacrylamide gel

1967 • 6 citations

A cross‐linking mechanism for the heparin‐enhanced antithrombin—thrombin reaction?

1984 • 5 citations