Calpain proteolysis of von Willebrand factor enhances its binding to platelet membrane glycoprotein IIb/IIIa: an explanation for platelet aggregation in thrombotic thrombocytopenic purpura

Unusually Large Plasma Factor VIII: von Willebrand Factor Multimers in Chronic Relapsing Thrombotic Thrombocytopenic Purpura

1982 • 1,105 citations

THROMBOTIC THROMBOCYTOPENIC PURPURA

1966 • 905 citations

Platelets have more than one binding site for von Willebrand factor.

1983 • 459 citations

Immunohistochemistry of vascular lesion in thrombotic thrombocytopenic purpura, with special reference to factor VIII related antigen

1985 • 287 citations

Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets.

1979 • 182 citations

THROMBOTIC THROMBOCYTOPENIC PURPURA

1962 • 120 citations

Detection of a Platelet-Agglutinating Factor in Thrombotic Thrombocytopenic Purpura

1984 • 97 citations

Purification of the factor VIII complex

1984 • 97 citations

Purification of human platelet calcium-activated protease. Effect on platelet and endothelial function.

1983 • 95 citations

Cleavage of human von Willebrand factor by platelet calcium-activated protease

1985 • 80 citations

THROMBOHEMOLYTIC THROMBOCYTOPENIC PURPURA

1954 • 79 citations

Fibrinogen Catabolism: Kinetics of Catabolism following Sudden Elevation of the Pool with Exogenous Fibrinogen

1970 • 69 citations

Calcium-dependent cysteine protease activity in the sera of patients with thrombotic thrombocytopenic purpura

1987 • 58 citations

Structural basis of von Willebrand factor binding to platelet glycoprotein Ib and collagen. Effects of disulfide reduction and limited proteolysis of polymeric von Willebrand factor.

1986 • 46 citations

Studies investigating platelet aggregation and release initiated by sera from patients with thrombotic thrombocytopenic purpura

1987 • 42 citations

Studies investigating platelet aggregation and release initiated by sera from patients with thrombotic thrombocytopenic purpura

1987 • 38 citations

Cleavage of fibrinogen by human platelet calcium-activated protease

1984 • 33 citations

Relationship between platelet aggregating factor and von Willebrand factor in thrombotic thrombocytopenic purpura

1987 • 26 citations

Effect of calcium ion concentration on the ability of fibrinogen and von Willebrand factor to support the ADP-induced aggregation of human platelets

1987 • 23 citations

Immunodepletion of human plasma factor VIII

1980 • 17 citations

Membrane expression of platelet calpain

1990 • 7 citations