Chronic obstructive pulmonary disease as a systemic disease: an epidemiological perspective

Weight Loss Is a Reversible Factor in the Prognosis of Chronic Obstructive Pulmonary Disease

1998 • 1,085 citations

Prognostic Value of Nutritional Status in Chronic Obstructive Pulmonary Disease

1999 • 1,023 citations

Respiratory Viruses, Symptoms, and Inflammatory Markers in Acute Exacerbations and Stable Chronic Obstructive Pulmonary Disease

2001 • 1,008 citations

Midthigh Muscle Cross-Sectional Area Is a Better Predictor of Mortality than Body Mass Index in Patients with Chronic Obstructive Pulmonary Disease

2002 • 821 citations

Prevalence and Characteristics of Nutritional Depletion in Patients with Stable COPD Eligible for Pulmonary Rehabilitation

1993 • 730 citations

Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease.

1996 • 526 citations

Body Weight in Chronic Obstructive Pulmonary Disease: The National Institutes of Health Intermittent Positive-Pressure Breathing Trial

1989 • 515 citations

Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease.

1994 • 487 citations

Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers.

1983 • 462 citations

Acute Exacerbations of Chronic Obstructive Pulmonary Disease Are Accompanied by Elevations of Plasma Fibrinogen and Serum IL-6 Levels

2000 • 446 citations

Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils.

1996 • 440 citations

Oxidants/Antioxidants and COPD

2000 • 421 citations

Role of oxidants/antioxidants in smoking-induced lung diseases

1996 • 414 citations

Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects.

1997 • 409 citations

Nutritional status and mortality in chronic obstructive pulmonary disease.

1996 • 394 citations

Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients.

1996 • 342 citations

Systemic Effects in COPD

2002 • 294 citations

Prognostic value of weight change in chronic obstructive pulmonary disease: results from the Copenhagen City Heart Study

2002 • 272 citations

Elevated Plasma Fibrinogen Associated with Reduced Pulmonary Function and Increased Risk of Chronic Obstructive Pulmonary Disease

2001 • 254 citations

COPD and Osteoporosis

2002 • 221 citations

Circulating Leptin in Patients with Chronic Obstructive Pulmonary Disease

1999 • 206 citations

Inhaled corticosteroids reduce neutrophilic bronchial inflammation in patients with chronic obstructive pulmonary disease

1998 • 179 citations

Systemic anti-inflammatory mediators in COPD: increase in soluble interleukin 1 receptor II during treatment of exacerbations

2001 • 154 citations

Skeletal muscle dysfunction in chronic obstructive pulmonary disease

2001 • 126 citations

The Impact of Oral Corticosteroid Use on Bone Mineral Density and Vertebral Fracture

2002 • 111 citations

An increase of soluble Fas, an inhibitor of apoptosis, associated with progression of COPD

1998 • 103 citations

Peripheral leucocyte count and longitudinal decline in lung function.

1988 • 56 citations

Extrapulmonary effects of chronic obstructive pulmonary disease

2001 • 53 citations

Weight Loss is a Reversible Factor in the Prognosis of Chronic Obstructive Pulmonary Disease

1999 • 52 citations

Quantum proteolysis by neutrophils : implications for pulmonary emphysema in alpha(1)-antitrypsin deficiency

2000 • 39 citations

Long-Term Augmentation Therapy in Twenty Patients with Severe Alpha-1-Antitrypsin Deficiency – Three-Year Follow-Up

1997 • 34 citations

Quantum Proteolysis by Neutrophils

2000 • 20 citations

Increased circulating levels of α₁-antitrypsin and calprotectin are associated with reduced gas diffusion in the lungs

2001 • 19 citations