Interleukin 2 Induces Tumor Necrosis Factor Gene ExpressionIn Vivo

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

Nucleotide sequence of a full-length cDNA for mousecytosketetal β-actin raRNA

1986 • 556 citations

Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2.

1986 • 534 citations

Effect of interleukin 2, interferon-gamma, and mitogens on the production of tumor necrosis factors alpha and beta.

1985 • 492 citations

Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.

1985 • 394 citations

Lung myeloperoxidase as a measure of pulmonary leukostasis in rabbits

1985 • 369 citations

Tumor Necrosis Factor Causes Increased Pulmonary Permeability and Edema: Comparison to Septic Acute Lung Injury

1988 • 338 citations

The Genetic Mapping of a Defective Lps Response Gene in C3H/HeJ Mice

1978 • 284 citations

Epidermal keratin gene expressed in embryos of Xenopus laevis.

1985 • 247 citations

Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosis factor-alpha-induced changes in circulating numbers of neutrophils and lymphocytes.

1987 • 229 citations

Induction of circulating tumor necrosis factor (TNFα) as the mechanism for the febrile response to interleukin-2 (IL-2) in cancer patients

1988 • 210 citations

Circulating cytokines in patients with metastatic cancer treated with recombinant interleukin 2 and lymphokine-activated killer cells.

1988 • 197 citations

Production and clearance of tumor necrosis factor in rats exposed to endotoxin and dexamethasone

1987 • 196 citations

Role of tumor necrosis factor-alpha in lipopolysaccharide-induced pathologic alterations.

1990 • 174 citations

Clinical and immunological effects of recombinant interleukin 2 given by repetitive weekly cycles to patients with cancer.

1988 • 159 citations

Wehi 164 Subclone 13 Assay for Tnf: Sensitivity, Specificity, and Reliability

1990 • 154 citations

In vivo induction of gamma interferon and tumor necrosis factor by interleukin-2 infusion following intensive chemotherapy or autologous marrow transplantation

1989 • 122 citations

In vivo dynamics of murine tumor necrosis factor-alpha gene expression. Kinetics of dexamethasone-induced suppression.

1989 • 115 citations

Mechanisms that regulate the production and effects of tumor necrosis factor-alpha.

1989 • 115 citations

Recombinant Human Tumor Necrosis Factor Produces Hemodynamic Changes Characteristic of Sepsis and Endotoxemia

1989 • 115 citations

Induction of endogenous cytokine-mRNA in circulating peripheral blood mononuclear cells by IL-2 administration to cancer patients.

1989 • 93 citations

Passive immunization against tumor necrosis factor partially abrogates interleukin 2 toxicity.

1989 • 85 citations

Interleukin-2-induced Tumor Necrosis Factor-alpha (TNF-α) Gene Expression in Human Alveolar Macrophages and Blood Monocytes

1989 • 85 citations

Cyclosporin a modulation of tumor necrosis factor gene expression and effects in vitro and in vivo.

1990 • 75 citations

Toxicity of human recombinant interleukin-2 in rats. Pathologic changes are characterized by marked lymphocytic and eosinophilic proliferation and multisystem involvement.

1989 • 68 citations

Tumour necrosis factor production by IL-2-activated macrophages in vitro and in vivo.

1989 • 58 citations

Stimulation of prostaglandin E2 and thromboxane B2 production by human monocytes in response to interleukin-2

1987 • 30 citations

Toxic effects of cytokines in vivo.

1989 • 29 citations

Interleukin-2 and interferon-gamma recruit different subsets of human peripheral blood monocytes to secrete interleukin-1 beta and tumour necrosis factor-alpha.

1989 • 28 citations

Tumor necrosis factor-induced alterations in circulating leukocyte populations

1986 • 21 citations

Interleukin-2 Induced Systemic Toxicity: Induction of Mediators and Immunopharmacologic Intervention

1989 • 17 citations