A major role for the Rho‐associated coiled coil forming protein kinase in G‐protein‐mediated Ca²⁺ sensitization through inhibition of myosin phosphatase in rabbit trachea

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Signal transduction and regulation in smooth muscle

1994 • 1,915 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

ROCK‐I and ROCK‐II, two isoforms of Rho‐associated coiled‐coil forming protein serine/threonine kinase in mice

1996 • 757 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation

1997 • 576 citations

Protein kinase C in the regulation of smooth muscle contraction

1987 • 543 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction.

1992 • 458 citations

Rho effectors and reorganization of actin cytoskeleton

1997 • 379 citations

G-protein-mediated Ca2+ sensitization of smooth muscle contraction through myosin light chain phosphorylation

1991 • 326 citations

G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle.

1991 • 319 citations

Cell calcium and its regulation in smooth muscle

1989 • 295 citations

Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle.

1996 • 280 citations

Cyclic GMP Causes Ca2+ Desensitization in Vascular Smooth Muscle by Activating the Myosin Light Chain Phosphatase

1997 • 263 citations

Translocation of rhoA Associated with Ca2+ Sensitization of Smooth Muscle

1997 • 218 citations

The effects of the Rho‐kinase inhibitor Y‐27632 on arachidonic acid‐, GTPγS‐, and phorbol ester‐induced Ca²⁺‐sensitization of smooth muscle

1998 • 199 citations

A novel mechanism for the Ca(2+)-sensitizing effect of protein kinase C on vascular smooth muscle: inhibition of myosin light chain phosphatase.

1994 • 182 citations

Relaxation of Contracted Rabbit Tracheal and Human Bronchial Smooth Muscle by Y-27632 through Inhibition of Ca^{2 +} Sensitization

1999 • 164 citations

Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments.

1987 • 156 citations

Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells

1989 • 153 citations

Inhibition of RhoA Translocation and Calcium Sensitization by In Vivo ADP-Ribosylation with the Chimeric Toxin DC3B

1997 • 151 citations

Ca²⁺‐independent phosphorylation of myosin in rat caudal artery and chicken gizzard myofilaments

1999 • 140 citations

GTP gamma S-dependent regulation of smooth muscle contractile elements

1992 • 139 citations

Possible role of atypical protein kinase C activated by arachidonic acid in Ca2+ sensitization of rabbit smooth muscle.

1997 • 102 citations

Separate upstream and convergent downstream pathways of G-protein- and phorbol ester-mediated Ca2+ sensitization of myosin light chain phosphorylation in smooth muscle

1996 • 73 citations

Kinetics of Prephosphorylation Reactions and Myosin Light Chain Phosphorylation in Smooth Muscle

1995 • 67 citations

Introduction of high molecular weight (IgG) proteins into receptor coupled, permeabilized smooth muscle

1994 • 59 citations

Modulation of Ca2+ sensitivity in smooth muscle by genistein and protein tyrosine phosphorylation

1995 • 55 citations

Protein Kinase C Increases Force and Slows Relaxation in Smooth Muscle: Evidence for Regulation of the Myosin Light Chain Phosphatase

1996 • 48 citations

Role of protein kinase C in calcium sensitization during muscarinic stimulation in airway smooth muscle

1997 • 42 citations

Bundling of Actin Filaments by Myosin Light Chain Kinase from Smooth Muscle

1994 • 37 citations

Receptor-dependent G protein-mediated Ca2+ sensitization in canine airway smooth muscle

1997 • 33 citations

Down-regulation of G-protein-mediated Ca2+ sensitization in smooth muscle.

1997 • 33 citations

InsP₃, but not novel Ca²⁺ releasers, contributes to agonist‐initiated contraction in rabbit airway smooth muscle

1998 • 28 citations

Modulation of Ca2+ Sensitivity by Agonists in Smooth Muscle

1991 • 27 citations

Agonist synergism in airway smooth muscle contraction.

1996 • 25 citations

Halothane Attenuation of Calcium Sensitivity in Airway Smooth Muscle

1997 • 23 citations

Phospholipase A2 and protein kinase C contribute to myofilament sensitization to 5‐HT in the rabbit mesenteric artery.

1996 • 22 citations