Identification of p21 as a Direct Target of EWS-Fli1 Oncogenic Fusion Protein

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Real time quantitative PCR.

1996 • 6,155 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Cancer Cell Cycles

1996 • 5,379 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

1992 • 1,787 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

CBP/p300 in cell growth, transformation, and development

2000 • 1,712 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

Transcriptional Regulation of the p21(WAF1/CIP1)Gene

1999 • 665 citations

Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells

1975 • 663 citations

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

1995 • 593 citations

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

1993 • 560 citations

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1.

1993 • 501 citations

Butyrate Activates the WAF1/Cip1 Gene Promoter through Sp1 Sites in a p53-negative Human Colon Cancer Cell Line

1997 • 399 citations

p21--Negative Regulator of the Cell Cycle

1996 • 396 citations

Regulation of Histone Acetyltransferases p300 and PCAF by the bHLH Protein Twist and Adenoviral Oncoprotein E1A

1999 • 372 citations

Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage

1996 • 371 citations

Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.

2001 • 354 citations

A Viral Mechanism for Inhibition of p300 and PCAF Acetyltransferase Activity

1999 • 343 citations

Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the Enhanceosome

1998 • 321 citations

EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells.

1997 • 274 citations

p300 Collaborates with Sp1 and Sp3 in p21 / Promoter Activation Induced by Histone Deacetylase Inhibitor

2000 • 169 citations

EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

1997 • 159 citations

Prognostic impact of P53 status in Ewing sarcoma

2000 • 154 citations

Loss of tumorigenicity of Ewing's sarcoma cells expressing antisense RNA to EWS-fusion transcripts.

1995 • 134 citations

Direct interaction of p53 with the Y-box binding protein,YB-1 : A mechanism for regulation of human gene expression

2001 • 125 citations

The Ewing's sarcoma gene product functions as a transcriptional activator.

2001 • 117 citations

Evaluation of prognostic factors in a tumor volume-adapted treatment strategy for localized Ewing sarcoma of bone: The CESS 86 experience

1999 • 117 citations

Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumours.

1993 • 114 citations

EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene.

1996 • 109 citations

Histone Deacetylase Inhibitor Activates the p21/WAF1/Cip1 Gene Promoter through the Sp1 Sites

1999 • 103 citations

p300 Interacts with the Nuclear Proto-Oncoprotein SYT as Part of the Active Control of Cell Adhesion

2000 • 101 citations

EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction

1998 • 100 citations

Differential CDK-inhibitor gene expression in aging human diploid fibroblasts

1996 • 98 citations

Cooperative Interaction of EWS with CREB-binding Protein Selectively Activates Hepatocyte Nuclear Factor 4-mediated Transcription

2003 • 93 citations

Effects of histone acetylation and DNA methylation on p21^WAF1regulation

2002 • 93 citations

Downregulation and forced expression of EWS-Fli1 fusion gene results in changes in the expression of G1regulatory genes

2001 • 92 citations

The Raf-1/MEK/ERK Pathway Regulates the Expression of the p21Cip1/Waf1 Gene in Chondrocytes

1999 • 91 citations

Activation of p53-p21 Pathway in Response to Disruption of Cell-Matrix Interactions

1997 • 79 citations

Ice Rhythms—Core Reveals a Plethora of Climate Cycles

1996 • 79 citations

Correction: Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein

1999 • 72 citations

Cyclic AMP-regulated synthesis of the tissue inhibitors of metalloproteinases suppresses the invasive potential of the human fibrosarcoma cell line HT1080.

1995 • 68 citations

DNA Binding Domain-independent Pathways Are Involved in EWS/FLI1-mediated Oncogenesis

2001 • 66 citations

Sodium butyrate induces differentiation in breast cancer cell lines expressing the estrogen receptor

1988 • 65 citations

Inhibition of CBP-Mediated Protein Acetylation by the Ets Family Oncoprotein PU.1

2002 • 64 citations

Differentiating effect of sodium butyrate on human hepatoma cell lines PLC/PRF/5, HCC‐M and HCC‐T

1991 • 53 citations

EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function

2001 • 47 citations

Activation of the p21Waf1/Cip1Promoter by theetsOncogene Family Transcription Factor E1AF

1997 • 36 citations

Correction: Delayed early embryonic lethality following disruption of the murine cyclin A2 gene

1999 • 33 citations

High-dose chemotherapy and autologous peripheral blood stem-cell transfusion after conventional chemotherapy for patients with high-risk Ewing’s tumors

2002 • 23 citations

The establishment and characterization of a peripheral neuroepithelioma cell line in soft tissue of extremity.

1995 • 8 citations

Isolation of a mitomycin-resistant human lung adenocarcinoma cell subline to investigate the modulation by sodium butyrate of cell growth and drug resistance

1993 • 7 citations