The interaction of neurotensin with dopaminergic pathways in the central nervous system: Basic neurobiology and implications for the pathogenesis and treatment of schizophrenia

Chemical Neuroanatomy

1984 • 1,646 citations

The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami

1973 • 1,501 citations

Isolated removal of hypothalamic or other brain nuclei of the rat

1973 • 1,421 citations

The Dopamine Hypothesis of Schizophrenia: A Review*

1976 • 862 citations

Psychopharmacology: A generation of progress

1978 • 785 citations

Neurotensin: Topographical distribution in rat brain by immunohistochemistry

1982 • 538 citations

Characterization of radioimmunoassayable neurotensin in the rat. Its differential distribution in the central nervous system, small intestine, and stomach.

1976 • 537 citations

Neurosecretion and Brain Peptides

1982 • 458 citations

The neurobiology of the nucleus accumbens

1982 • 454 citations

Occurrence of neurotensinlike immunoreactivity in subpopulations of hypothalamic, mesencephalic, and medullary catecholamine neurons

1984 • 439 citations

Regional distribution of neurotensin and somatostatin in rat brain

1977 • 408 citations

Eating and Its Disorders.

1984 • 404 citations

Calcium-dependent release of somatostatin and neurotensin from rat brain in vitro

1978 • 352 citations

Neurotensin: immunohistochemical localization in rat central nervous system.

1977 • 341 citations

The regional distribution of somatostatin, substance P and neurotensin in human brain

1981 • 326 citations

Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin

1976 • 312 citations

Neurotensin receptors are located on dopamine-containing neurones in rat midbrain

1981 • 285 citations

Neurotensin-containing cell bodies, fibers and nerve terminals in the brain stem of the rat: Immunohistochemical mapping

1979 • 284 citations

Rat striatal methionine-enkephalin content after chronic treatment with cataleptogenic and noncataleptogenic antischizophrenic drugs.

1978 • 276 citations

Neurotensin receptor localization by light microscopic autoradiography in rat brain

1981 • 270 citations

Neurotensin: Central nervous system effects of a hypothalamic peptide

1977 • 260 citations

Neurotensin: specific binding to synaptic membranes from rat brain.

1977 • 257 citations

Regional and subcellular distributions of brain neurotensin

1976 • 237 citations

Neurotensin blocks certain amphetamine-induced behaviours

1981 • 225 citations

Regional Brain Concentrations of Neuropeptides in Huntington's Chorea and Schizophrenia

1983 • 223 citations

Radioimmunoassay for neurotensin, a hypothalamic peptide.

1976 • 211 citations

Behavioral and neurochemical effects of neurotensin microinjection into the ventral tegmental area of the rat

1983 • 210 citations

Neurotensin, a central nervous system peptide: apparent receptor binding in brain membranes

1977 • 209 citations

Increase of neurotensin content elicited by neuroleptics in nucleus accumbens.

1980 • 207 citations

The sites of origin brain stem neurotensin and serotonin projections to the rodent nucleus raphe magnus

1982 • 199 citations

The Pathophysiologic Basis of Tardive Dyskinesia

1980 • 190 citations

Interactions of neurotensin with brain dopamine systems: biochemical and behavioral studies.

1983 • 184 citations

Neurotensin administered intracisternally inhibits responsiveness of mice to noxious stimuli

1977 • 180 citations

Subnormal CSF levels of neurotensin in a subgroup of schizophrenic patients: normalization after neuroleptic treatment

1982 • 176 citations

Autoradiographic distribution of [3H]neurotensin receptors in rat brain: Visualization by tritium-sensitive film

1982 • 169 citations

Neurotensin microinjection into the nucleus accumbens antagonizes dopamine-induced increase in locomotion and rearing

1984 • 163 citations

Interactions between neurotensin and dopamine in the brain: An overview

1983 • 151 citations

Neurotensin binding to extraneural and neural receptors: comparison with biological activity and structure--activity relationships.

1980 • 142 citations

Extrapyramidal reactions and amine metabolites in cerebrospinal fluid during haloperidol and clozapine treatment of schizophrenic patients

1975 • 138 citations

Neurotensin-dopamine interactions in the CNS

1985 • 133 citations

Neurotensin in vitro markedly reduces the affinity in subcortical limbic ³H‐N‐propylnorapomorphine binding sites*

1983 • 128 citations

The effect of neurotensin on food consumption in the rat

1982 • 124 citations

Distribution, localization and characteristics of neurotensin binding sites in the rat brain

1977 • 121 citations

Monoiodo-[Trp11]neurotensin, a highly radioactive ligand of neurotensin receptors. Preparation, biological activity, and binding properties to rat brain synaptic membranes.

1983 • 117 citations

Neurotensin: Immunohistochemical localization in rat central nervous system

1977 • 116 citations

Behavioral analysis of the effect of substance P injected into the ventral mesencephalon on investigatory and spontaneous motor behavior in the rat

1985 • 116 citations

Pharmacokinetics and metabolism of cytosine arabinoside in the central nervous system.

1982 • 114 citations

Increase in spontaneous motor activity following infusion of neurotensin into the ventral tegmental area

1981 • 114 citations

Regional Distribution of Neurotensin in Human Brain

1982 • 113 citations

Neurotensin neurons in the ventral tegmental area project to the medial nucleus accumbens

1984 • 111 citations

Neurotensin-induced antinociception in mice: antagonism by thyrotropin-releasing hormone.

1981 • 106 citations

MECHANISM OF ACTION OF NEUROLEPTIC DRUGS

1978 • 103 citations

Increase in dopamine metabolites in rat brain by neurotensin.

1982 • 99 citations

Chronic neuroleptic treatment enhances neurotensin receptor binding in human and rat substantia nigra

1984 • 97 citations

Neurotensin: A new ‘reward peptide’

1984 • 91 citations

Coexistence of dopamine and neurotensin in hypothalamic arcuate and periventricular neurons

1983 • 88 citations

Neurotensin stimulates formation of cyclic GMP in murine neuroblastoma clone N1E-115

1984 • 87 citations

Regional distribution of immunoreactive neurotensin in monkey brain

1979 • 83 citations

Neurotensin facilitates dopamine release in vitro from rat striatal slices

1983 • 78 citations

Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin

1982 • 78 citations

Centrally administered neurotensin: Activity in the Julou-Courvoisier muscle relaxation test in mice

1979 • 77 citations

Cholecystokinin octapeptide levels in rat brain are changed after subchronic neuroleptic treatment

1983 • 77 citations

Neurotensin potentiates the potassium-induced release of endogenous dopamine from rat striatal slices

1983 • 73 citations

Inverse relationship between neurotensin receptors and neurotensin-like immunoreactivity in cat striatum

1984 • 71 citations

Loss of high affinity neurotensin receptors in substantia nigra from parkinsonian subjects

1984 • 71 citations

Effects of neuroleptic drugs on brain somatostatin-like-immunoreactivity

1984 • 70 citations

Neurotensin receptors: Autoradiographic localization in rat CNS

1979 • 69 citations

An immunohistochemical study of somatostatin and neurotensin positive neurons in the septal nuclei of the rat brain

1984 • 69 citations

Regional distribution of bombesin and seven other regulatory peptides in the human brain

1984 • 68 citations

Alterations in regional brain concentrations of neurotensin and bombesin in Parkinson's disease

1985 • 68 citations

Neurotensin receptors in the rat striatum: lesion studies

1984 • 67 citations

Mosaic distribution of neurotensin-like immunoreactivity in the cat striatum

1983 • 67 citations

Behavioral analysis of the effect of neurotensin injected into the ventral mesencephalon on investigatory and spontaneous motor behavior in the rat

1985 • 60 citations

Neurotensin affects hyperactivity but not stereotypy induced by pre and post synaptic dopaminergic stimulation

1983 • 58 citations

The effects of kininase II inhibition by SQ 14225 on kidney kallikrein-kinin and prostaglandin systems in conscious dogs

1979 • 57 citations

Neurotensin, a brain and gastrointestinal peptide.

1982 • 57 citations

Cytoprotective effect of centrally administered neurotensin on stress-induced gastric ulcers

1982 • 56 citations

The effects of neuropeptides on discrete-trial conditioned avoidance responding

1982 • 56 citations

Light and electron microscopic immunocytochemistry of neurotensin-like immunoreactive neurons in the rat hypothalamus

1984 • 55 citations

Neurotensin induces catalepsy in mice

1982 • 54 citations

Neurotensin and its amide analogue [Gln4]-neurotensin: effects on brain monoamine turnover

1978 • 53 citations

Effects of lithium and haloperidol administration on the rat brain levels of substance P.

1983 • 51 citations

Neurotensin effects on brain dopaminergic systems

1982 • 48 citations

Ontogeny of Brain Neurotensin in the Rat: A Radioimmunoassay Study

1984 • 48 citations

Localization of neuropeptides in the avian retina: an immunohistochemical analysis.

1982 • 36 citations

Neurotensin interacts with dopaminergic neurons in rat brain

1983 • 33 citations

Distribution and origins of neurotensin-containing fibers in the nucleus ventromedialis hypothalami of the rat: an experimental immunohistochemical study

1983 • 28 citations

Evidence for the existence of a neurotensin-containing pathway from the endopiriform nucleus and the adjacent prepiriform cortex to the anterior olfactory nucleus and nucleus of diagonal band (Broca) of the rat

1983 • 28 citations

HUMAN BRAIN DISTRIBUTION OF NEUROTENSIN IN NORMALS, SCHIZOPHRENICS, AND HUNTINGTON'S CHOREICS*

1982 • 26 citations

Pathophysiologic basis of tardive dyskinesia.

1980 • 20 citations

Increase of striatal Met5-enkephalin-Arg6-Phe7 (YGGFMRF) content elicited by long-term treatment with haloperidol.

1984 • 19 citations

Comparison of the thermoregulatory responses to intracerebroventricularly injected dopamine, noradrenaline and 5-hydroxytryptamine in the goat

1978 • 17 citations

Postmortem measurements of neuropeptides in human brain

1983 • 16 citations

PHARMACOLOGICAL EVIDENCE FOR A HETEROGENEITY OF RECEPTORS UNDERLYING VARIOUS CENTRAL AND PERIPHERAL EFFECTS OF NEUROTENSIN

1982 • 13 citations

Neuropeptide-Dopamine Interactions: Focus on Neurotensin

1986 • 7 citations

An hypothesis of the molecular structure of the dopamine receptor

1981 • 6 citations

Microtopographic distribution of neurotensin and catecholamine concentrations at the level of individual rat brain nuclei

1984 • 6 citations

A comparative study of neurotensin inactivation by brain peptidases from different vertebrate species

1984 • 6 citations

Do neuropeptide systems mediate some of the effects of antipsychotic drugs?

1985 • 5 citations

Effect of neurotensin on dopamine-stimulated locomotor activity in rats

1983 • 1 citations