Characterization of a [Ca2+]i-dependent current in human atrial and ventricular cardiomyocytes in the absence of Na+ and K+

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Rates of diffusional exchange between small cells and a measuring patch pipette

1988 • 712 citations

Inward current channels activated by intracellular Ca in cultured cardiac cells

1981 • 687 citations

Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure.

1992 • 656 citations

Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres.

1978 • 638 citations

Clinical relevance of cardiac arrhythmias generated by afterdepolarizations

1994 • 483 citations

Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres.

1976 • 407 citations

Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres.

1978 • 389 citations

Sustained atrial tachycardia in adult patients. Electrophysiological characteristics, pharmacological response, possible mechanisms, and effects of radiofrequency ablation.

1994 • 368 citations

Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: voltage-clamp and biochemical characterization of the toxin receptor.

1982 • 350 citations

Calcium-activated potassium channels

1987 • 342 citations

Calcium-activated non-specific cation channels

1988 • 282 citations

Calcium-activated chloride current in rabbit ventricular myocytes.

1991 • 279 citations

Kinetics of Ca2+-activated K+ channels from rabbit muscle incorporated into planar bilayers. Evidence for a Ca2+ and Ba2+ blockade.

1983 • 248 citations

Two types of transient outward currents in adult human atrial cells

1987 • 231 citations

Calcium‐activated non‐selective cation channel in ventricular cells isolated from adult guinea‐pig hearts.

1988 • 194 citations

The coexistence in rat muscle cells of two distinct classes of Ca2+-dependent K+ channels with different pharmacological properties and different physiological functions

1984 • 191 citations

Afterdepolarizations and triggered activity

1992 • 176 citations

Properties of the calcium-activated chloride current in heart.

1992 • 169 citations

Intracellular calcium activates a chloride current in canine ventricular myocytes

1994 • 165 citations

Caffeine-induced Ca2+ release activates Ca2+ extrusion via Na+-Ca2+ exchanger in cardiac myocytes

1989 • 164 citations

The role of [Ca2+]i and [Ca2+] sensitization in the caffeine contracture of rat myocytes: measurement of [Ca2+]i and [caffeine]i.

1990 • 157 citations

Depressed transient outward and calcium currents in dilated human atria

1994 • 153 citations

The arrhythmogenic transient inward current iTI and related contraction in isolated guinea‐pig ventricular myocytes.

1987 • 125 citations

Limitations of the whole cell patch clamp technique in the control of intracellular concentrations

1990 • 119 citations

Comparison of subsarcolemmal and bulk calcium concentration during spontaneous calcium release in rat ventricular myocytes.

1995 • 116 citations

Drug‐Induced Afterdepolarizations and Triggered Activity Occur in a Discrete Subpopulation of Ventricular Muscle Cells (M Cells) in the Canine Heart:

1993 • 108 citations

[Ca2+]i transients and [Ca2+]i‐dependent chloride current in single Purkinje cells from rabbit heart.

1993 • 108 citations

Ryanodine releases calcium from sarcoplasmic reticulum in calcium‐tolerant rat cardiac myocytes.

1987 • 104 citations

The Ca2+-dependent slow K+ conductance in cultured rat muscle cells: characterization with apamin.

1982 • 101 citations

Transient inward current in guinea‐pig atrial myocytes reflects a change of sodium‐calcium exchange current.

1988 • 98 citations

Different Compartments of Sarcoplasmic Reticulum Participate in the Excitation-Contraction Coupling Process in Human Atrial Myocytes

1997 • 98 citations

Calculation of time constants for intracellular diffusion in whole cell patch clamp configuration

1988 • 92 citations

Effects of sodium substitutes on transient inward current and tension in guinea‐pig and ferret papillary muscle.

1985 • 89 citations

Spontaneous Myocardial Calcium Oscillations:

1993 • 84 citations

Why does atrial fibrillation occur?

1997 • 82 citations

The arrhythmogenic current ITI in the absence of electrogenic sodium‐calcium exchange in sheep cardiac Purkinje fibres.

1986 • 77 citations

Intracellular calcium

1984 • 74 citations

Contribution of Na+/Ca2+ exchange to action potential of human atrial myocytes

1996 • 73 citations

Caffeine activates a Ca(2+)-permeable, nonselective cation channel in smooth muscle cells.

1994 • 71 citations

Nonselective Cation Channels

1993 • 71 citations

Simultaneous recording of Indo‐1 flourescence and Na⁺/Ca²⁺ exchange current reveals two components of Ca²⁺‐release from sarcoplasmic reticulum of cardiac atrial myocytes

1990 • 65 citations

Properties and modulation of Ca channels in adult human atrial cells

1991 • 62 citations

Calcium current depression in isolated human atrial myocytes after cessation of chronic treatment with calcium antagonists.

1991 • 61 citations

Comparative mechanisms of 4-aminopyridine-resistant Ito in human and rabbit atrial myocytes

1995 • 57 citations

Isolation of single atrial and ventricular cells from the human heart.

1982 • 55 citations

A calcium -activated cation-selective channel in rat cultured Schwann cells

1984 • 55 citations

Dissociation of subsarcolemmal from global cytosolic [Ca2+] in myocytes from guinea‐pig coronary artery.

1996 • 50 citations

Characteristics of the time-dependent slow inward current in adult human atrial single myocytes

1986 • 48 citations

Nonselective cation channels : pharmacology, physiology, and biophysics

1993 • 46 citations

Two components of [Ca2+]i‐activated Cl‐ current during large [Ca2+]i transients in single rabbit heart Purkinje cells.

1995 • 39 citations

Description of a Nonselective Cation Current in Human Atrium

1995 • 37 citations

Reconstitution and characterization of a calcium-activated channel from heart.

1988 • 34 citations

Relationship between the transient inward current and slow inward currents in the sino‐atrial node of the rabbit.

1986 • 29 citations

Calcium-activated transient membrane currents are carried mainly by chloride ions in isolated atrial, ventricular and Purkinje cells of rabbit heart

1998 • 27 citations

Demonstration of an Inward Na⁺‐Ca²⁺ Exchange Current in Adult Human Atrial Myocytes

1996 • 12 citations

Non-selective Cation Channels

2006 • 2 citations