Apparent involvement of phospholipase A2, but not protein kinase C, in the pro-oxidative interactions of clofazimine with human phagocytes

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties.

1982 • 1,008 citations

Oxidants from phagocytes: agents of defense and destruction

1984 • 803 citations

The extinction coefficient of cytochrome c

1962 • 693 citations

A Potential Second Messenger Role for Unsaturated Fatty Acids: Activation of Ca ²⁺ -Dependent Protein Kinase

1984 • 618 citations

The regulation of lipomodulin, a phospholipase inhibitory protein, in rabbit neutrophils by phosphorylation.

1981 • 424 citations

Activation of NADPH-dependent superoxide production in a cell-free system by sodium dodecyl sulfate.

1985 • 356 citations

Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages

1984 • 335 citations

Biological Defense Mechanisms THE EFFECT OF BACTERIA AND SERUM ON SUPEROXIDE PRODUCTION BY GRANULOCYTES

1974 • 309 citations

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

1983 • 292 citations

Protein kinase C and the activation of the human neutrophil NADPH- oxidase

1987 • 268 citations

NADPH oxidase of human neutrophils. Subcellular localization and characterization of an arachidonate-activatable superoxide-generating system.

1987 • 266 citations

A New Series of Phenazines (Rimino-Compounds) With High Antituberculosis Activity

1957 • 254 citations

Calcium-activated, phospholipid-dependent protein kinase from rat brain

1984 • 241 citations

Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C.

1985 • 216 citations

Chemical modification of the histidine residue in phospholipase A2 (Naja naja naja). A case of half-site reactivity.

1977 • 210 citations

Activation of neutrophil NADPH oxidase in a cell-free system. Partial purification of components and characterization of the activation process.

1987 • 202 citations

Subcellular localization of the human neutrophil NADPH oxidase. b-Cytochrome and associated flavoprotein.

1984 • 187 citations

Priming of the respiratory burst of neutrophils by diacylglycerol. Independence from activation or translocation of protein kinase C.

1987 • 112 citations

Lamprene (Clofazimine) in Leprosy

1979 • 106 citations

Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc gamma receptor-mediated superoxide generation in macrophages.

1987 • 98 citations

Differential stimulation of the respiratory burst and lysosomal enzyme secretion in human polymorphonuclear leukocytes by synthetic diacylglycerols.

1986 • 85 citations

Protein kinase C phosphorylates a component of NADPH oxidase of neutrophils

1985 • 71 citations

Relation of human neutrophil phorbol ester receptor occupancy and NADPH- oxidase activity

1982 • 69 citations

Co-activation of protein kinase C and NADPH oxidase in the plasma membrane of neutrophil cytoplasts

1986 • 56 citations

Oxygen metabolism in phagocytes of leprotic patients: enhanced endogenous superoxide dismutase activity and hydroxyl radical generation by clofazimine

1984 • 51 citations

Inhibition of neutrophil superoxide formation by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-4), an inhibitor of protein kinase-C

1986 • 44 citations

Rapid purification of protein kinase C from rat brain

1987 • 43 citations

Drug Potentiation of Macrophage Function

1970 • 40 citations

Enhancement by clofazimine and inhibition by dapsone of production of prostaglandin E2 by human polymorphonuclear leukocytes in vitro

1985 • 39 citations

Effects of clofazimine alone or combined with dapsone on neutrophil and lymphocyte functions in normal individuals and patients with lepromatous leprosy

1982 • 35 citations

Clofazimine-mediated regulation of human polymorphonuclear leukocyte migration by pro-oxidative inactivation of both leukoattractants and cellular migratory responsiveness

1986 • 23 citations

Clofazimine-mediated stimulation of prostaglandin synthesis and free radical production as novel mechanisms of drug-induced immunosuppression

1986 • 23 citations

The action of Clofazimine on the level of lysosomal enzymes of cultured macrophages.

1982 • 22 citations

Stimulation of Macrophage Phagocytosis by Clofazimine

1973 • 18 citations

Signal response transduction in rabbit neutrophil leucocytes

1987 • 16 citations