Endogenous ligands and modulators of the digitalis receptors: Some candidates

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

The influence of some cations on an adenosine triphosphatase from peripheral nerves

1957 • 2,211 citations

Enzymatic Basis for Active Transport of Na⁺ and K⁺ Across Cell Membrane

1965 • 2,008 citations

The Pharmacological Basis of Therapeutics

1971 • 1,765 citations

Benzodiazepine Receptor: Demonstration in the Central Nervous System

1977 • 1,705 citations

Benzodiazepine receptors in rat brain

1977 • 1,459 citations

Structure of a Molluscan Cardioexcitatory Neuropeptide

1977 • 1,055 citations

The Sodium Pump

1975 • 969 citations

The sodium-potassium adenosine triphosphatase: pharmacological, physiological and biochemical aspects.

1975 • 868 citations

Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines

1980 • 866 citations

Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.

1977 • 835 citations

Further investigations on a Mg++ + Na+-activated adenosintriphosphatase, possibly related to the active, linked transport of Na+ and K+ across the nerve membrane

1960 • 799 citations

Cholinergic Mechanisms

1981 • 609 citations

Two molecular forms of (Na+ + K+)-stimulated ATPase in brain. Separation, and difference in affinity for strophanthidin.

1979 • 598 citations

Uptake and metabolism of γ-aminobutyric acid by neurones and glial cells

1975 • 564 citations

A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications.

1978 • 520 citations

THE ACTION OF CARDIAC GLYCOSIDES ON ION MOVEMENTS.

1964 • 454 citations

Endogenous digitalis-like substance in plasma of volume-expanded dogs

1980 • 444 citations

Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptors

1979 • 412 citations

An endogenous morphine-like factor in mammalian brain

1975 • 393 citations

Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side

1978 • 376 citations

The role of Na+,K+-ATPase in the inotropic action of digitalis.

1977 • 335 citations

The gradient hypothesis and other models of carrier-mediated active transport

2005 • 327 citations

The red cell membrane and the transport of sodium and potassium

1966 • 307 citations

The subcellular basis for the mechanism of inotropic action of cardiac glycosides.

1971 • 299 citations

Osmoregulation in Amphibians and Reptiles

1977 • 289 citations

Mechanism of cardiac glycoside inhibition of the (Na+-K+)-dependent ATPase from cardiac tissue

1968 • 288 citations

Characterization of a new photoaffinity derivative of ouabain: labeling of the large polypeptide and of a proteolipid component of the (sodium-potassium ion)-dependent ATPase

1978 • 282 citations

Morphine-like ligand for opiate receptors in human CSF

1975 • 281 citations

Possible involvement of cardiac Na+, K+-adenosine triphosphatase in the mechanism of action of cardiac glycosides.

1969 • 254 citations

The mechanism of acetylcholine release from parasympathetic nerves

1971 • 251 citations

Changes in tissue levels of carnitine and other metabolites during myocardial ischemia and anoxia

1978 • 249 citations

MEMBRANE ADENOSINE TRIPHOSPHATASE AND CATION TRANSPORT

1968 • 246 citations

Studies on sodium-potassium-activated adenosinetriphosphatase. V. Correlation of enzyme activity with cation flux in six tissues

1963 • 235 citations

Studies on sodium-potassium-activated adenosinetriphosphatase. IV. Correlation with cation transport sensitive to cardiac glycosides

1962 • 234 citations

Active Transport of Sodium and Potassium Ions

1980 • 215 citations

A METABOLIC CAUSE FOR ARRHYTHMIAS DURING ACUTE MYOCARDIAL HYPOXIA

1970 • 213 citations

Immunoferritin determination of the distribution of (Na+ + K+) ATPase over the plasma membranes of renal convoluted tubules. I. Distal segment.

1976 • 208 citations

Progress in Biochemical Pharmacology

1967 • 203 citations

Stimulation, by inhibition of (Na⁺‐K⁺‐Mg²⁺)‐activated, ATP‐ase, of acetylcholine release in cortical slices from rat brain

1972 • 196 citations

Sodium transport inhibitor from bovine hypothalamus.

1979 • 194 citations

Nicotinamide is a brain constituent with benzodiazepine-like actions

1979 • 191 citations

Na+-K+-activated adenosinetriphosphatase as a trigger in transmitter release

1978 • 191 citations

Identification of inosine and hypoxanthine as endogenous inhibitors of [3H] diazepam binding in the central nervous system

1978 • 189 citations

Chemical Physiology of Contraction in Body and Heart Muscle

1954 • 188 citations

The Effects of Long Chain Fatty Acids on Sodium Plus Potassium Ion-stimulated Adenosine Triphosphatase of Rat Brain

1971 • 186 citations

Effects of strophanthidin upon contraction and ionic exchange in rabbit ventricular myocardium: Relation to control of active state

1970 • 178 citations

Tritiated Digoxin Binding to (Na ⁺ + K ⁺ )-Activated Adenosine Triphosphatase: Possible Allosteric Site

1968 • 176 citations

Ouabain-receptor interactions in (Na+ + K+)-ATPase preparations from different tissues and species Determination of kinetic constants and dissociation constants

1973 • 175 citations

Widespread Occurrence in Frogs and Toads of Skin Compounds Interacting with the Ouabain Site of Na ⁺ , K ⁺ -ATPase

1980 • 172 citations

Purification and Characterization of a Cardioexcitatory Neuropeptide from the Central Ganglia of a Bivalve Mollusc

1977 • 172 citations

In vitro effects of palmitylcarnitine on cardiac plasma membrane Na,K-ATPase, and sarcoplasmic reticulum Ca2+-ATPase and Ca2+ transport.

1979 • 170 citations

A possible biochemical explanation for the insensitivity of the rat to cardiac glycosides.

1969 • 168 citations

Sodium-dependent uptake of calcium by crab nerve

1968 • 168 citations

Photoaffinity Labeling of the Ouabain-Binding Site on (Na ⁺ + K ⁺ ) Adenosinetriphosphatase

1974 • 160 citations

�ber den biochemischen Wirkungsmodus von Digitalis

1964 • 159 citations

Endogenous digitalis-like activity in mammalian brain.

1979 • 156 citations

Biochemical Mechanism of the Sodium Pump

1979 • 155 citations

Isolation and structure identification of a morphine-like peptide “enkephalin” in bovine brain

1976 • 152 citations

Structural studies of sodium and potassium ion-activated adenosine triphosphatase. The relationship between molecular structure and the mechanism of active transport.

1975 • 149 citations

The effect of ouabain on sodium- and potassium-activated adenosine triphosphatase from the hearts of several mammalian species.

1969 • 145 citations

Membrane Adenosinetriphosphatase: A Digitalis Receptor?

1977 • 143 citations

Commercial ATP containing traces of vanadate alters the response of (Na+ + K+)ATPase to external potassium

1978 • 140 citations

Über die Identität der Ionenpumpen-ATPase in der Zellmembran des Herzmuskels mit einem Digitalis-Rezeptorenzym

1963 • 138 citations

The action of ions and lipoids upon the frog's heart

1913 • 136 citations

Inhibition of bovine heart Na+,K+-ATPase by palmitylcarnitine and palmityl-CoA

1977 • 133 citations

Endogenous ‘ouabain like’ activity in rat brain

1980 • 132 citations

Correlation between the inotropic action of ouabain and its effects on subcellular enzyme systems from canine myocardium.

1970 • 125 citations

The cellular basis of cardiac glycoside action.

1959 • 124 citations

Platelets, Fatty Acids and Thrombosis

1967 • 120 citations

Diphenylhydantoin and Calcium

1973 • 119 citations

Morphology of the granular secretory glands in skin of poison-dart frogs (Dendrobatidae)

1979 • 118 citations

Humoral factors and the sodium-potassium pump in volume expanded hypertension

1979 • 115 citations

Digitalis

1973 • 114 citations

Stability and ligand sensitivity of [3H]ouabain binding to (Na+ + K+)-ATPase

1970 • 108 citations

Membrane adenosine triphosphatase. The effect of potassium on the formation and dissociation of the ouabain-enzyme complex.

1971 • 102 citations

The effect of dialysates and ultrafiltrates of plasma of saline-loaded dogs on toad bladder sodium transport

1970 • 101 citations

Role of negatively charged phospholipids in highly purified (Na+ + K+)-ATPase from rabbit kidney outer medulla. Studies on (Na+ + K+)-activated ATPase, XXXIX

1978 • 98 citations

Phosphatidylinositol as the endogenous activator of the (Na+ + K+)-ATPase in microsomes of rabbit kidney

1978 • 98 citations

Quaternary structure of (Na+ + K+)-dependent adenosine triphosphatase.

1976 • 96 citations

Amino acid sequence of the Anthopleura xanthogrammica heart stimulant, anthopleurin A

1977 • 95 citations

Is the cell membrane Na+, K+ -ATPase enzyme system the pharmacological receptor for digitalis?

1976 • 93 citations

Pharmacology of the molluscan cardioexcitatory neuropeptide FMRFamide

1980 • 92 citations

Effect of Fatty Acids on Contractility and Rhythm of the Heart

1970 • 91 citations

Inhibition of (Na++K+)-stimulated ATPase of heart by fatty acids

1977 • 90 citations

Inhibition of adrenergic cardiac acceleration by cardiac glycosides.

1961 • 86 citations

The Intrinsic Control of Myocardial Contraction — Ionic Factors

1971 • 85 citations

Ouabain receptor interactions in (Na+ + K+)-ATPase preparations. II. Effect of cations and nucleotides on rate constants and dissociation constants

1973 • 85 citations

Quabain: Temporal relationship between the inotropic effect and the in vitro binding to, and dissociation from, (Na++K+)-activated ATPase

1973 • 80 citations

Cardiac Glycosides in the Defensive Secretion of Chrysomelid Beetles: Evidence for Their Production by the Insects

1977 • 79 citations

Effects of vanadate on cardiac contraction and adenylate cyclase

1979 • 75 citations

A polypeptide (AP-A) from sea anemone (Anthopleura xanthogrammica) with potent positive inotropic action.

1976 • 73 citations

Dissociation of the positive inotropic action of digitalis from inhibition of sodium- and potassium-activated adenosine triphosphate.

1973 • 73 citations

The stimulus‐induced release of acetylcholine from synaptosome beds and its calcium dependence

1972 • 73 citations

The Central Nervous System as a Site of Action for the Coronary Vasoconstrictor Effect of Digoxin

1974 • 71 citations

Endogenous digitalis-like activity in the plasma of the toad Bufo marinus

1979 • 69 citations

Free fatty acids and myocardial function in perfused rat hearts

1970 • 68 citations

Evidence for a dissociation between positive inotropic effect and inhibition of the Na+N+-ATPase by ouabain, cassaine and their alkylating derivatives

1974 • 67 citations

Recent advances in studies on cardiac structure and metabolism

1973 • 66 citations

Isolation and Characterization of the Cardiotonic Polypeptide Anthopleurin-A from the Sea Anemone Anthopleura xanthogrammica

1976 • 64 citations

Relationship between myocardial contractility and the effects of digitalis on ionic exchange.

1977 • 64 citations

The role of calcium in the central effects of biogenic amines

1974 • 63 citations

Photoaffinity labeling of the digitalis receptor in the (Sodium + Potassium) - activated adenosinetriphosphatase

1979 • 62 citations

SHORT CHAIN FATTY ACID INHIBITION OF RAT BRAIN Na‐K ADENOSINE TRIPHOSPHATASEI

1968 • 61 citations

The action of cardiotonic steroids on sugar transport in muscle, in vitro

1968 • 59 citations

Studies on cardiotonic steroids from the skin of Japanese toad.

1977 • 58 citations

Facilitation of ouabain binding to (Na+ + K+)-ATPase by vanadate at in vivo concentrations

1979 • 57 citations

Quantitative aspects of the interaction between ouabain and (Na+ + K+)-activated ATPase in vitro

1971 • 57 citations

New aspects of cardiac glycosides

1963 • 57 citations

Localization of the Neurally Mediated Arrhythmogenic Properties of Digitalis

1979 • 57 citations

Mutual Exclusion of ATP, ADP and g-Strophanthin Binding to NaK-ATPase

1971 • 56 citations

The nature of the transport adenosine triphosphatase-digitalis complex. VII. Characteristics of ouabagenin-Na+,K+-adenosine triphosphatase interaction.

1974 • 56 citations

The presence of two (Na+ + K+)-ATPase inhibitors in equine muscle ATP: Vanadate and a dithioerythritol-dependent inhibitor

1978 • 56 citations

Digitalis: A neuroexcitatory drug.

1975 • 54 citations

An inhibitor of sodium transport in the urine of dogs with normal renal function.

1975 • 53 citations

Further Studies on the Existence of a Sensitizing Factor to Pressor Agents in Hypertension

1975 • 52 citations

Two natriuretic substances in extracts of urine from normal man when salt-depleted and salt-loaded

1976 • 52 citations

Negative and positive inotropic action of vanadate on atrial and ventricular myocardium

1979 • 52 citations

Über den Giftstoff der Kröte

1922 • 51 citations

Carotid sinus reflex changes produced by digitalis.

1971 • 49 citations

Steroid structure and function—II. Conformational transmission and receptor binding of medroxyprogesterone acetate

1978 • 47 citations

Two receptor forms for ouabain in sarcolemma-enriched preparations from canine ventricle.

1980 • 47 citations

Progesterone derivative binds to cardiac ouabain receptor and shows dissociation between sodium pump inhibition and increased contractile force

1979 • 45 citations

Regarding the influence of the Organic Constituents of the blood on the Contractility of the Ventricle

1885 • 44 citations

Role of the nervous system in the genesis of cardiac rhythm disorders

1976 • 44 citations

MOVEMENTS OF CALCIUM AND OTHER CATIONS IN ISOLATED CEREBRAL TISSUES¹

1971 • 43 citations

The influence of ouabain on cholinergic responses in the sinoatrial node.

1966 • 43 citations

Inhibition by vanadium of sodium and potassium dependent adenosinetriphosphatase derived from animal and human tissues.

1978 • 43 citations

Ouabain-like activity in toad skin and its implications for endogenous regulation of ion transport

1978 • 42 citations

Kidney transplant biopsies in the diagnosis and management of acute rejection reactions

1976 • 42 citations

Cardiac NaK ATPase activity during positive inotropic and toxic actions of ouabain

1976 • 42 citations

Dissociation of Na+,K+-ATPase inhibition from digitalis inotropy.

1977 • 40 citations

Further Characterization and Evidence for a Precursor in the Formation of Plasma Antinatriferic Factor

1978 • 40 citations

The effect of digitalis on the excitability of autonomic nerves.

1969 • 39 citations

Further studies on the correlation between the inotropic action of ouabain and its interaction with the Na+,K+-adenosine triphosphatase: isolated perfused rabbit and cat hearts.

1974 • 38 citations

Drugs and Enzymes

1965 • 37 citations

Relation between digitalis binding in vivo and inhibition of sodium, potassium-adenosine triphosphatase in canine kidney

1971 • 37 citations

Cardiac stimulant substances

1967 • 36 citations

Role of adrenergic influences in digitalis-induced ventricular arrhythmia

1976 • 36 citations

Chemical physiology of contraction in body and heart muscle

1954 • 36 citations

The effect of ouabain on catecholamine biosynthesis in rat brain cortex slices.

1970 • 34 citations

Regulation by vanadate of ouabain binding to (Na+,K+)-ATPase.

1979 • 34 citations

The complexes of ouabain with sodium- and potassium-activated adenosine triphosphatase formed with various ligands: relationship to the complex formed in the beating heart.

1976 • 33 citations

Flip-flop model of (NaK)-ATPase function.

1973 • 33 citations

Cardiac glycoside receptors in the heart

1975 • 32 citations

Subcortical mechanisms and sensorimotor activities

1975 • 30 citations

THE ACTION OF CARDIAC GLYCOSIDES ON AUTONOMIC GANGLIA

1954 • 28 citations

The nervous system as a site of action for digitalis and antiarrhythmic drugs.

1970 • 28 citations

Effects of vanadate on Na+,K+-ATPase and on the force of contraction in guinea-pig hearts

1979 • 28 citations

Calcium and the excitable cell membrane.

1969 • 27 citations

Der Einflu� des Prednison- und Prednisolonbisguanylhydrazons auf die Na+ + K+-stimulierte Membran-ATPase des Meerschweinchenherzens

1964 • 26 citations

Effects of Liver Fractions on Myocardial Contractility

1957 • 26 citations

Effect of palmitylcarnitine on ouabain binding to Na, K-ATPase,

1979 • 25 citations

Effects of vanadate on ouabain binding and inhibition of (Na+ + K+)-ATPase

1979 • 24 citations

MECHANISM OF NEUROTOXICITY OF CARDIOTONIC GLYCOSIDES

1977 • 24 citations

Dissociation of contractile effect and binding and inhibition of Na+-K+-adenosine triphosphatase by cardiac glycosides in rabbit myometrium.

1974 • 23 citations

Studies on Cardioactive Steroids

1974 • 23 citations

Steroid structure and function I. Conformational transmission in 17α-acetoxy progesterone

1977 • 22 citations

Inhibitory effect of dopamine on acetylcholine release from caudate nucleus.

1977 • 22 citations

Cardenolid‐korksäurehalbester und weitere Bufadienolid‐korksäurehalbester in Ch' an Su. Über Krötengifte, 36. Mitteilung

1970 • 22 citations

A Vasopressor Potentiator for Norepinephrine in Hypertensive Rats

1976 • 21 citations

Interaction of chlormadinone acetate with the ouabain binding site of Na+,K+-ATPase.

1981 • 20 citations

Effect of cardioactive glycosides on a sympathetic ganglion.

1952 • 20 citations

OUABAIN RECEPTOR BINDING OF HYDROXYPROGESTERONE DERIVATIVES

1979 • 20 citations

Prednisolone-3,20-bisguanylhydrazone: Na+,K+-ATPase inhibition and positive inotropic action

1978 • 19 citations

Effects of vanadate on myocardial function

1980 • 19 citations

Cardenolide aus dem chinesischen Krötengift Ch'an Su. Über Krötengifte, 35. Mitteilung

1970 • 19 citations

β-phenylethylamine as a cardiotonic constituent of tissue extracts

1970 • 19 citations

LIPID METABOLISM OF THE HEART AND ARTERIES IN RELATION TO ISCHÆMIC HEART-DISEASE

1973 • 18 citations

Ouabain Induced Seizures: Site of Production and Response to Anticonvulsants

1978 • 18 citations

Progesterone derivatives that bind to the digitalis receptor: structure--activity relationships.

1980 • 18 citations

Eptatretin: A potent cardioactive agent from the branchial heart of the pacific hagfish, Eptatretus stoutii

1963 • 18 citations

Sugar transport in the perifused left atrium: Effects of contraction frequency, digitalis and ionic alterations

1975 • 18 citations

Effects of ouabain on calcium-45 flux in guinea pig cardiac tissue

1978 • 17 citations

Microinjection of Ouabain into Crab Muscle Fibres

1969 • 17 citations

Digitalis toxicity during acute hypoxia in intact conscious dogs.

1975 • 17 citations

On the lack of inotropy of cardiac glycosides on skeletal muscle: A comparison of Na+,K+-ATPases from skeletal and cardiac muscle

1977 • 17 citations

Cardiac Stimulant Action of Extracts of Coelenterates on Rat Atria

1974 • 17 citations

Interactions of cardiac glycosides with cells and membranes Properties and structural aspects of two receptor sites for ouabain in erythrocytes

1978 • 16 citations

Existence of a new vasoactive factor in experimental hypertension.

1978 • 16 citations

Isolation of a Cardiac-Active Principle from Mammalian Tissues

1956 • 16 citations

Significance of NADH-vanadate-oxidoreductase of cardiac and erythrocyte cell membranes

1980 • 15 citations

The isolation and structure of new bufadienolides, 3-(hydrogen suberates) of resibufogenin, cinobufagin and bufalin the structure of the so-called “bufotoxins”

1968 • 14 citations

Stimulation of human cardiac adenylate cyclase by vanadate

1980 • 12 citations

Biochemical Characteristics of the Sodium Pump: Indications for a Half-of-Sites Reactivity of (Na+ + K+)-ATPase

1977 • 12 citations

Regulation of sugar transport in the myocardium: Effects of ouabain in resting and beating isolated guinea pig left atria

1979 • 11 citations

The distribution of a cardiotonic factor, splenitransin, in mammalian tissues

1969 • 11 citations

The effect of stimulating frequency and of ouabain on the intracellular penetration of L-arabinose in rabbit ventricular muscle,

1973 • 10 citations

Prednisolone-3,20-bisguanylhydrazone: The mode of interaction with rat brain sosium and potassium-activated adenosine triphosphatase

1978 • 9 citations

Lipid fractions from liver inhibit specific binding of [3H]ouabain to dog heart

1980 • 8 citations

Specific binding of [3H]ouabain to heart is inhibited by long-chain fatty acids and alcohols

1980 • 7 citations

Mechanisms regulating the membrane transport of sugars in the myocardium.

1974 • 6 citations

Effects of vanadate ions on action potentials and tension development in papillary muscles and cultured heart muscle cells

1980 • 5 citations

Cardiotonic activities of some new type of bufadienolide- and cardenolide-conjugates

1977 • 5 citations

Action of Liver Extracts on Contractility of Isolated Mammalian Heart Muscle

1952 • 5 citations

Effect of a lipid extract of frog skin on short-circuit current and sodium transport of isolated frog skin

1968 • 4 citations

Binding of Ouabain to Na+, K+-Dependent ATPase during the ATPase Reaction: Evidence for a Dimer Structure of the ATPase1

1979 • 4 citations

Receptor for Cardiac Glycosides

1977 • 3 citations

Effects of calcium-free perfusion on excitation-contraction coupling in heart and skeletal muscle.

1976 • 3 citations

[The effects of digitalis and strophanthin on the action potentials of chemoreceptors in glomus caroticum of cats].

1958 • 3 citations

Ouabain Induced Stereotyped Behavior in Rats

1978 • 1 citations

Cardio-active amines found in ox spleen extracts.

1971 • 1 citations