Structure and pharmacology of elapid cytotoxins

Methods in Enzymology , Vol

1966 • 26,261 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

Prediction of protein conformation

1974 • 3,327 citations

Calcium Dependence of Toxic Cell Death: A Final Common Pathway

1979 • 1,478 citations

Chromatography of Proteins. I. Cellulose Ion-exchange Adsorbents

1956 • 1,295 citations

Gel Filtration: A Method for Desalting and Group Separation

1959 • 1,067 citations

Membrane Asymmetry

1977 • 965 citations

Peptides: Chemistry, structure and biology

1977 • 799 citations

Electrogenic sodium pump in nerve and muscle cells.

1972 • 787 citations

A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-Å resolution

1982 • 710 citations

Conformational preferences of amino acids in globular proteins

1978 • 653 citations

Asymmetrical Lipid Bilayer Structure for Biological Membranes

1972 • 606 citations

Primary structure and transmembrane orientation of the murine anion exchange protein

1985 • 552 citations

Relation between various phospholipase actions on human red cell membranes and the interfacial phospholipid pressure in monolayers

1975 • 548 citations

Chemistry and Pharmacology of Polypeptide Toxins in Snake Venoms

1972 • 479 citations

Lectins: Their Multiple Endogenous Cellular Functions

1981 • 431 citations

Nicotinic receptor of acetylcholine: structure of an oligomeric integral membrane protein

1984 • 373 citations

Molecular aspects of band 3 protein-mediated anion transport across the red blood cell membrane

1986 • 350 citations

Are the presynaptic membrane particles the calcium channels?

1981 • 318 citations

Dihydropyridine receptors in muscle are voltage-dependent but most are not functional calcium channels

1985 • 264 citations

The interaction of bee melittin with lipid bilayer membranes

1978 • 256 citations

Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue

1982 • 254 citations

Melittin lysis of red cells

1985 • 240 citations

[15] Phospholipase A2 (phosphatide acylhydrolase, EC 3.1.1.4) from porcine pancreas

1974 • 226 citations

Chemistry of Protein Toxins in Snake Venoms

1979 • 224 citations

Alamethicin, a transmembrane channel

1981 • 216 citations

Conformational Properties of the Neurotoxins and Cytotoxins Isolated from Elapid Snake Venoms

1983 • 213 citations

High resolution and field desorption mass spectrometry studies and revised structures of alamethicins I and II

1977 • 206 citations

Three-dimensional structure of the "long" neurotoxin from cobra venom.

1980 • 201 citations

Magnetic resonance studies of membrane and model membrane systems. VI. Transbilayer asymmetry and surface homogeneity of mixed phospholipids in cosonicated vesicles

1973 • 195 citations

Human erythrocyte anion permeabilities measured under conditions of net charge transfer

1977 • 172 citations

Membrane-active polypeptides from snake venom: Cardiotoxins and haemocytotoxins

1974 • 166 citations

Anion transport systems in the plasma membrane of vertebrate cells

1986 • 163 citations

Penetration of phospholipid monolayers by cardiotoxins

1981 • 153 citations

Pharmacological properties of cardiotoxin isolated from Formosan cobra venom

1968 • 146 citations

Snake toxin secondary structure predictions

1977 • 144 citations

Cardiotoxins from Cobra Venoms: Possible Mechanisms of Action

1985 • 128 citations

Influence of temperature and cholesterol on the rotational diffusion of band 3 in the human erythrocyte membrane

1979 • 125 citations

The lowest conductance state of the alamethicin pore

1980 • 123 citations

Minireview: Calcium-dependent proteolysis in living cells

1981 • 111 citations

Classification of microbial, plant and animal cytolysins based on their membrane-damaging effects on human fibroblasts

1979 • 103 citations

Specific binding of a cardiotoxin from Naja mossambica mossambica to charged phospholipids detected by intrinsic fluorescence

1978 • 100 citations

.kappa.-Bungarotoxin: complete amino acid sequence of a neuronal nicotinic receptor probe

1985 • 97 citations

Differentiation-related differences in the plasma membrane phospholipid asymmetry of myogenic and fibrogenic cells

1983 • 97 citations

The amino acid sequence of cardiotoxin from formosan cobra (Naja naja atra) venom

1970 • 95 citations

The cromolyn binding protein constitutes the Ca2+ channel of basophils opening upon immunological stimulus.

1984 • 92 citations

Die hämolytischen Eigenschaften der membranmodifizierenden Peptidantibiotika Alamethicin, Suzukacillin und Trichotoxin

1977 • 91 citations

Effects of purified cardiotoxins from the Thailand cobra (Naja naja siamensis) on isolated skeletal and cardiac muscle preparations

1982 • 86 citations

The red cell surface revisited

1985 • 85 citations

Dielectric breakdown of the erythrocyte membrane enhances transbilayer mobility of phospholipids

1983 • 84 citations

Asymmetry of lipid organization in cholinergic synaptic vesicle membranes

1983 • 78 citations

The synergism of cardiotoxin and phospholipase A2 in hemolysis

1978 • 78 citations

Complete amino acid sequence of a nonneurotoxic hemolytic protein from the venom of Haemachatus haemachates (African ringhals cobra)

1973 • 75 citations

Mechanism of action of cobra cardiotoxin in the skeletal muscle.

1976 • 73 citations

Neutralizing monoclonal antibody specific for Naja nigricollis toxin .alpha.: preparation, characterization and localization of the antigenic binding site

1982 • 72 citations

Properties of association of cardiotoxin with lipid vesicles and natural membranes A fluorescence study

1978 • 71 citations

How many types of calcium channels exist in neurones?

1985 • 67 citations

Structure-function relationships for cardiotoxins interacting with phospholipids

1982 • 64 citations

Are interactions with phospholipids responsible for pharmacological activities of cardiotoxins?

1983 • 60 citations

Acetylcholine receptors at neuromuscular synapses: phylogenetic differences detected by snake alpha-neurotoxins.

1975 • 60 citations

The Three-Dimensional Structure of Postsynaptic Snake Neurotoxins: Consideration of Structure and Function

1979 • 60 citations

Cell biology: Is there a common design for cell membrane channels?

1986 • 60 citations

The Release of Acetylcholine

1985 • 59 citations

Cobra cardiotoxins

1987 • 57 citations

Characterization of Elapidae snake venom components using optimized reverse-phase high-performance liquid chromatographic conditions and screening assays for .alpha.-neurotoxin and phospholipase A2 activities

1986 • 56 citations

Amino acid sequence of cytotoxin I from the venom of the indian cobra (Naja naja)

1971 • 56 citations

Isolation of phospholipase A2 from sheep erythrocyte membranes in the presence of detergents

1978 • 53 citations

Bacterial cytotoxins, amphotericin B and local anesthetics enhance transbilayer mobility of phospholipids in erythrocyte membranes. Consequences for phospholipid asymmetry

1986 • 52 citations

Erabutoxin b

1985 • 51 citations

Kinetics of erythrocyte lysis by snake venom cardiotoxins

1977 • 49 citations

The ¹H Nuclear‐Magnetic‐Resonance Spectra of Neurotoxin I and Cardiotoxin V^II4 from Naja mossambica mossambica

1978 • 48 citations

Actions of cardiotoxins from the southern Chinese cobra (Naja naja atra) on rat cardiac tissue

1986 • 47 citations

Effect of phospholipase A on actions of cobra venom cardiotoxins on erythrocytes and skeletal muscle

1983 • 45 citations

Conformation of snake toxic polypeptides studied by a method of prediction and circular dichroism

1978 • 43 citations

Snake venom toxins The isolation and purification of three cytotoxin homologues from the venom of the forest cobra (Naja melanoleuca) and the complete amino acid sequence of toxin VII1

1974 • 43 citations

Mechanisms of receptor-mediated transmembrane signalling

1986 • 43 citations

Snake Venom Toxins. The Purification of Toxins V^II1 and V^II2, Two Cytotoxin Homologues from Banded Egyptian Cobra(Naja haje annulifera)Venom, and the Complete Amino Acid Sequence of Toxin V^II1

1973 • 42 citations

Atrotoxin: A Specific Agonist for Calcium Currents in Heart

1985 • 41 citations

Inactivation of (Na+ + K+)-stimulated ATPase by a cytotoxic protein from cobra venom in relation to its lytic effects on cells

1975 • 37 citations

The oxidation of methionine and its effect on the properties of cardiotoxin VII1 from Naja melanoleuca venom

1978 • 37 citations

Classification of elapid snake neurotoxins and cytotoxins according to chain length: Evolutionary implications

1984 • 36 citations

Sequential Individual Resonance Assignments in the ¹H Nuclear‐Magnetic‐Resonance Spectrum of Cardiotoxin V^II 2 from Naja mossambica mossambica

1983 • 35 citations

Photoaffinity derivatives of α‐Bungarotoxin and α‐Naja naja siamensis toxin

1979 • 35 citations

Binding of ringhals venom direct hemolytic factor to erythrocytes and osmotic ghosts of various animal species

1965 • 33 citations

Snake venom toxins the primary structures of two novel cytotoxin homologues from the venom of forest cobra (Naja melanoleuca)

1974 • 31 citations

¹H Nuclear‐Magnetic‐Resonance Studies of the Conformation of Cardiotoxin V^II2 from Naja mossambica mossambica

1981 • 30 citations

Biochemical and pharmacological properties of cardiotoxins isolated from cobra venom

1982 • 30 citations

The influence of melittin on the rotation of band 3 protein in the human erythrocyte membrane

1984 • 30 citations

The Evolution of Toxins Found in Snake Venoms

1979 • 30 citations

The Basic Proteins of Cobra Venom

1968 • 30 citations

Cytolytic Mechanisms: Self-Destruction of Mammalian Cells by Activation of Endogenous Hydrolytic Enzymes

1982 • 29 citations

Polyamine-phospholipid interaction probed by the accessibility of the phospholipidsn-2 ester bond to the action of phospholipase A2

1986 • 26 citations

Acetylcholine receptors of human skeletal muscle: a species difference detected by snake neurotoxins

1985 • 23 citations

Preparation by immunoaffinity chromatography of phospholipase-free cardiotoxins from the venom of the Elapidae snake Naja mossambica mossambica

1980 • 23 citations

Membrane disintegration and hemolysis of human erythrocytes by snake venom cardiotoxin (a membrane-disruptive polypeptide).

1984 • 22 citations

CONFORMATIONAL STABILITY OF A SNAKE CARDIOTOXIN

1977 • 21 citations

Photoaffinity labeling of acetylcholine receptor in millisecond time scale

1984 • 20 citations

The importance of protein structure and conformation in the preparation of phospholipase-free cardiotoxin from snake venom

1977 • 20 citations

Binding of cardiotoxin analogue III from Formosan cobra venom to FL cells

1986 • 20 citations

Semisynthesis and biological properties of the [B24-leucine]-, [B25-leucine]- and [B24-leucine, B25-leucine]-analogues of human insulin

1981 • 20 citations

Lethal protein conformations

1980 • 19 citations

The preparation of phospholipase A2—Free cardiotoxin from snake venom by hydrophobic interaction chromatography

1979 • 18 citations

Photochemically induced nuclear polarization study of exposed tyrosines, tryptophans, and histidines in postsynaptic neurotoxins and in membranotoxins of elapid and hydrophid snake venom

1984 • 18 citations

The influence of lipid composition on the barrier properties of band 3-containing lipid vesicles

1984 • 18 citations

Structure‐activity studies of homologues of short chain neurotoxins from Elapid snake venoms

1984 • 18 citations

Two neutralizing monoclonal antibodies specific for Naja nigricollis cardiotoxin: Preparation, characterization and localization of the epitopes

1986 • 16 citations

The effect of cardiotoxin on (Ca2+ + Mg2+)-ATPase of the erythrocyte and sarcoplasmic reticulum.

1983 • 16 citations

Species Differences in Reversibility of Neuromuscular Blockade by Elapid and Sea Snake Neurotoxins

1976 • 16 citations

ACTIVATION OF SELF-DESTRUCTION AS A MECHANISM OF ACTION FOR CYTOLYTIC TOXINS

1980 • 16 citations

XIII. A contribution to the study of the action of indian cobra venom

1905 • 15 citations

Circular dichroism study of the unfolding-refolding of a cardiotoxin from Taiwan cobra (Naja naja atra) venom

1985 • 15 citations

Studies on the status of disulfide linkages and tyrosine residues in cardiotoxin

1975 • 15 citations

Homology of functionally diverse proteins

1977 • 15 citations

Crystallographic studies of snake venom proteins from Taiwan cobra (Naja nana atra). Cardiotoxin-analogue III and phospholipase A2.

1981 • 14 citations

Action of cobra venom cardiotoxin on chick embryonal fibroblasts transformed with a temperature‐sensitive mutant of Rous sarcoma virus

1985 • 13 citations

Amino acid sequence of a cardiotoxin-like basic polypeptide (CLBP) with low cytotoxic activity isolated from the venom of the Formosan cobra (Naja naja atra).

1985 • 13 citations

�ber die herzwirksame Komponente des Kobragiftes (?Cardiotoxin?)

1958 • 13 citations

The status of tyrosyl residues in a Formosan cobra cardiotoxin

1978 • 13 citations

A possible orientation change of cardiotoxin molecule during its interaction with phospholipid monolayer

1982 • 12 citations

ISOLATION OF CARDIOTOXIN FROM COBRA VENOM (NAJA TRIPUDIANS; MONOCELLATE VARIETY)

1947 • 12 citations

The structural evolution of cobra venom cytotoxins

1987 • 11 citations

[Interaction of cardiotoxin from the venom of the cobra Naja naja oxiana with phospholipid membrane model systems].

1978 • 11 citations

Molecular evolution of snake venom toxins

1977 • 11 citations

The Effect of Neurotoxin, Haemolysin and Choline Esterase Isolated from Cobra Venom on Heart, Blood Pressure and Respiration.

1942 • 11 citations

Effects of Ca2+ and membrane surface charge on the direct lytic activity of cobra cardiotoxin — A membrane spin assay

1978 • 10 citations

Differences in binding of the direct lytic factor (DLF) of cobra venom (Naja naja) to intact red cells and ghosts

1973 • 10 citations

The preparation of 3-nitrotyrosyl derivatives of three elapid venom cardiotoxins

1980 • 10 citations

On the interaction of cobra venom protein cardiotoxins with erythrocytes

1984 • 10 citations

Muscle damage induced by the ionophore A23187 can be prevented by prostaglandin inhibitors and leupeptin

1985 • 9 citations

Sensitivity of cultured embryonic heart cells to cardiotoxin obtained from Naja naja siamensis venom

1975 • 9 citations

The Pharmacology of Phospholipases A2 Isolated from Snake Venoms, with Particular Reference to Their Effects on Neuromuscular Transmission

1982 • 8 citations

Separation of four cardiotoxins of Taiwan cobra (Naja Naja atra) by reversed-phase high-performance liquid chromatography

1982 • 7 citations

Action of cobra venom lytic factor on sialic acid ? Depleted erythrocytes and ghosts

1971 • 6 citations

Species differences in reversibility of neuromuscular blockade by elapid and sea snake neurotoxins

1975 • 4 citations

Modulation of ouabaine sensitive (Na+ + K+) ATPase activity by snake venom constituants

1985 • 2 citations