What information do inhibitors provide about the structure of the hydroquinone oxidation site of ubihydroquinone: Cytochromec oxidoreductase?

Possible molecular mechanisms of the protonmotive function of cytochrome systems

1976 • 1,252 citations

Principles of protein structure

1980 • 1,094 citations

Principles of Protein Structure

1979 • 1,090 citations

Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect

1971 • 980 citations

The protonmotive Q cycle. Energy transduction by coupling of proton translocation to electron transfer by the cytochrome bc1 complex.

1990 • 586 citations

[24] Use of specific inhibitors on the mitochondrial bc1 complex

1986 • 333 citations

Oudemansin, strobilurin A, strobilurin B and myxothiazol: new inhibitors of the bc₁ segment of the respiratory chain with an E‐β‐methoxyacrylate system as common structural element

1981 • 256 citations

Myxothiazol, a new inhibitor of the cytochrome b-c1 segment of the respiratory chain

1981 • 235 citations

Function of the iron-sulfur protein of the cytochrome b-c1 segment in electron-transfer and energy-conserving reactions of the mitochondrial respiratory chain

1981 • 206 citations

The reaction of antimycin with a cytochrome b preparation active in reconstitution of the respiratory chain

1970 • 186 citations

The chromone inhibitor stigmatellin ‐ binding to the ubiquinol oxidation center at the C‐side of the mitochondrial membrane

1985 • 172 citations

Cytochrome bc1 complex [2Fe-2S] cluster and its interaction with ubiquinone and ubihydroquinone at the Qo site: a double-occupancy Qo site model

1992 • 171 citations

Electron and Proton Transfer in Chemistry and Biology

1992 • 167 citations

An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc1 complex.

1984 • 151 citations

Complete inhibition of electron transfer from ubiquinol to cytochrome b by the combined action of antimycin and myxothiazol

1981 • 149 citations

Mutational analysis of the mouse mitochondrial cytochrome b gene

1988 • 147 citations

Molecular Basis for Resistance to Myxothiazol, Mucidin (Strobilurin A), and Stigmatellin

1989 • 145 citations

Characterisation of binding of the methoxyacrylate inhibitors to mitochondrial cytochrome c reductase

1988 • 144 citations

The allosteric binding of antimycin to cytochrome b in the mitochondrial membrane

1972 • 123 citations

Binding of HQNO to beef-heart sub-mitochondrial particles

1977 • 115 citations

Inhibition of electron transfer by 3-alkyl-2-hydroxy-1,4-naphthoquinones in the ubiquinol-cytochrome c oxidoreductases of Rhodopseudomonas sphaeroides and mammalian mitochondria. Interaction with a ubiquinone-binding site and the Rieske iron-sulfur cluster.

1983 • 104 citations

An analogue of ubiquinone which inhibits respiration by binding to the iron-sulfur protein of the cytochrome b-c1 segment of the mitochondrial respiratory chain.

1982 • 104 citations

Determination of the redox properties of the Rieske [2Fe‐2S] cluster of bovine heart bc₁ complex by direct electrochemistry of a water‐soluble fragment

1992 • 104 citations

Further studies on the rieske ironsulfur center in mitochondrial and photosynthetic systems: A pK on the oxidized form

1976 • 103 citations

Mutations conferring resistance to quinol oxidation (Qz) inhibitors of the cyt bc1 complex of Rhodobacter capsulatus.

1989 • 101 citations

Phospholipid specificity of bovine heart bc₁ complex

1990 • 97 citations

The mode of action of stigmatellin, a new inhibitor of the cytochrome b-c1 segment of the respiratory chain

1984 • 92 citations

Characterization of four herbicide-resistant mutants of Rhodopseudomonas viridis by genetic analysis, electron paramagnetic resonance, and optical spectroscopy

1989 • 87 citations

Inhibitor effects on redox-linked protonations of the b haems of the mitochondrial bc1 complex

1990 • 83 citations

Analysis of inhibitor binding to the mitochondrial cytochrome c reductase by fluorescence quench titration

1991 • 80 citations

Significance of the “Rieske” iron-sulfur protein for formation and function of the ubiquinol-oxidation pocket of mitochondrial cytochrome c reductase (bc1 complex).

1991 • 78 citations

Inhibition of electron transfer in the cytochromeb-c 1 segment of the mitochondrial respiratory chain by a synthetic analogue of ubiquinone

1980 • 76 citations

Mutants of ubiquinol-cytochrome c2 oxidoreductase resistant to Qo site inhibitors: consequences for ubiquinone and ubiquinol affinity and catalysis

1990 • 71 citations

Interaction of Zn²⁺ with the bovine‐heart mitochondrial bc₁ complex

1991 • 68 citations

Point mutation in cytochrome b of yeast ubihydroquinone:cytochrome‐c oxidoreductase causing myxothiazol resistance and facilitated dissociation of the iron‐sulfur subunit

1992 • 66 citations

Intragenic suppressors reveal long distance interactions between inactivating and reactivating amino acid replacements generating three-dimensional constraints in the structure of mitochondrial cytochrome b.

1990 • 56 citations

Pseudo-wild type revertants from inactive apocytochrome b mutants as a tool for the analysis of the structure/function relationships of the mitochondrial ubiquinol-cytochrome c reductase of Saccharomyces cerevisiae.

1990 • 55 citations

Structure/function relationships in mitochondrial cytochrome b revealed by the kinetic and circular dichroic properties of two yeast inhibitor‐resistant mutants

1991 • 48 citations

Studies on the effect of stigmatellin derivative on cytochrome band the Rieske iron‐sulfur cluster of cytochrome c reductase from bovine heart mitochondria.

1988 • 45 citations

On the interaction of mitochondrial complex III with the Rieske iron-sulfur protein (subunit V)

1991 • 43 citations

Organization and function of cytochromeb and ubiquinone in the cristae membrane of beef heart mitochondria

1986 • 41 citations

Analysis of the structures of the subunits of the cytochrome bc₁ complex from beef heart mitochondria

1986 • 40 citations

Effect of substituents of the benzoquinone ring on electron-transfer activities of ubiquinone derivatives

1990 • 27 citations

Comparison of structure of quinone redox site in the mitochondrial cytochrome‐bc₁ complex and photosystem II (Q_B site)

1992 • 26 citations

Two substitutions at the same position in the mitochondrial cytochrome b gene of S. cerevisiae induce a mitochondrial myxothiazol resistance and impair the respiratory growth of the mutated strains abbeit maintaining a good electron transfer activity

1990 • 21 citations

Glycine-231 residue of the mouse mitochondrial protonmotive cytochrome b: mutation to aspartic acid deranges electron transport

1990 • 15 citations

Analysis of the binding of P‐chlorophenyl‐methoxybenzyl‐ketoxime (CPMB‐Oxime) to mitochondrial cytochrome c reductase

1991 • 11 citations