Ratios of Radical to Conservative Amino Acid Replacement are Affected by Mutational and Compositional Factors and May Not Be Indicative of Positive Darwinian Selection

The rapid generation of mutation data matrices from protein sequences

1992 • 6,766 citations

Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.

1986 • 4,940 citations

Atlas of protein sequence and structure

1965 • 4,462 citations

Amino Acid Difference Formula to Help Explain Protein Evolution

1974 • 2,255 citations

Fundamentals of molecular evolution

1991 • 1,721 citations

Evolutionary EST analysis identifies rapidly evolving male reproductive proteins inDrosophila

2001 • 521 citations

Relation between amino acid composition and cellular location of proteins 1 1Edited by F. E. Cohen

1997 • 406 citations

Large-scale search for genes on which positive selection may operate

1996 • 367 citations

Rates of Conservative and Radical Nonsynonymous Nucleotide Substitutions in Mammalian Nuclear Genes

2000 • 349 citations

Positive Darwinian selection promotes charge profile diversity in the antigen-binding cleft of class I major-histocompatibility-complex molecules.

1990 • 287 citations

Rose: generating sequence families.

1998 • 277 citations

Estimation of the Transition/Transversion Rate Bias and Species Sampling

1999 • 212 citations

Adaptive diversification within a large family of recently duplicated, placentally expressed genes

2000 • 147 citations

Molecular Evolution of Transferrin: Evidence for Positive Selection in Salmonids

2001 • 126 citations

Positive and Negative Selection in the DAZ Gene Family

2001 • 111 citations

Molecular Evolution of the teosinte branched Gene Among Maize and Related Grasses

2001 • 101 citations

Rates of nucleotide substitution in sexual and anciently asexual rotifers

2001 • 96 citations

Elevated Rates of Nonsynonymous Substitution in Island Birds

2001 • 93 citations

Origin and Evolution of Viral Interleukin-10 and Other DNA Virus Genes with Vertebrate Homologues

2002 • 91 citations

Estimating the Transition/Transversion Ratio from Independent Pairwise Comparisons with an Assumed Phylogeny

1997 • 63 citations

Neutrality tests of conservative-radical amino acid changes in nuclear- and mitochondrially-encoded proteins

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Transition and transversion rate in the evolution of animal mitochondrial DNA

1986 • 38 citations

Coevolution of the vertebrate integrin alpha- and beta-chain genes.

1992 • 33 citations