Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat

1986 • 1,509 citations

A review of the validity and variability of the Elevated Plus-Maze as an animal model of anxiety

1996 • 1,160 citations

Abstinence Symptomatology and Psychiatric Diagnosis in Cocaine Abusers

1986 • 1,134 citations

Ethopharmacological analysis of rat behavior on the elevated plus-maze

1994 • 823 citations

Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: A structure-activity study

1990 • 462 citations

The comparative efficacy of buspirone and diazepam in the treatment of anxiety

1979 • 426 citations

Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: A comparative study with dorsal raphe neurons

1988 • 329 citations

Changes in Mood, Craving, and Sleep During Short-term Abstinence Reported by Male Cocaine Addicts

1990 • 284 citations

5HT drugs in animal models of anxiety

1993 • 261 citations

Brain corticotropin-releasing factor mediates ‘anxiety-like’ behavior induced by cocaine withdrawal in rats

1995 • 256 citations

Differential effects of 5-hydroxytryptamine1A selective drugs on the 5-HT behavioral syndrome

1986 • 244 citations

Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug

1986 • 231 citations

Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine.

1995 • 221 citations

Serotonergic mechanisms in the behavioral effects of buspirone and gepirone

1986 • 194 citations

An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone

1989 • 192 citations

Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats

1999 • 190 citations

Risk Assessment Behaviour: Evaluation of Utility in the Study of 5-HT-Related Drugs in the Rat Elevated Plus-Maze Test

1997 • 188 citations

The actions of nicotine and cocaine in a mouse model of anxiety

1989 • 188 citations

Animal model for investigating the anxiogenic effects of self-administered cocaine

1991 • 180 citations

Clinical phenomenology and neurobiology of cocaine abstinence: a prospective inpatient study

1991 • 179 citations

Biological bases of anxiety

1998 • 157 citations

Behavioural characterization and amounts of brain monoamines and their metabolites in mice lacking histamine H1 receptors

1998 • 157 citations

Chronic cocaine enhances serotonin autoregulation and serotonin uptake binding

1992 • 153 citations

Anxiogenic effects of acute and chronic cocaine administration: Neurochemical and behavioral studies

1992 • 144 citations

Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT, ipsapirone and buspirone in the rat

1993 • 143 citations

β-adrenergic antagonists attenuate withdrawal anxiety in cocaine-and morphine-dependent rats

1993 • 115 citations

Lack of long-term monoamine depletions following repeated or continuous exposure to cocaine

1988 • 111 citations

Endogenous acetylcholine in the dorsal hippocampus reduces anxiety through actions on nicotinic and muscarinic-sub-1 receptors.

1998 • 104 citations

Anxiogenic properties of cocaine in the rat evaluated with the elevated plus-maze

1992 • 102 citations

Endogenous acetylcholine in the dorsal hippocampus reduces anxiety through actions on nicotinic and muscarinic₁ receptors.

1998 • 99 citations

Anxiogenic behavior in rats during acute and protracted ethanol withdrawal: Reversal by buspirone

1991 • 91 citations

Alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to major depression in humans

1998 • 89 citations

On the elevated plus-maze the anxiolytic-like effects of the 5-HT 1A agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT 1A partial agonist, buspirone, are blocked by the 5-HT 1A antagonist, WAY 100635

1997 • 86 citations

The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes

1998 • 79 citations

Treatment of cocaine-induced panic disorder

1989 • 78 citations

The behavioral and biochemical effects of thioperamide, a histamine H3-receptor antagonist, in a light/dark test measuring anxiety in mice

1993 • 67 citations

Effects of DN-2327, a new anxiolytic, diazepam and buspirone on exploratory activity of the rat in an elevated plus-maze

1991 • 66 citations

Cocaine Abuse and its Treatment

1984 • 64 citations

The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and suppresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats

2000 • 63 citations

Lack of neurochemical evidence for neurotoxic effects of repeated cocaine administration in rats on brain monoamine neurons

1991 • 60 citations

Anxiolytic-like behavior after lesion of the tuberomammillary nucleus E2-region

1998 • 58 citations

Anxiogenic properties of cocaine withdrawal

1987 • 58 citations

Biosynthesis of dopamine and serotonin in the rat brain after repeated cocaine injections: A microdissection mapping study

1993 • 56 citations

Effects of cocaine on conflict behavior in the rat

1989 • 55 citations

5‐Hydroxytryptamine_1A Receptor Agonists in Animal Models of Depression and Anxiety

1992 • 55 citations

Evidence for alterations in presynaptic serotonergic function during withdrawal from chronic cocaine in rats

1995 • 47 citations

The in vivo pharmacological profile of histamine (H₁) antagonists in the rat

1982 • 47 citations

Effects of (S) - α -fluoromethylhistidine and metoprine on locomotor activity and brain histamine content in mice

1992 • 46 citations

Serotonin Neurotransmission in Cocaine Sensitizationa

1992 • 43 citations

Drug-Induced Ego States. I. Cocaine: Phenomenology and Implications

1984 • 43 citations

Discriminative stimulus properties of cocaine related to an anxiogenic action

1981 • 43 citations

Acute cocaine effects on stereotypy and defense: an ethoexperimental approach

1998 • 34 citations

Generalization of a restraint-induced discriminative stimulus to cocaine in rats

1998 • 33 citations

Behavioural consequences of cocaine withdrawal in rats

1994 • 29 citations

Evidence for a postsynaptic action of the serotonergic anxiolytics: Ipsapirone, indorenate and buspirone

1992 • 26 citations

Repeated injections of cocaine inhibit the serotonergic regulation of prolactin and renin secretion in rats

1992 • 26 citations

Dimenhydrinate dependence and withdrawal.

1990 • 22 citations

Chronic cocaine differentially affects diazepam’s anxiolytic and anticonvulsant actions

2000 • 21 citations

Dimenhydrinate Abuse among Adolescentsa

1993 • 17 citations

Dimenhydrinate: evidence for dependence and tolerance.

1988 • 16 citations

INTERACTION OF COCAINE WITH CHLORDIAZEPOXIDE ASSESSED BY MOTOR ACTIVITY IN MICE

1977 • 16 citations

The pattern of locomotor activity after cocaine treatment in the rat

1996 • 15 citations