Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell–dependent B cell responses

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Germinal Centers

1994 • 1,680 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Dendritic cell regulation of TH1-TH2 development

2000 • 1,136 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Distinct dendritic cell subsets differentially regulate the class of immune responseinvivo

1999 • 1,013 citations

B7-H3: A costimulatory molecule for T cell activation and IFN-γ production

2001 • 916 citations

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

The B7 Family of Ligands and Its Receptors: New Pathways for Costimulation and Inhibition of Immune Responses

2002 • 884 citations

T-cell co-stimulation through B7RP-1 and ICOS

1999 • 758 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

1998 • 710 citations

ICOS is essential for effective T-helper-cell responses

2001 • 666 citations

ICOS is critical for CD40-mediated antibody class switching

2001 • 646 citations

Dendritic cell lineage, plasticity and cross-regulation

2001 • 613 citations

The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

2000 • 507 citations

B7-1 and B7-2 Have Overlapping, Critical Roles in Immunoglobulin Class Switching and Germinal Center Formation

1997 • 499 citations

B7h, a Novel Costimulatory Homolog of B7.1 and B7.2, Is Induced by TNFα

1999 • 440 citations

Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells

2000 • 423 citations

Affinity maturation without germinal centres in lymphotoxin-α-deficient mice

1996 • 322 citations

Importance of ICOS–B7RP-1 costimulation in acute and chronic allograft rejection

2001 • 317 citations

ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses

2001 • 273 citations

The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE

2001 • 264 citations

CD28 is required for germinal center formation.

1996 • 251 citations

Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation.

1997 • 225 citations

Polyethylene Glycol-Modified GM-CSF Expands CD11bhighCD11chigh But Not CD11blowCD11chigh Murine Dendritic Cells In Vivo: A Comparative Analysis with Flt3 Ligand

2000 • 209 citations

Enhancement of CD8+ T Cell Responses by ICOS/B7h Costimulation

2001 • 149 citations

Separable effector T cell populations specialized for B cell help or tissue inflammation

2001 • 138 citations

Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS

2000 • 132 citations

Impaired CD28-mediated Interleukin 2 Production and Proliferation in Stress Kinase SAPK/ERK1 Kinase (SEK1)/Mitogen-activated Protein Kinase Kinase 4 (MKK4)-deficient T Lymphocytes

1997 • 128 citations

Inducible Costimulator Regulates Th2-Mediated Inflammation, but Not Th2 Differentiation, in a Model of Allergic Airway Disease

2001 • 127 citations

B7H Costimulates Clonal Expansion of, and Cognate Destruction of Tumor Cells by, CD8+ T Lymphocytes In Vivo

2001 • 120 citations

Immune Responses in MHC Class II-Deficient MICE

1995 • 101 citations

Constitutive Expression of the B7h Ligand for Inducible Costimulator on Naive B Cells Is Extinguished after Activation by Distinct B Cell Receptor and Interleukin 4 Receptor–mediated Pathways and Can Be Rescued by CD40 Signaling

2002 • 83 citations

ICOS Ligand Costimulation Is Required for T-Cell Encephalitogenicity

2001 • 78 citations

CD40 ligand induction on T cell subsets by peptide-presenting B cells: implications for development of the primary T and B cell response.

1997 • 60 citations

The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion

1997 • 33 citations

Costimulation of Memory T-Cells by ICOS: A Potential Therapeutic Target for Autoimmunity?

2001 • 33 citations

Impaired germinal centre formation and humoral immune response in the absence of CD28 and interleukin‐4

2002 • 28 citations

Affinity Maturation of the Primary Response by V Gene Diversification

1998 • 12 citations

Biotherapeutic Targets for the Treatment of Allergic Airway Disease

2000 • 6 citations