Crystal structure of human Charcot–Leyden crystal protein, an eosinophil lysophospholipase, identifies it as a new member of the carbohydrate-binding family of galectins

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

SCOP: A structural classification of proteins database for the investigation of sequences and structures

1995 • 6,372 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Galectins. Structure and function of a large family of animal lectins.

1994 • 1,487 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

The Three-Dimensional Crystal Structure of the Catalytic Core of Cellobiohydrolase I from Trichoderma reesei

1994 • 626 citations

Evidence for export of a muscle lectin from cytosol to extracellular matrix and for a novel secretory mechanism.

1990 • 462 citations

Structure of pentameric human serum amyloid P component

1994 • 459 citations

Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 Å

1979 • 444 citations

Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning

1987 • 441 citations

Mechanism of membrane damage mediated by human eosinophil cationic protein

1986 • 415 citations

Identification of galectin-3 as a factor in pre-mRNA splicing.

1995 • 397 citations

The Phosphorylation State of Eucaryotic Initiation Factor 2 Alters Translational Efficiency of Specific mRNAs

1989 • 393 citations

Structure of S-lectin, a developmentally regulatedvertebrate beta-galactoside-binding protein.

1994 • 269 citations

X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.

1993 • 267 citations

Structure of a Legume Lectin with an Ordered N-Linked Carbohydrate in Complex with Lactose

1991 • 264 citations

A human lectin, galectin-3 (epsilon bp/Mac-2), stimulates superoxide production by neutrophils.

1995 • 263 citations

The Mac-2 antigen is a galactose-specific lectin that binds IgE.

1989 • 251 citations

Structures of Free and Inhibited Human Secretory Phospholipase A ₂ from Inflammatory Exudate

1991 • 251 citations

Structure of Phaseolin at 2·2 Å Resolution

1994 • 250 citations

Regulation of secretion and surface expression of Mac-2, a galactoside-binding protein of macrophages.

1994 • 246 citations

X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.

1993 • 245 citations

Endogenous muscle lectin inhibits myoblast adhesion to laminin.

1991 • 224 citations

Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides

1994 • 213 citations

Crystal structure of Vibrio cholerae neuraminidase reveals dual lectin-like domains in addition to the catalytic domain

1994 • 198 citations

Molecular and active-site structure of a Bacillus 1,3-1,4-beta-glucanase.

1993 • 187 citations

Effect of amino acid substitution by sited-directed mutagenesis on the carbohydrate recognition and stability of human 14-kDa beta-galactoside-binding lectin.

1991 • 187 citations

Eosinophil granule proteins in peripheral blood granulocytes

1992 • 183 citations

Apical secretion of a cytosolic protein by Madin-Darby canine kidney cells. Evidence for polarized release of an endogenous lectin by a nonclassical secretory pathway

1993 • 175 citations

.epsilon.BP, a .beta.-galactoside-binding animal lectin, recognizes IgE receptor (Fc.epsilon.RI) and activates mast cells

1993 • 169 citations

The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs.

1989 • 163 citations

The crystal structure of pea lectin at 6-A resolution.

1982 • 162 citations

Data Collection and Processing

1980 • 143 citations

Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). Similarities to IgE binding proteins and the S-type animal lectin superfamily.

1993 • 131 citations

The crystal structure of pea lectin at 3.0-A resolution.

1986 • 130 citations

Human neutrophils express immunoglobulin E (IgE)-binding proteins (Mac-2/epsilon BP) of the S-type lectin family: role in IgE-dependent activation.

1993 • 128 citations

Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms

1990 • 128 citations

Formation of Charcot-Leyden crystals by human basophils.

1982 • 121 citations

Mature eosinophils stimulated to develop in human cord blood mononuclear cell cultures supplemented with recombinant human interleukin-5. Part I. Piecemeal degranulation of specific granules and distribution of Charcot-Leyden crystal protein.

1991 • 114 citations

An endogenous lectin, galectin-3 (ϵBP / Mac-2), potentiates IL-1 production by human monocytes

1994 • 110 citations

Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to a distinct crystalloid-free granule population in mature human eosinophils

1988 • 109 citations

Crystal Structure and Site-directed Mutagenesis of Bacillus macerans Endo-1,3 –1,4- β-glucanase

1995 • 104 citations

Biochemical characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase).

1984 • 104 citations

HERA—A program to draw schematic diagrams of protein secondary structures

1990 • 96 citations

IgE‐binding molecules (Mac‐2/ϵBP) expressed by human eosinophils. Implication in IgE‐dependent eosinophil cytotoxicity

1993 • 95 citations

Comparative analyses of pentraxins: implications for protomer assembly and ligand binding

1994 • 93 citations

Cloning of the bovine pancreatic cholesterol esterase/lysophospholipase

1989 • 87 citations

Charcot-Leyden crystal protein and eosinophil granule major basic protein in sputum of patients with respiratory diseases.

1984 • 86 citations

Eosinophils : biological and clinical aspects

1993 • 80 citations

Soluble 14-kDa beta-galactoside-specific bovine lectin. Evidence from mutagenesis and proteolysis that almost the complete polypeptide chain is necessary for integrity of the carbohydrate recognition domain.

1991 • 79 citations

Calcium ionophore A23187 calcium-dependent cytolytic degranulation in human eosinophils.

1985 • 79 citations

Zur Kenntniss des Bronchial-Asthma

1872 • 73 citations

Eosinophils in Allergy and Inflammation

2019 • 68 citations

Changing the differentiation program of hematopoietic cells: retinoic acid-induced shift of eosinophil-committed cells to neutrophils

1995 • 64 citations

The human eosinophil Charcot-Leyden crystal protein: biochemical characteristics and measurement by radioimmunoassay.

1980 • 60 citations

Further evidence by site-directed mutagenesis that conserved hydrophilic residues form a carbohydrate-binding site of human galectin-1

1994 • 49 citations

The three-dimensional structure of PNGase F, a glycosyl asparaginase from Flavobacterium meningosepticum

1994 • 46 citations

Schistosoma mansoni: Synthesis and release of phospholipids, lysophospholipids, and neutral lipids by schistosomula

1989 • 44 citations

Ultrastructural localization of the Charcot-Leyden crystal protein (lysophospholipase) to granules and intragranular crystals in mature human basophils.

1989 • 39 citations

Eosinophilia and elevated serum levels of eosinophil major basic protein and Charcot-Leyden crystal protein (lysophospholipase) after treatment of patients with Bancroft's filariasis.

1981 • 37 citations

IgE-binding protein. Subcellular location and gene expression in many murine tissues and cells.

1988 • 35 citations

Crystal Structure of Peptide-N4-(N-acetyl-.beta.-D-glucosaminyl)asparagine amidase F at 2.2-.ANG. Resolution

1994 • 30 citations

Monopalmitoylphosphatidylcholine incorporation into human erythrocyte ghost membranes causes protein and lipid immobilization and cholesterol depletion

1988 • 29 citations

Evidence for secretion of human eosinophil granule major basic protein and Charcot-Leyden crystal protein during eosinophil maturation.

1984 • 27 citations

The gene for human eosinophil Charcot-Leyden crystal protein directs expression of lysophospholipase activity and spontaneous crystallization in transiently transfected COS cells

1992 • 26 citations

Charcot-Leyden crystal protein in the degranulation and recovery of activated basophils

1992 • 21 citations

Isolation and characterization of three lysophospholipases from the murine macrophage cell line WEHI 265.1

1992 • 19 citations

Comparison of six mammalian lysophospholipases.

1993 • 14 citations

Biological and physiopathological ideas on eosinophilia. Observations on the nature of Charcot-Leyden crystals.

1962 • 5 citations

Effects of anti-thymocyte serum on the eosinophil and lysophospholipase responses in mice infected withTrichinella spiralis

1987 • 4 citations

Site-directed Mutagenesis at CYS<sup>29</sup> and CYS<sup>57</sup> enhances the enzyme activity of human Eosinophil Lysophospholipase

1993 • 2 citations

S8.19 Secretion of the baby hamster kidney carbohydrate-binding protein 30 KDA (CBP30) from polarized and non-polarized cells

1993 • 1 citations