Modulation of 5-fluorouracil toxicity by allopurinol in man

An Analytical System for Rapid Separation of Tissue Nucleotides at Low Pressures on Conventional Anion Exchangers

1975 • 534 citations

A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil.

1978 • 516 citations

Colony Formation by Normal and Leukemic Human Marrow Cells in Culture: Effect of Conditioned Medium From Human Leukocytes

1971 • 490 citations

Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma

1975 • 420 citations

Neurotoxicity of Commonly Used Antineoplastic Agents

1974 • 403 citations

Clinical Pharmacokinetics

1975 • 298 citations

Fluorinated Pyrimidines

1965 • 252 citations

Phase I and pharmacological studies of 5-fluorouracil administered intraperitoneally.

1980 • 249 citations

Thymidylate synthetase: Mechanism of inhibition by 5-fluoro-2′-deoxyuridylate

1972 • 197 citations

The Clinical Pharmacology of Antineoplastic Agents

1975 • 181 citations

Effects of a xanthine oxidase inhibitor on thiopurine metabolism, hyperuricemia and gout

2001 • 158 citations

Allopurinol: Alteration in Pyrimidine Metabolism in Man

1970 • 151 citations

Orotidinuria Induced by Allopurinol

1970 • 128 citations

Studies on Fluorinated Pyrimidines XVI. Metabolism of 5-Fluorouracil-2-C14 and 5-Fluoro-2′-deoxyuridine-2-C14 in Cancer Patients

1963 • 126 citations

Simultaneous liquid chromatography of 5-fluorouracil, uridine, hypoxanthine, xanthine, uric acid, allopurinol, and oxipurinol in plasma.

1980 • 122 citations

Pharmacokinetics of fluorouracil in humans.

1978 • 118 citations

The Incorporation of 5-Fluorouracil Into RNA and its Molecular Consequences

1969 • 117 citations

The Clinical Pharmacology of Antineoplastic Agents

1975 • 117 citations

RELATIONSHIP BETWEEN METABOLIC FATES AND ANTITUMOR ACTIVITIES OF THIOPURINES.

1963 • 113 citations

Fluorouracil Therapy in Patients With Carcinoma of the Large Bowel

1978 • 107 citations

Clinical response and plasma levels of 5-fluorouracil in patients with colonic cancer treated by drug infusion

1978 • 105 citations

Studies on the coordinate activity and lability of orotidylate phosphoribosyltransferase and decarboxylase in human erythrocytes, and the effects of allopurinol administration

1971 • 104 citations

Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5-phosphate decarboxylase.

1975 • 104 citations

Kinetic Properties and Inhibition of Orotidine 5′-Phosphate Decarboxylase

1973 • 83 citations

Clinical pharmacology of oral and intravenous 5-fluorouracil (NSC-19893).

1974 • 73 citations

Comparison of pharmacokinetics of 5-fluorouracil and 5-fluorouracil with concurrent thymidine infusions in a Phase I trial.

1980 • 73 citations

Effect of 5-fluorouracil on the synthesis and translation of polyadenylic acid-containing RNA from regenerating rat liver.

1979 • 60 citations

Determination of 5-fluorouracil (NSC-19893) plasma levels in rats and man by isotope dilution-mass fragmentography.

1975 • 46 citations

Selective antagonism of 5-fluorouracil cytotoxicity by 4-hydroxypyrazolopyrimidine (allopurinol) in vitro.

1979 • 44 citations

Allopurinol modification of the toxicity and antitumor activity of 5-fluorouracil.

1980 • 36 citations

Disposition of 5-fluorouracil after intravenous bolus doses of a commercial formulation to cancer patients.

1977 • 32 citations

Inhibition of human erythrocyte orotidylate decarboxylase

1977 • 26 citations

Allopurinol modulation of high-dose fluorouracil toxicity

1979 • 24 citations

In vitro growth and drug sensitivity of tumor colony-forming units from human tumor xenografts.

1981 • 16 citations

The effect of prednisolone and other factors on the catabolism of 5-fluorouracil in rats.

1971 • 14 citations

Effects of Allopurinol and Oxipurinol on Pyrimidine Biosynthesis in Man

1974 • 7 citations