The GABAa receptor-gated ion channel: Biochemical and pharmacological studies of structure and function

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.

1987 • 1,166 citations

Receptors for the Age of Anxiety: Pharmacology of the Benzodiazepines

1980 • 866 citations

Structural homology of Torpedo californica acetylcholine receptor subunits

1983 • 798 citations

The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors

1987 • 730 citations

DRUG INTERACTIONS AT THE GABA RECEPTOR-IONOPHORE COMPLEX

1982 • 696 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

The action of γ-Aminobutyric acid on cortical neurones

1967 • 612 citations

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.

1987 • 601 citations

Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons.

1981 • 559 citations

[35S]t-butylbicyclophosphorothionate binds with high affinity to brain-specific sites coupled to gamma-aminobutyric acid-A and ion recognition sites.

1983 • 544 citations

Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes.

1986 • 543 citations

Non-competitive antagonists of excitatory amino acid receptors

1987 • 502 citations

Modulation of the GABA receptor complex by a steroid anaesthetic

1984 • 496 citations

Activation of multiple-conductance state chloride channels in spinal neurones by glycine and GABA

1983 • 402 citations

A gamma-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex.

1983 • 368 citations

Benzodiazepine/GABA Receptors and Chloride Channels: Structural and Functional Properties.

1987 • 368 citations

Drug blockade of open end‐plate channels.

1976 • 352 citations

Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in brain?

1987 • 329 citations

Molecular heterogeneity of benzodiazepine receptors

1980 • 329 citations

Co-localization of GABAA receptors and benzodiazepine receptors in the brain shown by monoclonal antibodies

1985 • 317 citations

Steroid hormone metabolites potentiate GABA receptor-mediated chloride ion flux with nanomolar potency

1987 • 288 citations

Gamma-aminobutyric acid and alcohol actions: Neurochemical studies of long sleep and short sleep mice

1986 • 280 citations

Chlordiazepoxide selectively augments GABA action in spinal cord cell cultures

1977 • 280 citations

Benzodiazepine receptor protein identified and visualized in brain tissue by a photoaffinity label.

1980 • 275 citations

Role of acetylcholine receptor subunits in gating of the channel

1985 • 272 citations

Functional Coupling of γ-Aminobutyric Acid Receptors to Chloride Channels in Brain Membranes

1985 • 270 citations

Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from Torpedo marmorata

1983 • 250 citations

Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator.

1986 • 229 citations

A gamma-aminobutyric acid/benzodiazepine receptor complex from bovine cerebral cortex. Improved purification with preservation of regulatory sites and their interactions.

1984 • 208 citations

Molecular studies of the neuronal nicotinic acetylcholine receptor family

1987 • 203 citations

Different Actions of Anticonvulsant and Anesthetic Barbiturates Revealed by Use of Cultured Mammalian Neurons

1978 • 175 citations

Separate subunits for agonist and benzodiazepine binding in the gamma-aminobutyric acidA receptor oligomer.

1986 • 168 citations

Ethanol enhances GABA-induced 36Cl-influx in primary spinal cord cultured neurons

1986 • 168 citations

Binding Characteristics and Interactions of Depressant Drugs with [³⁵S]t-Butylbicyclophosphorothionate, a Ligand that Binds to the Picrotoxinin Site

1984 • 156 citations

gamma-Aminobutyric acid (GABA)- and barbiturate-mediated 36Cl- uptake in rat brain synaptoneurosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel.

1986 • 151 citations

A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons

1987 • 144 citations

Effects of insecticides on GABA‐induced chloride influx into rat brain microsacs

1986 • 131 citations

Perspectives

1976 • 129 citations

Neurotoxic insecticides inhibit GABA-dependent chloride uptake by mouse brain vesicles

1985 • 106 citations

gamma-Aminobutyric acid and benzodiazepine receptors: copurification and characterization.

1981 • 105 citations

The GABAA/benzodiazepine receptor is a heterotetramer of homologous alpha and beta subunits.

1987 • 101 citations

Barbiturates, alcohols and the CNS excitatory neurotransmission: Specific effects on the kainate and quisqualate receptors

1984 • 98 citations

[3H]Muscimol photolabels the γ-aminobutyric acid receptor binding site on a peptide subunit distinct from that labeled with benzodiazepines

1986 • 96 citations

Characterization of photoaffinity labeling of benzodiazepine binding sites.

1981 • 95 citations

Characterization of barbiturate-stimulated chloride efflux from rat brain synaptoneurosomes

1985 • 94 citations

γ-Aminobutyric acid activation of36Cl-flux in rat hippocampal slices and its potentiation by barbiturates

1984 • 94 citations

Isolation of Putative Benzodiazepine Receptors from Rat Brain Membranes by Affinity Chromatography

1982 • 93 citations

gamma-Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes.

1986 • 89 citations

The effect of benzodiazepines and β-carbolines on gabastimulated chloride influx by membrane vesicles from the rat cerebral cortex

1986 • 86 citations

Benzodiazepine Enhancement of γ‐Aminobutyric Acid‐Mediated Chloride Ion Flux in Rat Brain Synaptoneurosomes

1988 • 86 citations

The Benzodiazepine/GABA Receptor Complex: Molecular Size in Brain Synaptic Membranes and in Solution

1982 • 83 citations

Neurochemical actions of anesthetic drugs on the gamma-aminobutyric acid receptor-chloride channel complex.

1987 • 83 citations

Barbiturate and picrotoxin‐sensitive chloride efflux in rat cerebral cortical synaptoneurosomes

1984 • 80 citations

Modulation of the Benzodiazepine/γ‐Aminobutyric Acid Receptor Chloride Channel Complex by Inhalation Anesthetics

1988 • 79 citations

Anesthetic and convulsant barbiturates alter gamma-aminobutyric acid-stimulated chloride flux across brain membranes.

1986 • 77 citations

Radiation inactivation of brain [35S]t-butylbicyclophosphorothionate binding sites reveals complicated molecular arrangements of the GABA/benzodiazepine receptor chloride channel complex

1985 • 76 citations

gamma-Aminobutyric acid-gated chloride channels in cultured cerebral neurons.

1984 • 74 citations

Subunit structure of the acetylcholine receptor from Electrophorus electricus.

1982 • 63 citations

Purification of γ-aminobutyric acid (GABA) receptor from rat brain by affinity column chromatography using a new benzodiazepine, 1012-S, as an immobilized ligand

1984 • 60 citations

Purified benzodiazepine receptor retains modulation by GABA

1983 • 53 citations

In situ molecular weight determination of brain and peripheral benzodiazepine binding sites

1981 • 52 citations

Neurology and Neurobiology

1985 • 52 citations

Regional difference in brain benzodiazepine receptor carbohydrates.

1986 • 48 citations

Antibodies Recognising the GABA_A/Benzodiazepine Receptor Including Its Regulatory Sites

1986 • 47 citations

Inhibition of the GABA receptor-gated chloride ion channel in brain by noncompetitive inhibitors of the nicotinic receptor-gated cation channel.

1988 • 40 citations

Binding of GABA receptor channel drugs to a putative voltage-dependent chloride channel in torpedo electric organ

1985 • 35 citations

Characterization of GAVAA receptor-mediated 36chloride uptake in rat brain synaptoneurosomes

1987 • 34 citations

Photoaffinity Labeling of the GABA_A Receptor with [³H]Muscimol

1985 • 33 citations

gamma-Aminobutyric acid receptor-regulated 36Cl- flux in mouse cortical slices.

1987 • 32 citations

Benzodiazepine and β-carboline modulation of GABA-stimulated 36Cl-influx in cultured spinal cord neurons

1987 • 29 citations

Comparison of the molecular structure of GABA/benzodiazepine receptors purified from rat and human cerebellum

1987 • 27 citations

Molecular sizes of photolabeled GABA and benzodiazepine receptor proteins are identical

1983 • 26 citations

A structural and dynamic model for the nicotinic acetylcholine receptor

1987 • 24 citations

Radiation Inactivation Studies of the Benzodiazepine/γ‐Aminobutyric Acid/Chloride Ionophore Receptor Complex

1985 • 23 citations

Neurobiology of phencyclidine--an update.

1978 • 22 citations

Neurotransmitter receptors. Mechanisms of action and regulation

1986 • 20 citations

Biochemical Properties of the GABA/Barbiturate/Benzodiazepine Receptor-Chloride Ion Channel Complex

1984 • 18 citations

The molecular target size of brain TBPS binding sites

1983 • 18 citations

A partial structure for the γ‐aminobutyric acid (GABA_A) receptor is derived from the model for the nicotinic acetylcholine receptor The anion‐exchange protein of cell membranes is related to the GABA_A receptor

1988 • 14 citations

GABAA receptor-controlled 36Cl− influx in cultured rat cerebellar granule cells

1987 • 12 citations

Benzomorphan interactions with acetylcholine receptor complexes from Torpedo

1983 • 6 citations