Murine Leukemia Viruses with Recombinant env Genes: A Discussion of Their Role in Leukemogenesis

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

CELL-FREE TRANSMISSION IN ADULT SWISS MICE OF A DISEASE HAVING THE CHARACTER OF A LEUKEMIA

1957 • 759 citations

A new class of murine leukemia virus associated with development of spontaneous lymphomas.

1977 • 718 citations

Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus.

1976 • 491 citations

Genetic Control Of Murine Viral Leukemogenesis

1973 • 452 citations

"Spontaneous" Leukemia Developing in G3H Mice Following Inoculation, In Infancy, with AK-Emkemic.

1951 • 371 citations

Biochemical evidence that MCF murine leukemia viruses are envelope (env) gene recombinants.

1977 • 354 citations

"Spontaneous" leukemia developing in C3H mice following inoculation in infancy, with AK-leukemic extracts, or AK-embrvos.

1951 • 335 citations

On the natural history of the murine leukemias: presidential address.

1967 • 330 citations

Lymphomagenicity of recombinant mink cell focus-inducing murine leukemia viruses.

1980 • 316 citations

The detection and study of tumor viruses with the electron microscope.

1960 • 298 citations

Assay for friend leukemia virus: Rapid quantitative method based on enumeration of macroscopic spleen foci in mice

1964 • 297 citations

Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas

1982 • 289 citations

THE GIX SYSTEM

1971 • 261 citations

Expression of leukemogenic recombinant viruses associated with a recessive gene in HRS/J mice.

1980 • 242 citations

QUANTITATIVE STUDIES OF NATURALLY OCCURRING MURINE LEUKEMIA VIRUS INFECTION OF AKR MICE

1972 • 239 citations

Isolation of Naturally Occurring Viruses of the Murine Leukemia Virus Group in Tissue Culture

1969 • 214 citations

Transfection of molecularly cloned Friend murine leukemia virus DNA yields a highly leukemogenic helper-independent type C virus

1980 • 212 citations

Origin of mink cytopathic focus-forming (MCF) viruses:Comparison with ecotropic and xenotropic murine leukemia virus genomes

1981 • 206 citations

Characterization and mapping of RNase T1-resistant oligonucleotides derived from the genomes of Akv and MCF murine leukemia viruses.

1978 • 204 citations

A novel murine oncornavirus with dual eco- and xenotropic properties.

1975 • 201 citations

Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal.

1975 • 198 citations

Molecular Biology of RNA Tumor Viruses

1980 • 194 citations

AKR leukemogenesis: Identification and biological significance of thymic lymphoma receptors for AKR retroviruses

1979 • 181 citations

IMMUNOGENETICS OF CELL SURFACE ANTIGENS OF MOUSE LEUKEMIA

1977 • 174 citations

Biochemical evidence linking the GIX thymocyte surface antigen to the gp69/71 envelope glycoprotein of murine leukemia virus.

1975 • 155 citations

Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice.

1976 • 153 citations

Interference grouping of murine leukemia viruses: A distinct receptor for the MCF-Recombinant viruses in mouse cells

1982 • 151 citations

Friend murine leukemia virus-induced leukemia is associated with the formation of mink cell focus-inducing viruses and is blocked in mice expressing endogenous mink cell focus-inducing xenotropic viral envelope genes.

1981 • 149 citations

Development and Serial Cell-Free Passage of a Highly Potent Strain of Mouse Leukemia Virus.

1957 • 148 citations

Correlation of early murine leukemia virus titer and H-2 type with spontaneous leukemia in mice of the BALB/c times AKR cross: a genetic analysis.

1975 • 144 citations

Friend strain of spleen focus-forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus

1977 • 140 citations

Genetic factors in the natural history of murine leukemia virus infection: G. H. A. Clowes Memorial Lecture.

1973 • 137 citations

Characterization of a protein found in cells infected with the spleen focus-forming virus that shares immunological cross-reactivity with the gp70 found in mink cell focus-inducing virus particles

1979 • 136 citations

The Fv-1 Gene of the Mouse and its Control of Murine Leukemia Virus Replication

1979 • 132 citations

Relation of GIX antigen of thymocytes to envelope glycoprotein of murine leukemia virus.

1975 • 127 citations

Friend strain of spleen focus-forming virus is a recombinant between ecotropic murine type C virus and the env gene region of xenotropic type C virus.

1977 • 126 citations

Spleen Focus-Forming Virus in Friend and Rauscher Leukemia Virus Preparations2

1975 • 125 citations

Erythropoietin‐independent erythroid colony formation in vitro by hemopoietic cells of mice infected with friend virus

1975 • 120 citations

Oncogenicity of AKR endogenous leukemia viruses

1978 • 119 citations

Rapid leukemia induced by cloned Friend strain of replicating murine type-C virus Association with induction of xenotropic-related RNA sequences contained in spleen focus-forming virus

1978 • 119 citations

Experimental Studies on Lymphomatosis of Mice

1933 • 117 citations

Polycythemia- and anemia-inducing erythroleukemia viruses exhibit differential erythroid transforming effects in vitro

1980 • 113 citations

Envelope gene sequences which encode the gp52 protein of spleen focus-forming virus are required for the induction of erythroid cell proliferation

1982 • 108 citations

Glycoprotein encoded by the Friend spleen focus-forming virus

1979 • 104 citations

Leukemogenic properties of AKR dualtropic (MCF) viruses: Amplification of murine leukemia virus-related antigens on thymocytes and acceleration of leukemia development in AKR mice

1981 • 103 citations

The effect of helper virus on Abelson virus-induced transformation of lymphoid cells.

1978 • 102 citations

Novel leukaemogenic retroviruses isolated from cell line derived from spontaneous AKR tumour

1981 • 100 citations

M-MuLV-induced leukemogenesis: Integration and structure of recombinant proviruses in tumors

1981 • 97 citations

Large RNase T1-resistant oligonucleotides encoding p15E and the U3 region of the long terminal repeat distinguish two biological classes of mink cell focus-forming type C viruses of inbred mice

1983 • 96 citations

Structure of the murine leukemia virus envelope glycoprotein precursor

1979 • 91 citations

Structural domains of endogenous murine leukemia virus gp70s containing specific antigenic determinants defined by monoclonal antibodies

1982 • 91 citations

B-tropic friend virus: A host-range pseudotype of spleen focus-forming virus (SFFV)

1973 • 91 citations

Isolation of a fibroblast nonproducer cell line containing the friend strain of the spleen focus-forming virus

1977 • 90 citations

Characterization of AKR murine leukemia virus sequences in AKR mouse substrains and structure of integrated recombinant genomes in tumor tissues

1981 • 90 citations

Helper-independent mink cell focus-inducing strains of Friend murine type-C virus: potential relationship to the origin of replication-defective spleen focus-forming virus.

1978 • 89 citations

Properties of “mink cell focus-inducing” (MCF) virus isolated from spontaneous lymphoma lines of BALB/c mice carrying moloney leukemia virus as an endogenous virus

1979 • 86 citations

Heteroduplex analysis of the sequence relations between the RNAs of mink cell focus-inducing and murine leukemia viruses

1978 • 85 citations

Prevalence of the group‐specific (gs) antigen and infectious virus expressions of the murine C‐type RNA viruses during the life span of BALB/cCr mice

1972 • 83 citations

Age-related changes in cell surface antigens of preleukemic AKR thymocytes.

1976 • 82 citations

The physiopathology of friend leukemia

1979 • 80 citations

Nucleotide sequence of the 3' end of MCF 247 murine leukemia virus

1983 • 75 citations

Murine leukaemogenesis: monoclonal antibodies to T-cell determinants arrest T-lymphoma cell proliferation

1980 • 75 citations

Chronic immune stimulation is required for Moloney leukaemia virus-induced lymphomas

1981 • 75 citations

Biological activity of the spleen focus-forming virus is encoded by a molecularly cloned subgenomic fragment of spleen focus-forming virus DNA.

1981 • 75 citations

Brief Communication: Friend Leukemia: Rapid Development of Erythropoietin-Independent Hematopoietic Precursors2

1975 • 74 citations

Host-Gene Control of Type-C RNA Tumor Virus Expression and Tumorigenesis in Inbred Mice

1973 • 74 citations

G(AKSL2): a new cell surface antigen of the mouse related to the dualtropic mink cell focus-inducing class of murine leukemia virus detected by naturally occurring antibody.

1979 • 73 citations

Recovery of biologically active spleen focus-forming virus from molecularly cloned spleen focus-forming virus-pBR322 circular DNA by cotransfection with infectious type C retroviral DNA

1980 • 73 citations

The Friend virus genome: Evidence for the stable association of MuLV sequences and sequences involved in erythroleukemic transformation

1977 • 71 citations

Spleen Focus Formation by Polycythemic Strains of Friend Leukemia Virus

1968 • 70 citations

Plasma membrane glycoproteins encoded by cloned Rauscher and Friend spleen focus-forming viruses

1980 • 68 citations

Moloney leukemia virus gene expression and gene amplification in preleukemic and leukemic BALB/Mo mice

1979 • 67 citations

Analysis of the Genomes of Mink Cell Focus-inducing Murine Type-C Viruses: A Progress Report

1980 • 65 citations

Three laboratory strains of spleen focus-forming virus: comparison of their genomes and translational products

1980 • 65 citations

Isolation of transplantable erythroleukemia cells from mice infected with helper-independent Friend murine leukemia virus

1981 • 64 citations

Anemia- and polycythemia-inducing isolates of Friend spleen focus-forming virus. Biological and molecular evidence for two distinct viral genomes.

1980 • 58 citations

Induction of GIX antigen and gross cell surface antigen after infection by ecotropic and xenotropic murine leukemia viruses in vitro

1976 • 57 citations

Genetic study of lymphoma induction by AKR mink cell focus-inducing virus in AKR x NFS crosses.

1981 • 57 citations

Status of the Association of Mink Cell Focus-forming Viruses with Leukemogenesis

1980 • 57 citations

Biological, immunological, and biochemical evidence that HIX virus is a recombinant between moloney leukemia virus and a murine xenotropic C type virus

1978 • 55 citations

Erythroleukemia induction by replication-competent type C viruses cloned from the anemia- and polycythemia-inducing isolates of Friend leukemia virus.

1980 • 55 citations

SUBCELLULAR STRUCTURES OF POSSIBLE VIRAL ORIGIN IN SOME MAMMALIAN TUMORS

1957 • 54 citations

Simian virus 40 induces the production of a polypeptide transforming factor(s)

1981 • 54 citations

Rauscher “mink cell focus-inducing” (MCF) virus causes erythroleukemia in mice: Its isolation and properties

1980 • 54 citations

Helper-independent and replication-defective erythroblastosis-inducing viruses contained within anemia-inducing friend virus complex (FV-A)

1980 • 53 citations

Cell-surface antigens associated with recombinant mink cell focus-inducing murine leukemia viruses.

1979 • 52 citations

Selective expression of xenotropic virus in congenic HRS/J (hairless) mice

1977 • 52 citations

Heterogeneous metabolism and subcellular localization of a potentially leukemogenic membrane glycoprotein encoded by Friend erythroleukemia virus. Isolation of viral and cellular processing mutants.

1982 • 52 citations

Differences in glycosylation patterns of closely related murine leukemia viruses

1980 • 51 citations

Polycythaemia- and anaemia-inducing strains of spleen focus-forming virus differ in post-translational processing of envelope-related glycoproteins

1981 • 51 citations

Properties of mouse leukemia viruses XVI. Suppression of spontaneous fatal leukemias in AKR mice by treatment with broadly reacting antibody against the viral glycoprotein gp 71

1979 • 51 citations

Rapid emergence of mink cell focus-forming (MCF) virus in various mice infected with NB-tropic friend virus

1981 • 51 citations

Prevention of spontaneous leukemia in AKR mice by type-specific immunosuppression of endogenous ecotropic virogenes.

1976 • 49 citations

Molecular cloning of a highly leukemogenic, ecotropic retrovirus from an AKR mouse

1982 • 49 citations

Conformation of free and of integrated Moloney leukemia virus proviral DNA in preleukemic and leukemic BALB/Mo mice

1980 • 49 citations

Heteroduplex analysis of the nonhomology region between Moloney MuLV and the dual host range derivative HIX virus

1978 • 48 citations

Viral protein synthesis in Friend erythroleukemia cell lines

1977 • 46 citations

Expression of murine leukemia viruses in the highly lymphomatous BXH-2 recombinant inbred mouse strain

1981 • 46 citations

Spleen focus-forming Friend virus: identification of genomic RNA and its relationship to helper virus RNA

1979 • 45 citations

The Role of MuLV Receptors on T-Lymphoma Cells in Lymphoma Cell Proliferation

1980 • 44 citations

Synthesis and processing of viral proteins in Friend erythroleukemia cell lines

1978 • 43 citations

Cell surface expression of the env gene polyprotein of dual-tropic mink cell focus-forming murine leukemia virus

1979 • 43 citations

Cellular changes in the thymuses of preleukemic AKR mice: Correlation with changes in the expression of murine leukemia viruses

1977 • 42 citations

Immunoselection of mutants deficient in cell surface glycoproteins encoded by murine erythroleukemia viruses.

1980 • 42 citations

Different lymphoid cell targets for transformation by replication-competent moloney and rauscher mouse leukemia viruses

1980 • 42 citations

Generation of oncogenic type C viruses: Rapidly leukemogenic viruses derived from C3H mouse cells in vivo and in vitro

1978 • 41 citations

Fv-1 Regulation of lymphoma development and of thymic, ecotropic and xenotropic muLV expression in mice of the AKR/J × RF/J Cross

1978 • 40 citations

Binding characteristics of Rauscher leukemia virus envelope glycoprotein gp71 to murine lymphoid cells

1977 • 40 citations

Molecular dissection of Rauscher virus gp70 by using monoclonal antibodies: localization of acquired sequences of related envelope gene recombinants.

1980 • 39 citations

Analysis of the expression of spleen focus-forming virus (SFFV)-related RNA and gp55, a friend and rauscher virus-specific protein

1980 • 39 citations

Mapping host range-specific oligonucleotides within genomes of the ecotropic and mink cell focus-inducing strains of Moloney murine leukemia virus

1978 • 39 citations

Wild mouse ecotropic murine leukemia virus infection of inbred mice: dual-tropic virus expression precedes the onset of paralysis and lymphoma

1981 • 39 citations

Retrovirus Lymphomagenesis: Relationship of Normal Immune Receptors to Malignant Cell Proliferation

1982 • 39 citations

Passive immunotherapy prevents expression of endogenous Moloney virus and amplification of proviral DNA in BALB/Mo mice.

1980 • 36 citations

Properties of mouse leukemia viruses XIV. Prevention of spontaneous akr leukemia by treatment with group-specific antibody against the major virus gp71 glycoprotein

1977 • 36 citations

Analysis of translational products of Friend strain of spleen focus-forming virus

1978 • 35 citations

RNAs of Defective and Nondefective Components of Friend Anemia and Polycythemia Virus Strains Identified and Compared

1980 • 34 citations

Leukemogenicity of Clonal Isolates of Murine Leukemia Viruses 2

1978 • 32 citations

Mechanisms of C-type viral leukemogenesis. I. Correlation of in vitro lymphocyte blastogenesis to viremia and leukemia.

1979 • 32 citations

Most sequence differences between the genomes of the Akv virus and a leukemogenic Gross A virus passaged in vitro are located near the 3' terminus.

1980 • 31 citations

Murine-leukemia-virus-related Cell-surface Antigens as Serological Markers of AKR Ecotropic, Xenotropic, and Dualtropic Viruses

1980 • 31 citations

Rapid assay of murine leukemia virus helper activity for Friend spleen focus-forming virus.

1971 • 30 citations

Serological analysis of antigenic determinants on the env gene oroducts of AKR dualtropic (MCF) murine leukemia viruses

1980 • 29 citations

Large T1 oligonucleotides of Moloney leukemia virus missing in an env gene recombinant, HIX, are present on an intracellular 21S Moloney viral RNA species.

1978 • 29 citations

Acquisition of oncogenicity by endogenous mouse type C viruses: effects of variations in env and gag genes

1978 • 29 citations

Genetic and viral factors influencing the development of spontaneous leukemia in AKR mice

1979 • 29 citations

Genome organization of retroviruses. VI. Heteroduplex analysis of ecotropic and xenotropic sequences of moloney mink cell focus-inducing viral RNA obtained from either a cloned isolate or a thymoma cell line

1979 • 28 citations

Increased responses to lymphokines are correlated with preleukemia in mice inoculated with Moloney leukemia virus.

1981 • 27 citations

Genome organization of retroviruses IX. Analysis of the genomes of friend spleen focus-forming (F-SFFV) and helper murine leukemia viruses by heteroduplex-formation

1980 • 27 citations

Defectivity of Rauscher Murine Erythroblastosis Virus

1972 • 25 citations

Genomic Masking and Rescue of Dual-Tropic Murine Leukemia Viruses: Role of Pseudotype Virions in Viral Lymphomagenesis

1980 • 25 citations

Structure of retroviral RNAs produced by cell lines derived from spontaneous lymphomas of AKR mice

1982 • 24 citations

Characterization of virus produced by a lymphoma induced by inoculation of AKR MCF-247 virus

1980 • 24 citations

The R.I.L. Strain of Mice: Its Relation to the Leukemic AK Strain and AKR Substrains

1954 • 23 citations

Cell surface receptors for ecotropic MULV: Detection and tissue distribution of free receptors in vivo

1978 • 23 citations

Possible Immunological Mechanisms in C-Type Viral Leukemogenesis in Mice

1982 • 22 citations

In vitro expression of erythroid differentiation induced by Friend polycythaemia virus

1975 • 22 citations

Leukemogenesis by Gross passage A murine leukemia virus: expression of viruses with recombinant env genes in transformed cells.

1982 • 21 citations

A cell surface antigen of the mouse related to xenotropic MuLv defined by naturally occurring antibody and monoclonal antibody. Relation to Gix G(rada1), G(aksl2) systems of MuLV-related antigens.

1981 • 21 citations

Subcellular localization of the env-related glycoproteins in Friend erythroleukemia cells

1981 • 20 citations

Glycopeptides of Murine Leukemia Viruses I. Comparison of Two Ecotropic Viruses

1979 • 19 citations

Control of Proliferation and Differentiation in Cells Transformed by Friend Virus

1980 • 19 citations

Viral protein expression in producer and nonproducer clones of friend erythroleukemia cell lines

1981 • 19 citations

Acceleration of leukemogenesis in akr mice by grafts, cell suspensions, and cell‐free centrifugates of thymuses from preleukemic akr donors

1968 • 18 citations

In vivo and in vitro recovery of defective friend virus by various leukemia viruses

1971 • 18 citations

Glycopeptides of murine leukemia viruses. II. Comparison of xenotropic and dual-tropic viruses

1980 • 17 citations

The env-gene of the spleen focus-forming virus lacks expression of p15(E) determinants

1980 • 17 citations

Env gene products of AKR dual-tropic viruses: examination of peptide maps and cell surface expression

1981 • 16 citations

Leukemogenic activity of murine type C viruses after long-term passagein vitro

1976 • 15 citations

Role of endogenous murine leukemia virus in immunologically triggered lymphoreticular tumors II. Isolation of B-tropic mink cell focus-inducing (MCF) murine leukemia virus

1980 • 15 citations

Properties of mouse leukemia viruses XVII. Factors required for successful treatment of spontaneous AKR leukemia by antibodies against gp71

1981 • 14 citations

Murine Leukemia Virus env-gene Expression in Preleukemic Thymocytes and Leukemia Cells of AKR Strain Mice

1980 • 14 citations

Glycopeptides of Murine Leukemia Viruses III. Glycosylation of env Precursor Glycoproteins

1981 • 14 citations

Amplified env and gag products on AKR cells. Origin from different murine leukemia virus genomes.

1980 • 12 citations

Amplified expression of murine leukemia virus (MuLV)-coded antigens on thymocytes and leukemia cells of AKR mice after infection by dualtropic (MCF) MuLV

1982 • 10 citations

T1 oligonucleotide maps of moloney and HIX murine leukemia viruses

1978 • 10 citations

Role of Endogenous Murine Leukemia Virus in Immunologically Triggered Lymphoreticular Tumors. I. Development and Use of Oncogenic Cellfree Preparations Serially Passaged In Vivo2

1977 • 6 citations

Leukemogenicity and cell transformation mechanisms in vitro by Gross murine leukemia virus: analysis of virus subpopulations

1981 • 5 citations

Too Many Airlines

1972 • 5 citations

Influence of Fv-1 alleles on cellular expression of gp70.

1980 • 4 citations

Accelerated development of strain ak/n mouse lymphomas by cell-free tissue and tumor extracts. Abstr.

1962 • 4 citations

Relative loss of oncogenic potency of mouse leukemia virus (Gross) after prolonged propagation in tissue culture.

1978 • 4 citations