NSAIDs, Cox-2 inhibitors, and the gut

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

1994 • 1,322 citations

Risk of upper gastrointestinal bleeding and perforation associated with Individual non-steroidal anti-inflammatory drugs

1994 • 981 citations

Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs

1994 • 881 citations

Nonsteroidal Anti-inflammatory Drug Use and Increased Risk for Peptic Ulcer Disease in Elderly Persons

1991 • 783 citations

Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases.

1994 • 500 citations

Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.

1994 • 462 citations

Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

1994 • 339 citations

Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs

1991 • 327 citations

Review: The Biochemical Basis of Non-Steroidal Anti-Inflammatory Drug-Induced Damage to the Gastrointestinal Tract: A Review and a Hypothesis

1995 • 182 citations

Variation in the risk of peptic ulcer complications with nonsteroidal antiinflammatory drug therapy

1993 • 130 citations

Aspirin and Other Salicylates

1993 • 105 citations

Safety experience with nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis

1993 • 49 citations

Nonsteroidal anti-inflammatory drugs : mechanisms and clinical use

1987 • 46 citations

Pulmonary-Allergy, Dermatological, Gastrointestinal and Arthritis: Cyclooxygenase-2: a novel target for therapeutic intervention

1994 • 16 citations