Kinetics and Steady State Dynamics of Tubulin Addition and Loss at Opposite Microtubule Ends: The Mechanism of Action of Colchicinea

Dynamic instability of microtubule growth

1984 • 3,187 citations

Microtubule assembly nucleated by isolated centrosomes

1984 • 775 citations

Head to tail polymerization of actin

1976 • 692 citations

Thermodynamics of the Polymerization of Protein

1976 • 580 citations

Opposite end assembly and disassembly of microtubules at steady state in vitro

1978 • 567 citations

Tubulin-nucleotide interactions during the polymerization and depolymerization of microtubules

1976 • 281 citations

Microtubule treadmills—possible molecular machinery

1981 • 279 citations

Head-to-tail polymerization of microtubules in vitro. Electron microscope analysis of seeded assembly.

1980 • 279 citations

Structural polarity of kinetochore microtubules in PtK1 cells.

1981 • 218 citations

Visualization of the structural polarity of microtubules

1980 • 213 citations

Interference of GTP hydrolysis in the mechanism of microtubule assembly: an experimental study.

1984 • 160 citations

Colchicine inhibition of microtubule assembly via copolymer formation.

1979 • 147 citations

Dynein binds to and crossbridges cytoplasmic microtubules.

1979 • 146 citations

Isolation of bovine brain microtubule protein without glycerol: Polymerization kinetics change during purification cycles

1979 • 125 citations

Mechanism of colchicine-dimer addition to microtubule ends: implications for the microtubule polymerization mechanism

1980 • 92 citations

Neurotubule assembly at substoichiometric nucleotide levels using a GTP regenerating system

1977 • 59 citations

A Quantitative Analysis of Tubulin-Colchicine Binding to Microtubules

1980 • 55 citations

Tubulin-colchicine complexes differentially poison opposite microtubule ends

1984 • 55 citations

Incorporation of radioactive tubulin into microtubules at steady state. Experimental and theoretical analyses of diffusional and directional flux.

1980 • 51 citations

Kinetic and steady-state analysis of microtubules in the presence of colchicine

1981 • 48 citations

A microtubule assembly/disassembly model based on drug effects and depolymerization kinetics after rapid dilution.

1979 • 48 citations

Tubulin-colchicine complex inhibits microtubule elongation at both plus and minus ends.

1983 • 41 citations

Dynamics of linear protein polymer disassembly.

1980 • 41 citations

A kinetic analysis of assembly-disassembly at opposite microtubule ends.

1982 • 33 citations

Chapter 10 A Rapid Filtration Assay for Analysis of Microtubule Assembly, Disassembly, and Steady-State Tubulin Flux

1982 • 32 citations

Enhancement of tubulin assembly as monitored by a rapid filtration assay

1978 • 28 citations

On the nonlinear relationship between the initial rates of dilution-induced microtubule disassembly and the initial free subunit concentration.

1983 • 26 citations

Differential radiolabeling of opposite microtubule ends: Methodology, equilibrium exchange-flux analysis, and drug poisoning

1983 • 16 citations