REVIEW ARTICLE: THE POLYCYSTIC OVARY SYNDROME

Amenorrhea associated with bilateral polycystic ovaries

1935 • 2,057 citations

SEX‐HORMONE‐BINDING GLOBULIN

1974 • 1,119 citations

Height and Weight at Menarche and a Hypothesis of Critical Body Weights and Adolescent Events

1970 • 715 citations

Episodic Luteinizing Hormone Secretion in Man PULSE ANALYSIS, CLINICAL INTERPRETATION, PHYSIOLOGIC MECHANISMS

1973 • 715 citations

Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome.

1976 • 607 citations

Long-term Treatment of Galactorrhoea and Hypogonadism with Bromocriptine

1974 • 407 citations

Capacity of the Testosterone-Binding Globulin in Human Plasma and Influence of Specific Binding of Testosterone on Its Metabolic Clearance Rate

1969 • 386 citations

Inappropriate Secretion of Follicle-Stimulating Hormone and Luteinizing Hormone in Polycystic Ovarian Disease

1970 • 384 citations

The Polycystic Ovary. I. Clinical and Histologic Features

1962 • 366 citations

Prolactin and Human Reproduction

1978 • 339 citations

Circulating gonadotropins, estrogens, and androgens in polycystic ovarian disease

1975 • 339 citations

A SYNDROME CHARACTERIZED BY PRIMARY OVARIAN INSUFFICIENCY AND DECREASED STATURE

1942 • 330 citations

Adrenarche: A Survey of Rodents, Domestic Animals, and Primates

1978 • 324 citations

Aromatization of Androgens by Human Abdominal and Breast Fat Tissue1

1975 • 311 citations

Evidence for a Role of Androgens in Follicular Maturation

1975 • 283 citations

Clinical and Biochemical Features of Polycystic Ovarian Disease

1963 • 281 citations

Functional Studies of Aromatase Activity in Human Granulosa Cells from Normal and Polycystic Ovaries*

1979 • 250 citations

Regulation of Human Hair Growth by Steroid Hormones. II. Androstenedione Metabolism in Isolated Hairs

1974 • 238 citations

SYNDROME CHARACTERIZED BY GALACTORRHEA, AMENORRHEA AND LOW URINARY FSH: COMPARISON WITH ACROMEGALY AND NORMAL LACTATION*†

1954 • 225 citations

Glucocorticoid inhibition of fsh-induced estrogen production in cultured rat granulosa cells

1978 • 218 citations

Hereditary factors in the Stein-Leventhal syndrome

1968 • 212 citations

Combined Ovarian and Adrenal Vein Catheterization To Determine the Site(s) of Androgen Overproduction in Hirsute Women¹

1971 • 210 citations

Plasma Adrenal and Gonadal Sex Steroids in Human Pubertal Development

1976 • 204 citations

The endocrine function of the human ovary

1977 • 201 citations

Hormonal Changes in Puberty III: Correlation of Plasma Dehydroepiandrosterone,Testosterone, FSH, and LH with Stages of Puberty and Bone Age in Normal Boys and Girls and in Patients with Addison's Disease or Hypogonadism or with Premature or Late Adrenarche

1975 • 200 citations

Regulation of Human Hair Growth by Steroid Hormones. I. Testosterone Metabolism in Isolated Hairs

1974 • 198 citations

The Endocrine function of the human adrenal cortex

1978 • 189 citations

Pituitary-Ovarian Relationships in Polycystic Ovary Syndrome

1977 • 177 citations

Adrenal Function in Normal Women and Women with the Poly cystic Ovary Syndrome*

1979 • 172 citations

Idiopathic Hirsutism — An Ovarian Abnormality

1976 • 168 citations

Glucocorticoid treatment of girls with congenital adrenal hyperplasia: Effects on height, sexual maturation, and fertility

1977 • 168 citations

The Source of Plasma Dihydrotestosterone in Man

1971 • 167 citations

Circulating Concentrations of Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate During Puberty

1975 • 155 citations

The Operating Characteristics of the Hypothalamic–Pituitary System during the Menstrual Cycle and Observations of Biological Action of Somatostatin

1975 • 151 citations

Effects of Induced Hyperthyroidism on Steroid Metabolism in Man

1971 • 138 citations

17β-Estradiol Biosynthesis in Cultured Granulosa and Thecal Cells of Human Ovarian Follicles: Stimulation by Follicle-Stimulating Hormone*

1978 • 138 citations

Aromatization of Androstenedione by Isolated Human Hairs

1975 • 135 citations

Plasma Progesterone and 17-hydroxyprogesterone in normal men and children with congenital adrenal hyperplasia

1969 • 133 citations

Adrenal Function in Hirsutism I. Diurnal Change and Response of Plasma Androstenedione, Testosterone, 17-Hydroxyprogesterone, Cortisol, LH and FSH to Dexamethasone and ½ Unit of ACTH

1975 • 131 citations

Adrenocortical Function in Hyperprolactinemic Women

1977 • 127 citations

Promotion of human adipocyte precursor replication by 17beta-estradiol in culture.

1978 • 126 citations

The Conversion of Androgens to Estrogens in Hyperthyroidism*

1974 • 125 citations

The polycystic ovary

1965 • 123 citations

The metabolic clearance rate and origin of plasma dihydrotestosterone in man and its conversion to the 5α-androstanediols

1971 • 121 citations

Status of Estrogen-Androgen Balance in Hyperthyroid Men with Graves' Disease

1974 • 119 citations

Ovarian Physiology: Relationship Between Plasma LH and Steroidogenesis by the Follicle and Corpus Luteum; Effect of HCG¹

1969 • 118 citations

Defective Biosynthesis of Ovarian Steroids in the Stein-Leventhal Syndrome

1961 • 117 citations

Sleep EEG Stages and Plasma Growth Hormone Concentration in States of Endogenous and Exogenous Hypercortisolemia or ACTH Elevation

1974 • 116 citations

Radioimmunoassay of Plasma 17-Hydroxyprogesterone

1971 • 113 citations

The Effects of Ovarian Wedge Resection on Circulating Gonadotropin and Ovarian Steroid Levels in Patients with Polycystic Ovary Syndrome

1976 • 110 citations

Functional Delineation of Hyperprolactinemic-Amenorrhea¹

1977 • 108 citations

Inhibition of Enzymatic Steroid 11β-Hydroxylation by Androgens

1963 • 100 citations

Plasma Testosterone Profiles in Cushing's Syndrome

1977 • 96 citations

INDUCTION OF OVULATION WITH HUMAN GONADOTROPINS.

1965 • 95 citations

Mean Plasma Concentration, Metabolic Clearance and Basal Plasma Production Rates of Testosterone in Normal Young Men and Women Using a Constant Infusion Procedure: Effect of Time of Day and Plasma Concentration on the Metabolic Clearance Rate of Testosterone

1967 • 94 citations

Effect of Thyroid on Hydroxylation of Estrogen in Man

1965 • 93 citations

Adrenocortical 11β-Hydroxylase Deficiency and Virilism First Manifest in the Adult Woman

1965 • 85 citations

Absence of Nocturnal Elevation of Plasma Prolactin Concentrations in Cushing's Disease

1976 • 82 citations

Effect of Hyperthyroidism and Hypothyroidism on the Metabolism of Testosterone and Androstenedione in Man

1969 • 79 citations

Familial hyperthecosis: Comparison of endocrinologic and histologic findings with polycystic ovarian disease

1973 • 78 citations

Suppression of Testosterone and Androstenedione Production Rates with Dexamethasone in Women with Idiopathic Hirsutism and Polycystic Ovaries

1968 • 78 citations

Polycystic ovarian disease

1965 • 71 citations

The Metabolism of Estrogens in Normal Women After Pulse Injections of³H-Estradiol and³H-Estrone

1974 • 71 citations

MITOGENIC ACTION OF OESTRADIOL-17β ON HUMAN MYOMETRIAL AND ENDOMETRIAL CELLS IN LONG-TERM TISSUE CULTURES

1973 • 69 citations

Hormonal Effects of Wedge Resection of Polycystic Ovaries

1978 • 66 citations

Inhibition of Adrenal Protein Synthesis by Steroidsin Vitro¹

1967 • 65 citations

VIRILISM AND THECA‐CELL HYPERPLASIA OF THE OVARY: A SYNDROME

1949 • 65 citations

STEROID SECRETIONS OF THE NORMAL AND POLYCYSTIC OVARY.

1964 • 65 citations

Androgen Metabolism in the Skin of Hirsute Women¹

1974 • 65 citations

The Use of Gonadotropins for the Induction of Ovulation in Women with Polycystic Ovarian Disease

1977 • 64 citations

Familial ovarian hyperthecosis: A study of two families

1971 • 63 citations

The Effects of Ovariectomy and Estrogen Treatment on the Dopamine Inhibition of Gonadotropin and Prolactin Release*

1979 • 63 citations

Adrenal and Ovarian Contributions to the Elevated Free Plasma Androgen Levels in Hirsute Women

1972 • 62 citations

FURTHER ABNORMALITIES OF THE X CHROMOSOME IN PRIMARY AMENORRH$OElig;A OR IN SEVERE OLIGOMENORRH$OElig;A

1961 • 62 citations

Influence of Thyroid Hormone on Estrogen Metabolism in Man

1962 • 61 citations

An individualized graduated therapeutic regimen for clomiphene citrate

1974 • 60 citations

Gonadotropin Levels and Secretory Patterns in Patients with Typical and Atypical Polycystic Ovarian Disease

1975 • 59 citations

Testosterone-binding globulins in human plasma: studies on sex distribution and specificity

1968 • 59 citations

Endometrial adenocarcinoma and the Stein-Leventhal syndrome.

1978 • 59 citations

Cell-mediated immunity and immune complexes in thyroid disease

1975 • 57 citations

Plasma Androgens in Patients with the Polycystic Ovary Syndrome¹

1968 • 56 citations

Plasma 17-Hydroxyprogesterone, 21-Deoxycortisol and Cortisol in Congenital Adrenal Hyperplasia*

1974 • 55 citations

The Effect of Long Acting Glucocorticoids on Menstrual Abnormalities in Patients with Virilizing Congenital Adrenal Hyperplasia*

1978 • 55 citations

Effect of Clomiphene Citrate in Polycystic Ovary Syndrome: Relationship Between Serum Gonadotropin and Corpus Luteum Function

1970 • 52 citations

Plasma steroids in hirsutism.

1974 • 51 citations

Lack of Correlation Between Gonadotropin and Adrenal Androgen Levels in Agonadal Children

1975 • 50 citations

ENDOMETRIAL CANCER ASSOCIATED WITH FEMINIZING OVARIAN TUMOR AND POLYCYSTIC OVARIAN DISEASE

1977 • 50 citations

Age-Related Response of Plasma Testosterone, Δ⁴-Androstenedione, and Cortisol to Adrenocorticotropin in Infants, Children, and Adults*

1978 • 49 citations

SEX HORMONE LEVELS AND GONADOTROPHIN RELEASE IN THE POLYCYSTIC OVARY SYNDROME

1975 • 49 citations

The Nature of Circulating Estrogen.

1946 • 46 citations

Estrogen-Androgen Imbalance in Patients with Hirsutism and Amenorrhea

1974 • 45 citations

The androgenic ovary, with special reference to the Stein-Leventhal syndrome

1964 • 44 citations

FURTHER OBSERVATIONS ON THE DEFECTIVE SYNTHESIS OF OVARIAN STEROIDS IN THE STEIN-LEVENTHAL SYNDROME

1962 • 43 citations

Effects of Estrogens on Adrenal 3β-Hydroxysteroid Dehydrogenase in Ovariectomized Women

1976 • 42 citations

Correlation of the effects of dexamethasone administration on urinary 17-ketosteroid and serum androgen levels in patients with hirsutism

1977 • 42 citations

Raised serum prolactin levels associated with hirsutism and amenorrhoea.

1975 • 41 citations

Enzymic inadequacies of human polycystic ovaries

1961 • 40 citations

Thecoma and Hyperthecosis of the Ovary

1943 • 40 citations

Studies of the protein binding of dihydrotestosterone (17 β-hydroxy-5 α-androstan-3 one) in human plasma (in different physiological conditions and effect of medroxyprogesterone)

1972 • 39 citations

Congenital adrenal hyperplasia: Age at menarche and related events at puberty

1971 • 38 citations

Studies of the Role of Dopamine in the Control of Prolactin and Gonadotropin Secretion in Humans

1979 • 38 citations

THE ENIGMATIC POLYCYSTIC OVARY

1966 • 37 citations

Plasma Pregnenolone and 17-OH-Pregnenolone in Patients with Adrenal Tumors, ACTH Excess, or Idiopathic Hirsutism1

1977 • 37 citations

ABNORMAL EXCRETION OF PREGNANETRIOLONE AND Δ5-PREGNENETRIOL IN THE STEIN-LEVENTHAL SYNDROME*†

1961 • 35 citations

The origin of androgen and estrogen in a virilized postmenopausal woman with bilateral benign cystic teratomas.

1977 • 34 citations

Early Adrenal Response to ACTH: Plasma Concentrations of Pregnenolone, 17-hydroxypregnenolone, Progesterone, and 17-hydroxyprogesterone

1972 • 34 citations

Growth hormone and the steroid binding β-globulin of human plasma

1972 • 33 citations

Plasma Steroids in Congenital Adrenal Hyperplasia

1974 • 33 citations

PERIPHERAL AND OVARIAN STEROIDS IN OVARIAN HYPERTHECOSIS

1976 • 31 citations

Neuroendocrine Regulation of the Menstrual Cycle

1979 • 30 citations

Multiglandular aspects of the Stein-Leventhal syndrome

1963 • 30 citations

The secretion of androgens by the normal, polycystic and neoplastic ovaries.

1967 • 30 citations

Pituitary-Adrenal Activity in Untreated Congenital Adrenal Hyperplasia

1975 • 26 citations

MODIFICATION BY SEX STEROIDS OF LHRH RESPONSE IN THE POLYCYSTIC OVARY SYNDROME

1976 • 25 citations

Conversion of Testosterone-1,2³H to Androstenedione-³H in the Isolated Hair Follicle of Man

1972 • 24 citations

Estrogen Biosynthesis. III. Stereospecificity of Aromatization by Normal and Diseased Human Ovaries¹

1974 • 23 citations

Ovarian and Adrenal Morphology in Cases of Hirsutism or Virilism and Stein-Leventhal Syndrome

1962 • 23 citations

Features of Turnerʼs Syndrome in Women With Polycystic Ovaries

1975 • 19 citations

Introduction

1971 • 16 citations

EFFECT OF CORTISOL ON THE PRODUCTION OF OVARIAN ANDROGENS

1964 • 14 citations

Long-term steroid therapy in patients with adrenogenital syndrome.

1975 • 12 citations

The Polycystic Ovary. V. Alternate Pathways of Steroid Aromatization in Normal, Pregnancy and Polycystic Ovaries

1965 • 11 citations