Antitumor Effect of Recombinant Human Interleukin‐1β Alone and in Combination with Natural Human Tumor Necrosis Factor‐α

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.

1988 • 1,039 citations

Stimulation of neutrophils by tumor necrosis factor.

1986 • 847 citations

Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.

1986 • 496 citations

In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.

1981 • 424 citations

Accurate Identification of Experimental Pulmonary Metastases2

1966 • 418 citations

Definitive evidence that natural killer (NK) cells inhibit experimental tumor metastases in vivo.

1981 • 395 citations

Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells.

1985 • 235 citations

Human leukocytic pyrogen induces release of specific granule contents from human neutrophils.

1978 • 206 citations

Macrophage cytotoxicity: interleukin 1 as a mediator of tumor cytostasis.

1986 • 168 citations

Effect of cytokines on polymorphonuclear neutrophil infiltration in the mouse. Prostaglandin- and leukotriene-independent induction of infiltration by IL-1 and tumor necrosis factor.

1988 • 140 citations

Interleukin 1-dependent induction of both interleukin 2 secretion and interleukin 2 receptor expression by thymoma cells.

1986 • 133 citations

Purification and characterization of recombinant human interleukin-2 produced in Escherichia coli

1985 • 125 citations

Synergistic anti-proliferative activity of interleukin 1 and tumor necrosis factor.

1987 • 106 citations

Synergistic and overlapping activities of tumor necrosis factor-alpha and IL-1.

1988 • 102 citations

Antitumor effect of recombinant human interleukin 1 alpha against murine syngeneic tumors.

1986 • 86 citations

Purification and characterization of recombinant human interleukin-1β produced in Escherichia coli

1987 • 76 citations

Multiple Biological Properties of Recombinant Human Interleukin 1 (beta)

1986 • 74 citations

Simultaneous production of natural human tumor necrosis factor-alpha, -beta and interferon-alpha from BALL-1 cells stimulated by HVJ.

1988 • 65 citations

Tumor necrosis factor and IL-1 associated with plasma membranes of activated human monocytes lyse monokine-sensitive but not monokine-resistant tumor cells whereas viable activated monocytes lyse both.

1988 • 60 citations

Regulation of IL-1 and TNF-alpha expression during the differentiation of bone marrow derived macrophage.

1989 • 55 citations

Mechanism of in vitro Antitumor Effects of Interleukin 1 (IL 1)

1986 • 42 citations

Influence of reticuloendothelial blockade on the induction of tolerance and immunity by polysaccharides.

1976 • 42 citations

The effect of various cytokines on the in vitro induction of antibody-dependent cellular cytotoxicity in murine cells. Enhancement of IL-2-induced antibody-dependent cellular cytotoxicity activity by IL-1 and tumor necrosis factor-alpha.

1989 • 31 citations

Antitumor Effect of Interleukin‐1β in the Double Grafted Tumor System

1989 • 18 citations

Preventive and Antiproliferative Effects of Tumor Necrosis Factor against Experimental Hepatic Metastases of Mouse Colon‐26 Tumor

1989 • 18 citations

Antitumor effects of natural-human TNF on BDF1 mice bearing lewis lung carcinoma.

1987 • 4 citations