Molecular mechanism of the cardiotoxic action of a polypeptide neurotoxin from sea anemone on cultured embryonic cardiac cells

Determination of protein: A modification of the lowry method that gives a linear photometric response

1972 • 5,490 citations

The membrane actions of anesthetics and tranquilizers.

1972 • 2,194 citations

Chemicals as tools in the study of excitable membranes.

1974 • 918 citations

Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors

1972 • 602 citations

Existence and role of a slow inward current during the frog atrial action potential

1969 • 449 citations

Differences in Na and Ca Spikes As Examined by Application of Tetrodotoxin, Procaine, and Manganese Ions

1966 • 432 citations

Membrane Currents in Cardiac Muscle Fibers

1973 • 268 citations

Voltage clamp experiments on ventricular myocardial fibres

1970 • 255 citations

Voltage clamp experiments on frog atrial heart muscle fibres with the sucrose gap technique

1968 • 241 citations

Activation of the action potential Na+ ionophore of cultured neuroblastoma cells by veratridine and batrachotoxin

1975 • 197 citations

Sodium Uptake Associated with Activation of Action Potential Ionophores of Cultured Neuroblastoma and Muscle Cells

1973 • 188 citations

The slow inward current and the action of manganese ions in guinea-pig's myocardium

1970 • 187 citations

Sea anemone toxin:a tool to study molecular mechanisms of nerve conduction and excitation-secretion coupling.

1976 • 184 citations

Temperature-sensitive expression of differentiation in transformed myoblasts

1975 • 172 citations

Decreased rate of sodium conductance inactivation in the node of Ranvier induced by a polypeptide toxin from sea anemone

1976 • 171 citations

Selective inhibition of the transmembrane Ca conductivity of mammalian myocardial fibres by Ni, Co and Mn ions

1973 • 157 citations

Isolation and characterisation of three polypeptides with neurotoxic activity from Anemonia sulcata

1975 • 134 citations

Purification of a toxic protein from scorpion venom which activates the action potential Na+ ionophore.

1976 • 133 citations

Scorpion neurotoxin — A presynaptic toxin which affects both Na+ and K+ channels in axons

1975 • 132 citations

Specific Uncoupling of Excitation and Contraction in Mammalian Cardiac Tissue by Lanthanum

1970 • 128 citations

Slow inward current and action potential in cardiac Purkinje fibres

1971 • 122 citations

A Simple Digital‐Computer Program for Estimating the Parameters of the Hill Equation

1973 • 122 citations

Bovine kidney alkaline phosphatase. Catalytic properties, subunit interactions in the catalytic process, and mechanism of Mg2+ stimulation.

1975 • 118 citations

Constitution and properties of axonal membranes of crustacean nerves

1975 • 108 citations

(Na+, K+)-Activated Adenosinetriphosphatase of Axonal Membranes, Cooperativity and Control. Steady-State Analysis

1976 • 102 citations

Uptake and Metabolism of Fatty Acids and Analogues by Cultured Cardiac Cells from Chick Embryo

1976 • 102 citations

Amino-Acid Sequence of a Coelenterate Toxin: Toxin II from Anemonia sulcata

1976 • 89 citations

Effects of neurotoxins (veratridine, sea anemone toxin, tetrodotoxin) on transmitter accumulation and release by nerve terminals in vitro

1977 • 86 citations

Increase in PNa and PK of Cultured Heart Cells Produced by Veratridine

1969 • 52 citations

Spike electrogenesis in cultured heart cells

1969 • 44 citations

Electro-optical system for monitoring activity of heart cells in culture: Application to the study of several drugs and scorpion toxins

1974 • 43 citations

The action of a toxin from the sea Anemone Anemonia sulcata upon mammalian heart muscles

1976 • 38 citations

Two pharmacological types of cardiac slow Na+ channesl as distinguished by verapamil

1974 • 34 citations

Stimulation of sodium and calcium uptake by scorpion toxin in chick embryo heart cells

1976 • 29 citations

Toxicological and Pharmacological Studies on Sea Anemone, Calliactis polypus (Hormathiidae)

1972 • 4 citations