Medical management of advanced gastric cancer

Randomized trial comparing epirubicin, cisplatin, and fluorouracil versus fluorouracil, doxorubicin, and methotrexate in advanced esophagogastric cancer.

1997 • 875 citations

Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer

1997 • 843 citations

Randomised comparison of fluorouracil, epidoxorubicin and methotrexate (FEMTX) plus supportive care with supportive care alone in patients with non-resectable gastric cancer

1995 • 796 citations

Modified therapy with 5-fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer

1993 • 787 citations

Trends in Cancer Incidence, Survival and Mortality

2009 • 785 citations

A Southwest Oncology Group study

1993 • 778 citations

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile.

1987 • 720 citations

Increasing incidence of adenocarcinoma of the gastric cardia and adjacent sites

1990 • 400 citations

Sequential high-dose methotrexate and fluorouracil combined with doxorubicin--a step ahead in the treatment of advanced gastric cancer: a trial of the European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cooperative Group.

1991 • 394 citations

A Comparison of Three Chemotherapeutic Regimens in the Treatment of Advanced Pancreatic and Gastric Carcinoma

1985 • 393 citations

A phase III randomized study of 5-fluorouracil and cisplatin versus 5-fluorouracil, doxorubicin, and mitomycin C versus 5-fluorouracil alone in the treatment of advanced gastric cancer

1993 • 360 citations

5-Fluorouracil, Doxorubicin, and Mitomycin (FAM) Combination Chemotherapy for Advanced Gastric Cancer

1980 • 357 citations

First demonstration of anti-lymphoma activity of BCL-2 antisense molecule-G3139; Results of phase I/IIA clinical trial

1997 • 320 citations

Phase II study with the combination etoposide, doxorubicin, and cisplatin in advanced measurable gastric cancer.

1989 • 307 citations

Preoperative chemotherapy in locally advanced and nonresectable gastric cancer: a phase II study with etoposide, doxorubicin, and cisplatin.

1989 • 304 citations

FAMTX versus etoposide, doxorubicin, and cisplatin: a random assignment trial in gastric cancer.

1992 • 293 citations

A phase II study in advanced gastro-esophageal cancer using epirubicin and cisplatin in combination with continuous infusion 5-fluorouracil (ECF)

1994 • 262 citations

Gastric cancer: A 25-year review

1989 • 259 citations

Adenocarcinoma of the stomach: Review of 1,497 cases

1978 • 239 citations

Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous and by slow infusion.

1980 • 233 citations

Docetaxel (TaxotereTM) in advanced gastric cancer: results of a phase II clinical trial. EORTC Early Clinical Trials Group

1994 • 224 citations

Integration of chemotherapy into combined modality treatment of solid tumors

1974 • 182 citations

[Late phase II study of irinotecan hydrochloride (CPT-11) in advanced gastric cancer. CPT-11 Gastrointestinal Cancer Study Group].

1994 • 171 citations

A controlled study of combined 1,3-bis-(2-chloroethyl)-1-nitrosourea and 5-fluorouracil therapy for advanced gastric and pancreatic cancer

1974 • 158 citations

Cost-effectiveness of palliative chemotherapy in advanced gastrointestinal cancer

1995 • 157 citations

Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase.

1996 • 139 citations

Phase I-II study of irinotecan hydrochloride combined with cisplatin in patients with advanced gastric cancer.

1997 • 139 citations

Controlled evaluation of three drug combination regimens versus fluorouracil alone for the therapy of advanced gastric cancer. North Central Cancer Treatment Group.

1994 • 136 citations

Prognostic factors of early stage cervical cancer treated by radical hysterectomy

1995 • 128 citations

Phase III comparison of the treatment of advanced gastrointestinal cancer with bolus weekly 5-FU vs. methyl-CCNU plus bolus weekly 5-FU.A southwest oncology group study

1976 • 110 citations

An Eastern Cooperative Oncology Group evaluation of combinations of methyl-CCNU, mitomycin C, Adriamycin, and 5-fluorouracil in advanced measurable gastric cancer (EST 2277).

1984 • 105 citations

Intensive weekly chemotherapy for advanced gastric cancer using fluorouracil, cisplatin, epi-doxorubicin, 6S-leucovorin, glutathione, and filgrastim: a report from the Italian Group for the Study of Digestive Tract Cancer.

1997 • 104 citations

Sequential and combination chemotherapy of advanced gastric cancer

1976 • 101 citations

Epirubicin, cisplatin, and protracted venous infusion of 5-fluorouracil for esophagogastric adenocarcinoma: Response, toxicity, quality of life, and survival

1996 • 79 citations

Analysis of a prospectively randomized comparison of doxorubicin versus 5-fluorouracil, doxorubicin, and BCNU in advanced gastric cancer: implications for future studies.

1986 • 72 citations

Continuous 5-Fluorouracil Infusion in Advanced Gastric Carcinoma

1988 • 70 citations

A comparison of three chemotherapeutic regimens in the treatment of advanced pancreatic and gastric carcinoma. Fluorouracil vs fluorouracil and doxorubicin vs fluorouracil, doxorubicin, and mitomycin

1985 • 64 citations

Phase II-III chemotherapy studies in advanced gastric cancer. Eastern Cooperative Oncology Group.

1979 • 59 citations

Epirubucin, cisplatin, and continuous infusion 5-fluorouracil is an active and safe regimen for patients with advanced gastric cancer. An italian group for the study of digestive tract cancer (GISCAD) report

1995 • 50 citations

Dose reduction without loss of efficacy for 5-fluorouracil and cisplatin combined with folinic acid. In vitro study on human head and neck carcinoma cell lines

1991 • 43 citations

Cisplatin therapy for adenocarcinoma of the stomach.

1991 • 42 citations

High-dose MTX/5-FU and adriamycin for gastric cancer.

1983 • 39 citations

Phase-II clinical trial of 4′-epi-doxorubicin in metastatic solid tumors

1983 • 28 citations

Triazinate and Platinum Efficacy in Combination With 5-Fluorouracil and Doxorubicin: Results of a Three-Arm Randomized Trial in Metastatic Gastric Cancer

1988 • 27 citations

Studies of Baker's antifol, methotrexate, and razoxane in advanced gastric cancer: A Gastrointestinal Tumor Study Group Report.

1982 • 26 citations

Phase II trial of gemcitabine in patients with advanced gastric cancer.

1994 • 25 citations

Phase III study of 5-FU and carmustine versus 5-FU, carmustine, and doxorubicin in advanced gastric cancer.

1986 • 25 citations

Phase II trial of carboplatin in patients with adenocarcinomas of the upper gastrointestinal tract.

1985 • 18 citations

Phase II trial of epirubicin in gastric cancer.

1985 • 10 citations

High-dose chemotherapy with autologous bone marrow transplantation in the treatment of advanced gastric cancer

1993 • 8 citations