Defects of Insulin Action on Fatty Acid and Carbohydrate Metabolism in Familial Combined Hyperlipidemia

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1985 • 1,076 citations

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1989 • 799 citations

Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles.

1993 • 696 citations

Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans.

1995 • 500 citations

Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles.

1992 • 458 citations

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1989 • 414 citations

Polymorphism of apolipoprotein E

1979 • 405 citations

Radioactive and Stable Isotope Tracers in Biomedicine

1993 • 402 citations

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1987 • 395 citations

Plasma lipoproteins in familial combined hyperlipidemia and monogenic familial hypertriglyceridemia

1983 • 305 citations

Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia.

1990 • 264 citations

Insulin Regulation of Lipoprotein Lipase Activity in 3T3-L1 Adipocytes is Mediated at Posttranscriptional and Posttranslational Levels

1989 • 246 citations

Familial Combined Hyperlipidemia Workshop

1989 • 215 citations

Polymorphism of Apolipoprotein E

1980 • 212 citations

Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification

2006 • 206 citations

Substrate delivery as a determinant of hepatic apoB secretion.

1993 • 202 citations

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1984 • 201 citations

Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression.

1995 • 198 citations

Impaired fatty acid metabolism in familial combined hyperlipidemia. A mechanism associating hepatic apolipoprotein B overproduction and insulin resistance.

1993 • 198 citations

Insulin increases the synthetic rate and messenger RNA level of lipoprotein lipase in isolated rat adipocytes.

1988 • 189 citations

Familial combined hyperlipidaemia linked to the apolipoprotein AI–CIII–AIV gene cluster on chromosome 11q23q–q24

1991 • 188 citations

Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels.

1994 • 187 citations

Resistance to Insulin Suppression of Plasma Free Fatty Acid Concentrations and Insulin Stimulation of Glucose Uptake in Noninsulin-Dependent Diabetes Mellitus*

1987 • 180 citations

Stable isotopes show a direct relation between VLDL apoB overproduction and serum triglyceride levels and indicate a metabolically and biochemically coherent basis for familial combined hyperlipidemia.

1993 • 178 citations

Body fat distribution, rather than overall adiposity, influences serum lipids and lipoproteins in healthy men independently of age

1995 • 170 citations

Linkage of atherogenic lipoprotein phenotype to the low density lipoprotein receptor locus on the short arm of chromosome 19.

1992 • 165 citations

Heterozygous lipoprotein lipase deficiency due to a missense mutation as the cause of impaired triglyceride tolerance with multiple lipoprotein abnormalities.

1993 • 145 citations

Oleate-mediated stimulation of apolipoprotein B secretion from rat hepatoma cells. A function of the ability of apolipoprotein B to direct lipoprotein assembly and escape presecretory degradation.

1992 • 144 citations

Familial combined hyperlipidemia and abnormal lipoprotein lipase.

1992 • 144 citations

Apolipoprotein, low density lipoprotein subfraction, and insulin associations with familial combined hyperlipidemia. Study of Utah patients with familial dyslipidemic hypertension.

1989 • 138 citations

DNA polymorphisms in and around the Apo-A1-CIII genes and genetic hyperlipidemias.

1987 • 113 citations

Impaired activation of adipocyte lipolysis in familial combined hyperlipidemia.

1995 • 110 citations

A mutation in the promoter of the lipoprotein lipase (LPL) gene in a patient with familial combined hyperlipidemia and low LPL activity.

1995 • 108 citations

Genetic predictors of FCHL in four large pedigrees. Influence of ApoB level major locus predicted genotype and LDL subclass phenotype.

1994 • 93 citations

Insulin resistance, glucose intolerance, and hyperinsulinemia. Hypertriglyceridemia versus hypercholesterolemia.

1993 • 88 citations

Changes of lipolytic enzymes cluster with insulin resistance syndrome

1995 • 86 citations

Genetics and molecular biology of familial combined hyperlipidemia

1993 • 83 citations

Genetic markers in the apo AI-CIII-AIV gene cluster for combined hyperlipidemia, hypertriglyceridemia, and predisposition to atherosclerosis

1993 • 82 citations

The LPL gene in individuals with familial combined hyperlipidemia and decreased LPL activity.

1994 • 77 citations

LDL Physical and Chemical Properties in Familial Combined Hyperlipidemia

1995 • 77 citations

Immunoturbidimetric assays for serum apolipoproteins A1 and B using Cobas Bio centrifugal analyser.

1988 • 68 citations

Complex segregation analysis provides evidence for a major gene acting on serum triglyceride levels in 55 British families with familial combined hyperlipidemia.

1994 • 67 citations

Oleate-mediated Stimulation of Apolipoprotein B Secretion from Rat Hepatoma Cells

1992 • 56 citations

Relation of plasma triglyceride and apoB levels to insulin-mediated suppression of nonesterified fatty acids. Possible explanation for sex differences in lipoprotein pattern.

1993 • 54 citations

Influence of insulin resistance, secretion, and clearance on serum cholesterol, triglycerides, lipoprotein cholesterol, and blood pressure in healthy men.

1992 • 50 citations

Insulin Resistance with Respect to Lipolysis in Non‐diabetic Relatives of European Patients with Type 2 Diabetes

1995 • 35 citations

Study of DNA polymorphisms of the apolipoprotein AI-CIII-AIV gene cluster in patients with peripheral arterial disease

1989 • 20 citations

The potential role of acylation stimulating protein as a determinant of plasma triglyceride clearance and intracellular triglyceride synthesis

1992 • 17 citations