Towards understanding molecular modes of probiotic action

Host-Bacterial Mutualism in the Human Intestine

2005 • 4,852 citations

Use of Plant Growth-Promoting Bacteria for Biocontrol of Plant Diseases: Principles, Mechanisms of Action, and Future Prospects

2005 • 2,384 citations

Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine

2001 • 2,152 citations

Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont

2005 • 1,117 citations

Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA

2003 • 983 citations

The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract

2002 • 929 citations

Lactobacilli Differentially Modulate Expression of Cytokines and Maturation Surface Markers in Murine Dendritic Cells

2002 • 895 citations

The serpin superfamily of proteinase inhibitors: structure, function, and regulation.

1994 • 879 citations

Commercialization and Implementation of Biocontrol

2005 • 849 citations

Selective probiotic bacteria induce IL-10–producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell–specific intercellular adhesion molecule 3–grabbing nonintegrin

2005 • 743 citations

LactobacillusTherapy for Acute Infectious Diarrhea in Children: A Meta-analysis

2002 • 610 citations

Modulation of human dendritic cell phenotype and function by probiotic bacteria

2004 • 559 citations

Probiotic Bacterium Prevents Cytokine-induced Apoptosis in Intestinal Epithelial Cells

2002 • 544 citations

Probiotics: determinants of survival and growth in the gut

2001 • 507 citations

NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells byEscherichia coliNissle 1917: a Novel Effect of a Probiotic Bacterium

2004 • 469 citations

Probiotic and other functional microbes: from markets to mechanisms

2005 • 451 citations

Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids

2005 • 422 citations

Functional Analysis of Putative Adhesion Factors in Lactobacillus acidophilus NCFM

2005 • 364 citations

Adhesion of probiotic strains to the intestinal mucosa and interaction with pathogens

2003 • 352 citations

Probiotics as Biotherapeutic Agents: Present Knowledge and Future Prospects

2003 • 334 citations

Probiotics inhibit nuclear factor-κB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition

2004 • 323 citations

PASSCLAIM1?Gut health and immunity

2004 • 304 citations

Biodiversity-Based Identification and Functional Characterization of the Mannose-Specific Adhesin ofLactobacillus plantarum

2005 • 299 citations

Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells

2005 • 296 citations

Live Lactobacillus reuteri Is Essential for the Inhibitory Effect on Tumor Necrosis Factor Alpha-Induced Interleukin-8 Expression

2004 • 288 citations

Alive and Dead Lactobacillus rhamnosus GG Decrease Tumor Necrosis Factor-α–Induced Interleukin-8 Production in Caco-2 Cells

2005 • 287 citations

Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function

2004 • 235 citations

Identification ofLactobacillus plantarumGenes That Are Induced in the Gastrointestinal Tract of Mice

2004 • 234 citations

Genomic features of lactic acid bacteria effecting bioprocessing and health

2005 • 224 citations

Probiotic therapy of intestinal inflammation and infections.

2005 • 206 citations

Functional Foods: A Survey of Health Claims, Pros and Cons, and Current Legislation

2005 • 200 citations

Genomic features of lactic acid bacteria effecting bioprocessing and health

2005 • 195 citations

Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis

2004 • 184 citations

In Silico Reconstruction of the Metabolic Pathways of Lactobacillus plantarum : Comparing Predictions of Nutrient Requirements with Those from Growth Experiments

2005 • 178 citations

The Importance of Guidelines in the Development and Application of Probiotics

2005 • 174 citations

Bacterial replacement therapy: adapting ‘germ warfare’ to infection prevention

2003 • 165 citations

ProbioticLactobacillusspp. DiminishHelicobacter hepaticus-Induced Inflammatory Bowel Disease in Interleukin-10-Deficient Mice

2005 • 163 citations

Identification and Inactivation of Genetic Loci Involved withLactobacillus acidophilusAcid Tolerance

2004 • 143 citations

Genetic Characterization of the Bile Salt Response in Lactobacillus plantarum and Analysis of Responsive Promoters In Vitro and In Situ in the Gastrointestinal Tract

2004 • 138 citations

Identification of Lactobacillus reuteri Genes Specifically Induced in the Mouse Gastrointestinal Tract

2003 • 126 citations

Effects of on genes expression pattern in small bowel mucosa

2005 • 123 citations

A High-Molecular-Mass Surface Protein (Lsp) and Methionine Sulfoxide Reductase B (MsrB) Contribute to the Ecological Performance of Lactobacillus reuteri in the Murine Gut

2005 • 121 citations

Probiotics in inflammatory bowel disease: possible mechanisms of action.

2005 • 121 citations

Microarray Analysis of a Two-Component Regulatory System Involved in Acid Resistance and Proteolytic Activity inLactobacillus acidophilus

2005 • 118 citations

Genotypic and Phenotypic Studies of Murine Intestinal Lactobacilli: Species Differences in Mice with and without Colitis

2004 • 92 citations

Permanent Colonization by Lactobacillus casei Is Hindered by the Low Rate of Cell Division in Mouse Gut

2004 • 90 citations

Is <i>Lactobacillus rhamnosus</i> GG Effective in Preventing the Onset of Antibiotic-Associated Diarrhoea: A Systematic Review

2005 • 89 citations

Probiotics as a Treatment Strategy for Gastrointestinal Diseases?

2005 • 75 citations

Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment

2004 • 69 citations

Weight of evidence needed to substantiate a health effect for probiotics and prebiotics

2004 • 53 citations

Differential Activities of FourLactobacillus caseiPromoters during Bacterial Transit through the Gastrointestinal Tracts of Human-Microbiota-Associated Mice

2005 • 43 citations

Bacillus clausii effect on gene expression pattern in small bowel mucosa using DNA microarray analysis

2005 • 36 citations

Initiation of Protein Synthesis by a Labeled Derivative of theLactobacillus caseiDN-114 001 Strain during Transit from the Stomach to the Cecum in Mice Harboring Human Microbiota

2004 • 30 citations