Die enzymatische Ribonucleotid‐Reduktion: Biosyntheseweg der Desoxyribonucleotide

Enzymatic Synthesis of Deoxyribonucleotides

1964 • 917 citations

Inhibition of ribonucleoside diphosphate reductase by hydroxyurea.

1968 • 423 citations

Regulation of Mammalian Deoxyribonucleotide Biosynthesis by Nucleotides as Activators and Inhibitors

1966 • 395 citations

Iron and Free Radical in Ribonucleotide Reductase

1973 • 364 citations

Ribonucleotide Reductase and Cell Proliferation

1970 • 307 citations

Effects of Thymidine on Deoxyribonucleoside Triphosphate Pools and Deoxyribonucleic Acid Synthesis in Chinese Hamster Ovary Cells

1973 • 299 citations

Thioredoxin. 6. The Amino Acid Sequence of the Protein from Escherichia coli B

1968 • 274 citations

ENZYMATIC SYNTHESIS AND BREAKDOWN OF DESOXYRIBOSE PHOSPHATE

1952 • 255 citations

Physicochemical Characterization of Ribonucleoside Diphosphate Reductase from Escherichia coli

1973 • 172 citations

The Involvement of the Thioredoxin System in the Reduction of Methionine Sulfoxide and Sulfate

1970 • 169 citations

Ribonucleoside Diphosphate Reductase. Purification of the two Subunits, Proteins B1 and B2

1969 • 164 citations

Deoxyribonucleotide Pools and Deoxyribonucleic Acid Synthesis in Cultured Mouse Embryo Cells

1970 • 161 citations

A rapid quantitative determination of deoxyribonucleoside triphosphates based on the enzymatic synthesis of DNA

1969 • 157 citations

Cell-cycle-dependent variations of deoxyribonucleoside triphosphate pools in chinese hamster cells

1973 • 156 citations

Ribonucleoside diphosphate reductase

1969 • 146 citations

Nuclear and Cytoplasmic Pools of Deoxyribonucleoside Triphosphates in Chinese Hamster Ovary Cells

1974 • 145 citations

Formation of Deoxycytidine Phosphates from Cytidine Phosphates in Extracts from Escherichia coli

1961 • 142 citations

Inhibition of ribonucleoside diphosphate reductase by 1-formylisoquinoline thiosemicarbazone and related compounds

1970 • 141 citations

An Enzymatic Method for the Determination of dCTP and dGTP in Picomole Amounts

1970 • 140 citations

Deoxyribonucleoside‐Triphosphate Pools and DNA Synthesis in Synchronized Hamster Cells

1973 • 136 citations

Zum Mechanismus der Propandioldehydrase-Reaktion

1966 • 125 citations

Enzymatic Synthesis of Deoxyribonucleotides

1966 • 125 citations

INCORPORATION OF C14 TOTALLY LABELED NUCLEOSIDES INTO NUCLEIC ACIDS

1953 • 124 citations

PYRIMIDINE NUCLEOSIDES AS PRECURSORS OF PYRIMIDINES IN POLYNUCLEOTIDES

1950 • 122 citations

The Control of Nucleotide Biosynthesis

1968 • 118 citations

Purification of a Thioredoxin System from Yeast

1970 • 118 citations

Thioredoxin Reductase

1967 • 114 citations

Chromatographic Separations of Cytosine Containing Compounds.

1958 • 114 citations

Cobamide stimulation of the reduction of ribotides to deoxyribotides in LactobacillusLeichmannii

1964 • 109 citations

Determination of the nucleoside triphosphate contents of eggs and oocytes of Xenopus laevis

1972 • 105 citations

Levels of Ribonucleotide Reductase Activity during the Division Cycle of the L Cell

1968 • 103 citations

Self‐Organization of Molecular Systems and Evolution of the Genetic Apparatus

1972 • 101 citations

Induction of Enzymes Involved in the Catabolism of Deoxyribonucleosides and Ribonucleosides in Escherichia coli K 12

1971 • 100 citations

Deoxyribonucleoside triphosphate pools in synchronized and drug-inhibited L929 cells

1971 • 98 citations

Ribonucleotide Reductase from Regenerating Rat Liver

1969 • 96 citations

Cobamides and ribonucleotide reduction. XI. Direct spectrophotometric observation of an intermediate formed from deoxyadenosylcobalamin in ribonucleotide reduction

1973 • 95 citations

Defective Gene Product in dnaF Mutant of Escherichia coli

1972 • 89 citations

The Biosynthesis of Deoxyribonucleotides

1968 • 89 citations

The effects of ferrous ion and dithioerythritol on inhibition by hydroxyruea of ribonucleotide reductase.

1969 • 88 citations

Nature of DNA Precursors

1971 • 85 citations

Enzymatic synthesis of deoxyribonucleotides, 8. The effects of ATP and dATP in the CDP reductase system from E. coli.

1965 • 83 citations

Cobamides and Ribonucleotide Reduction

1974 • 82 citations

Cobamides and ribonucleotide reduction. IX. Monomeric, allosteric enzyme with a single polypeptide chain. Ribonucleotide reductase of Lactobacillus leichmannii

1972 • 79 citations

Ribonucleotide Reductase of Rabbit Bone Marrow

1972 • 79 citations

Selbstorganisation molekularer Systeme und die Evolution des genetischen Apparats

1972 • 78 citations

Cobamides and Ribonucleotide Reduction

1968 • 78 citations

Synthesis of ATP‐ and dATP‐Substituted Sepharoses and Their Application in the Purification of Phage‐T4–Induced Ribonucleotide Reductase

1972 • 76 citations

Cobamides and Ribonucleotide Reduction

1967 • 74 citations

Enzymatic Reactions Involving Corrinoids

1968 • 73 citations

Ribonucleotide reductase activity during the cell cycle of Saccharomyces cerevisiae

1973 • 69 citations

Enzymatic Reduction of Ribonucleotides

1967 • 67 citations

Thioredoxin from Lactobacillusleichmannii and its role as hydrogen donor for ribonucleoside triphosphate reductase

1966 • 66 citations

B ₁₂ Coenzyme-dependent Ribonucleotide Reductase in Rhizobium Species and the Effects of Cobalt Deficiency on the Activity of the Enzyme

1969 • 64 citations

The Mechanism of Action of Cobamide Coenzyme in the Ribonucleotide Reductase Reaction

1967 • 63 citations

Molecular mechanisms of liver regeneration

1969 • 61 citations

Specific activation of the DNA-synthesizing apparatus in contact-inhibited mouse kidney cells by polyoma virus.

1967 • 59 citations

Ribonucleoside Diphosphate Reductase Induced by Bacteriophage T4

1972 • 59 citations

Cascade Activation of Genome Transcription in Wheat

1973 • 56 citations

Regulation of Cobamide-dependent Ribonucleotide Reductase by Allosteric Effectors and Divalent Cations

1967 • 55 citations

A NEW RIBONUCLEOTIDE REDUCTASE SYSTEM AFTER INFECTION WITH PHAGE T4

1969 • 53 citations

Reduction of cytidine nucleotides to deoxycytidine nucleotides by mammalian enzymes

1962 • 52 citations

A convenient assay for ADP reductase activity using Dowex-1-borate columns

1973 • 50 citations

Studies on the Structure of T4 Thioredoxin

1972 • 49 citations

Ribonucleotide Reductase from Euglena gracilis, a Deoxyadenosylcobalamin-dependent Enzyme

1970 • 49 citations

Yeast Thioredoxin

1971 • 48 citations

5′-deoxyadenosylcobalamin-dependent ribonucleotide reductase: A survey of its distribution

1972 • 47 citations

Cobamides and Ribonucleotide Reduction

1966 • 45 citations

The Synthesis of a 5′-Deoxyadenosylcobalamin-agarose Adsorbent and Its Utility in the Purification of Ribonucleotide Reductase

1972 • 44 citations

Control of pyrimidine biosynthesis by phage T4: Mutants unable to catalyze the reduction of cytidine diphosphate

1969 • 44 citations

Induction of a Reductive Pathway for Deoxyribonucleotide Synthesis during Early Embryogenesis of the Sea Urchin

1972 • 43 citations

Hydrogen Donor Specificity of Cobamide-dependent Ribonucleotide Reductase and Allosteric Regulation of Substrate Specificity

1966 • 41 citations

Cobamides and ribonucleotide reduction. X. Electron paramagnetic resonance studies on cobalamin-dependent ribonucleotide reduction

1972 • 41 citations

Deoxyribonucleotide Pools during Liver Regeneration

1973 • 40 citations

Some properties of the ribonucleotide reductase from Rhizobium meliloti

1968 • 40 citations

The Isolation and Primary Structure of a Peptide Containing the Oxidation-Reduction Active Cystine of Escherichia coli Thioredoxin Reductase

1972 • 38 citations

Reduction of 5′-cytidylic acid to deoxycytidylic acid by mammalian enzymes

1960 • 38 citations

A Mutant of Escherichia coli Defective in Ribonucleosidediphosphate Reductase

1973 • 38 citations

Purification of Thioredoxin from Rat Novikoff Ascites Hepatoma

1973 • 37 citations

The Biosynthesis of Deoxyribonucleic Acid by the Chick Embryo

1961 • 37 citations

Cobamides and Ribonucleotide Reduction. IV. Stereochemistry of Hydrogen Transfer to the Deoxyribonucleotide^*

1967 • 35 citations

Regulation by nucleotides of the activity of partially purified ribonucleotide reductase from rat embryos.

1968 • 33 citations

Separation of ribonucleosides from deoxyribo-nucleosides and arabinonucleosides by thin-layer chromatography

1968 • 32 citations

Conversion of cytidine 5′-phosphate to deoxycytidine 5′-phosphate in cell-free mammalian extracts

1960 • 32 citations

Reduction of a Disulphide Bond of Ribonucleotide Reductase by the Dithiol Substrate

1967 • 32 citations

[21] Mammalian ribonucleoside diphosphate reductases

1967 • 30 citations

Purification and Properties of Ribonucleotide Reductase from Leukemic Mouse Spleen

1970 • 30 citations

Ribonucleotide reductase from saccharomyces cerevisiae

1970 • 30 citations

Synthesis of ribose and of adenine nucleotides containing oxygen-18

1970 • 29 citations

Pentose synthesis in Escherichia coli

1969 • 28 citations

Purification and Properties of Rat‐Liver Thioredoxin

1972 • 28 citations

Ribonucleotide Reductase in Developing Brain

1972 • 27 citations

Ribonucleotide reductase from Thermus X-1, a thermophilic organism

1973 • 27 citations

Thioredoxin Reductase from Rat Liver

1973 • 27 citations

Enzymatic Synthesis of Deoxyribonucleotides. VII. Studies on the Hydrogen Transfer with Tritiated Water^*

1965 • 26 citations

Nucleoside Antibiotics

1968 • 26 citations

Enzymatic Synthesis of Deoxyribonucleotides

1967 • 26 citations

Stereochemistry of deoxygenation of ribonucleotides. Specifically 2'-monodeuterated 2'-deoxycytidines

1971 • 25 citations

Stoichiometry of the pyrimidine deoxyribonucleoside 2'-hydroxylase reaction and of the conversions of 5-hydroxymethyluracil to 5-formyluracil and of the latter to uracil-5-carboxylic acid

1972 • 24 citations

Interaction of ribonucleotide reductase with ribonucleotide analogs

1971 • 24 citations

Enzymatic Synthesis of Deoxyribonucleotides

1967 • 23 citations

Effects of Oxidation of Tryptophan Residues in Thioredoxin from Escherichia coli by N-Bromosuccinimide

1973 • 22 citations

Purification and characterization of yeast thioredoxin reductase

1973 • 21 citations

Nucleoside Antibiotics

1968 • 20 citations

The Bacillus megaterium ribonucleotide reductase: Evidence for a B12 coenzyme requirement

1973 • 19 citations

A genetic approach to the study of cytotoxicity and resistance of cultured Chinese hamster cells in the presence of cytosine arabinoside.

1972 • 18 citations

Control by Bacteriophage T4 of the Reduction of Adenosine Nucleotide to Deoxyadenosine Nucleotide

1972 • 17 citations

The biosynthesis of DNA by insects

1971 • 17 citations

Elementary Particles and Cosmology

1972 • 17 citations

Ribonucleotide reductase in human bone marrow: Lack of stimulation by 5′-deoxyadenosyl B12

1969 • 16 citations

Ribonucleotide reductase activity in cell-free extracts of Yaba poxvirus tumor and normal monkey tissues.

1969 • 15 citations

Ribonucleotide reductase. Studies with oxygen-18-labeled substrates

1969 • 14 citations

Possible Intermediates in the Biosynthesis of Deoxyribonucleotides. I. The Synthesis of Cytidine 2′-Phosphate 5′-Diphosphate

1964 • 14 citations

Enzymatic Ribonucleotide Reduction in Wheat

1973 • 14 citations

Desoxyribonucleosidtriphosphatgehalte in Yoshida-Ascitestumorzellen

1973 • 8 citations

Incorporation of deoxyribonucleoside diphosphates into DNA-like polydeoxyribonucleotides: Experiments with an enzyme and toluene-treated cells from wild-type Escherichia coli

1972 • 6 citations

Ribonucleoside diphosphate reductase from escherichia coli: A new approach to the problem of stereospecificity

1971 • 5 citations