Selective inhibition of endothelial cell proliferation by fumagillin is not due to differential expression of methionine aminopeptidases

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

1997 • 622 citations

N-Terminal processing: the methionine aminopeptidase and Nα-acetyl transferase families

1998 • 444 citations

Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin

1998 • 431 citations

Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin

1997 • 416 citations

Vasculogenesis, Angiogenesis, and Growth Factors: Ephrins Enter the Fray at the Border

1998 • 389 citations

Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases.

1995 • 284 citations

Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes.

1995 • 249 citations

Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470)

1994 • 246 citations

Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470; AGM-1470).

1993 • 164 citations

A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells.

1994 • 143 citations

The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase

1998 • 125 citations

The Treatment of Amebiasis with Fumagillin

1952 • 115 citations

TNP-470 (AGM-1470): Mechanisms of action and early clinical development

1996 • 114 citations

The eukaryotic initiation factor 2-associated 67-kDa polypeptide (p67) plays a critical role in regulation of protein synthesis initiation in animal cells.

1992 • 94 citations

Roles of a 67-kDa polypeptide in reversal of protein synthesis inhibition in heme-deficient reticulocyte lysate.

1988 • 81 citations

Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein (p67)

1993 • 69 citations

Significant inhibition of endothelial cell growth in tumor vasculature by an angiogenesis inhibitor, TNP-470 (AGM-1470).

1994 • 68 citations

Induction of Apoptosis Due to Lowering the Level of Eukaryotic Initiation Factor 2-Associated Protein, p67, from Mammalian Cells by Antisense Approach

1999 • 43 citations

Molecular cloning of a human complementary DNA encoding an initiation factor 2-associated protein (p67)

1995 • 33 citations

Therapeutic potential of the anti‐angiogenesis drug TNP‐470

1998 • 23 citations