Muromonab CD3

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens

1979 • 1,480 citations

OKT3: A monoclonal anti-human T lymphocyte antibody with potent mitogenic properties

1980 • 718 citations

A Randomized Clinical Trial of OKT3 Monoclonal Antibody for Acute Rejection of Cadaveric Renal Transplants

1985 • 697 citations

Use of Monoclonal Antibodies to T-Cell Subsets for Immunologic Monitoring and Treatment in Recipients of Renal Allografts

1981 • 511 citations

Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex

1982 • 494 citations

TREATMENT OF ACUTE RENAL ALLOGRAFT REJECTION WITH OKT3 MONOCLONAL ANTIBODY

1981 • 389 citations

Antithymocyte Globulin Treatment in Patients with Aplastic Anemia

1983 • 316 citations

Infections with Cytomegalovirus and Other Herpesviruses in 121 Liver Transplant Recipients: Transmission by Donated Organ and the Effect of OKT3 Antibodies

1988 • 314 citations

Does OKT3 monoclonal antibody react with an antigen-recognition structure on human T cells?

1981 • 306 citations

Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.

1982 • 306 citations

In vivo effects of murine hybridoma monoclonal antibody in a patient with T-cell leukemia

1981 • 260 citations

A monoclonal antibody blocking human T cell function

1980 • 239 citations

Surface Structures Involved in Target Recognition by Human Cytotoxic T Lymphocytes

1982 • 238 citations

USE OF ANTI-T-CELL MONOCLONAL ANTIBODY OKT3 TO PREVENT ACUTE GRAFT-VERSUS-HOST DISEASE IN ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR ACUTE LEUKAEMIA

1982 • 220 citations

Human in vivo antigenic modulation induced by the anti‐T cell OKT3 monoclonal antibody

1982 • 199 citations

ANTI-IDIOTYPIC AND NON-ANTI-INDIOTYPIC ANTIBODIES TO OKT3 ARISING DESPITE INTENSE IMMUNOSUPPRESSION

1986 • 190 citations

Restriction of the human in vivo immune response against the mouse monoclonal antibody OKT3.

1986 • 186 citations

Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu-2a antibodies.

1982 • 185 citations

Complications and Monitoring of OKT3 Therapy

1988 • 178 citations

PRETREATMENT OF DONOR BONE MARROW WITH MONOCLONAL ANTIBODY OKT3 FOR PREVENTION OF ACUTE GRAFT-VERSUS-HOST DISEASE IN ALLOGENEIC HISTOCOMPATIBLE BONE-MARROW TRANSPLANTATION

1982 • 153 citations

The Human T-Cell Receptor

1985 • 152 citations

Treatment of refractory cardiac allograft rejection with OKT3 monoclonal antibody

1987 • 135 citations

Treatment of severe aplastic anaemia with antilymphocyte globulin or bone-marrow transplantation.

1981 • 130 citations

Comparison of Three Immunosuppressive Regimens in Cadaver Renal Transplantation: Long-Term Cyclosporine, Short-Term Cyclosporine Followed by Azathioprine and Prednisolone, and Azathioprine and Prednisolone without Cyclosporine

1988 • 127 citations

OKT3 MONOCLONAL ANTIBODY PLASMA LEVELS DURING THERAPY AND THE SUBSEQUENT DEVELOPMENT OF HOST ANTIBODIES TO OKT3

1986 • 121 citations

EVOLVING USE OF OKT3 MONOCLONAL ANTIBODY FOR TREATMENT OF RENAL ALLOGRAFT REJECTION

1984 • 117 citations

Antibody directed at a surface structure inhibits cytolytic but not suppressor function of human T lymphocytes

1981 • 115 citations

A RANDOMIZED CLINICAL TRIAL COMPARING OKT3 AND STEROIDS FOR TREATMENT OF HEPATIC ALLOGRAFT REJECTION

1987 • 114 citations

INCREASED INFECTIONS ASSOCIATED WITH THE USE OF OKT3 FOR TREATMENT OF STEROID-RESISTANT REJECTION IN RENAL TRANSPLANTATION1 Pressented at the 6th Annual Meeting of the American Society of Transplant Physicians, May 1987, Chicago, IL

1988 • 112 citations

RANDOMIZED PROSPECTIVE TRIAL OF OKT3 FOR EARLY PROPHYLAXIS OF REJECTION AFTER LIVER TRANSPLANTATION

1989 • 103 citations

ONE-MONTH PROPHYLACTIC USE OF OKT3 IN CADAVER KIDNEY TRANSPLANT RECIPIENTS

1988 • 101 citations

The Human Immune Response to the OKT3 Monoclonal Antibody Is Oligoclonal

1986 • 98 citations

T cell unresponsiveness to the mitogenic activity of OKT3 antibody results from a deficiency of monocyte Fc gamma receptors for murine IgG2a and inability to cross-link the T3-Ti complex.

1985 • 90 citations

Human gamma interferon production by leukocytes induced with monoclonal antibodies recognizing T cells.

1981 • 85 citations

Overview of the development of Orthoclone OKT3: monoclonal antibody for therapeutic use in transplantation.

1987 • 75 citations

USE OF ANTITHYMOCYTE GLOBULIN FOR REVERSAL OF ACUTE ALLOGRAFT REJECTION

1979 • 72 citations

Successful reversal of acute cardiac allograft rejection with OKT*3 monoclonal antibody.

1987 • 65 citations

REEXPOSURE TO OKT3 IN RENAL ALLOGRAFT RECIPIENTS

1988 • 65 citations

Nosocomial Aseptic Meningitis Associated With Administration of OKT3

1988 • 62 citations

The Use of OKT3 in Cadaveric Renal Transplantation for Rejection That Is Unresponsive to Conventional Anti-Rejection Therapy

1988 • 60 citations

A Prospective Study on the Use of Monoclonal Anti—T3-Cell Antibody (OKT3) to Treat Steroid-Resistant Liver Transplant Rejection

1987 • 59 citations

EFFECTIVENESS OF A SECOND COURSE OF 0KT3 MONOCLONAL ANTI-T CELL ANTIBODY FOR TREATMENT OF RENAL ALLOGRAFT REJECTION

1988 • 58 citations

Long term use of intravenous immune globulin in patients with primary immunodeficiency diseases: Inadequacy of current dosage practices and approaches to the problem

1982 • 57 citations

Early Use of OKT3 Monoclonal Antibody in Renal Transplantation to Prevent Rejection

1988 • 54 citations

Clinical development of Orthoclone OKT3.

1987 • 53 citations

REVERSAL OF TRANSPLANT REJECTION BY MONOCLONAL ANTIBLAST ANTIBODY

1983 • 53 citations

TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE WITH MONOCLONAL ANTIBODY OKT3

1984 • 52 citations

Impact of Orthoclone OKT3 on liver transplantation.

1987 • 48 citations

SUCCESSFUL RETREATMENT OF ALLOGRAFT REJECTION WITH OKT3

1989 • 44 citations

REMOVAL OF MARROW T CELLS WITH OKT3-OKT11 MONOCLONAL ANTIBODIES AND COMPLEMENT TO PREVENT ACUTE GRAFT-VERSUS-HOST DISEASE

1985 • 44 citations

A Comparison of OKT3 Monoclonal Antibody and Corticosteroids in the Treatment of Acute Renal Allograft Rejection

1988 • 40 citations

ANTITHYMOCYTE GLOBULIN (ATGAM) IN RENAL ALLOGRAFT RECIPIENTS

1979 • 40 citations

Use of Orthoclone OKT3 monoclonal antibody in cardiac transplantation: early experience with rejection prophylaxis and treatment of refractory rejection.

1987 • 39 citations

Unusually restricted anti‐isotype human immune response to OKT3 monoclonal antibody

1984 • 39 citations

Monoclonal Antibodies for the Diagnosis and Treatment of Transplant Rejection

1984 • 36 citations

Differentiation human leukocyte antigens: a proposed nomenclature

1984 • 32 citations

Experience With Orthoclone OKT3 Monoclonal Antibody in Liver Transplantation

1988 • 31 citations

EFFECT OF ANTILYPHOCYTE-GLOBULIN POTENCY ON SURVIVAL OF CADAVER RENAL TRANSPLANTS

1977 • 31 citations

Graft‐versus‐host disease prophylaxis with anti‐T‐cell monoclonal antibody OKT3, prednisone and methotrexate in allogeneic bone‐marrow transplantation

1985 • 30 citations

OKT3 SALVAGE THERAPY IN A QUADRUPLE IMMUNO SUPPRESSIVE PROTOCOL IN CADAVERIC RENAL TRANSPLANTATION

1989 • 28 citations

OKT3 monoclonal antibody inhibits cytotoxic T lymphocyte mediated cell lysis

1981 • 27 citations

Comparison of Antimouse and Antihorse Antibody Production during the Treatment of Allograft Rejection with OKT3 or Antithymocyte Globulin

1987 • 27 citations

A MONOCLONAL ANTI-PAN-T-CELL ANTIBODY IN VITRO AND IN VIVO STUDIES

1983 • 27 citations

Orthoclone OKT3 treatment of acute renal allograft rejection in patients receiving maintenance cyclosporine therapy.

1987 • 25 citations

A U.S. clinical study of Orthoclone OKT3 in renal transplantation.

1987 • 25 citations

ORTHOCLONE OKT3 in Treatment of Allografts Rejected Under Cyclosporine-Steroid Therapy.

1986 • 24 citations

INFLUENCE OF LOW-DOSE CYCLOSPORINE ON THE OUTCOME OF TREATMENT WITH OKT3 FOR ACUTE RENAL ALLOGRAFT REJECTION

1989 • 23 citations

OKT3 Rescue in Refractory Renal Rejection

1987 • 21 citations

OKT3 monoclonal antibody in pediatric kidney transplant recipients with recurrent and resistant allograft rejection

1987 • 21 citations

OKT3 and pulmonary capillary permeability.

1987 • 19 citations

The use of OKT3 to treat steroid-resistant renal allograft rejection in patients receiving cyclosporine.

1987 • 19 citations

Use of a Brief Steroid Trial Before Initiating OKT3 Therapy for Renal Allograft Rejection

1988 • 18 citations

Cadaveric renal transplantation in the cyclosporine and OKT3 eras.

1988 • 18 citations

Orthoclone OKT3 monoclonal antibody reversal of hepatic and cardiac allograft rejection unresponsive to conventional immunosuppressive treatments.

1987 • 18 citations

OKT3 Rescue Therapy in Pancreas-Allograft Rejection

1989 • 17 citations

OKT3 monoclonal antibody reversal of acute renal allograft rejection unresponsive to conventional immunosuppressive treatments.

1986 • 13 citations

Nosocomial aseptic meningitis associated with administration of OKT3

1988 • 13 citations

Monoclonal anti-T12 antibody as therapy for renal allograft rejection.

1983 • 12 citations

OKT3 induces suppressor cells for mixed lymphocyte and PHA mitogenic responses in human peripheral lymphocytes

1981 • 10 citations

LYMPHOCYTE FUNCTION IN PATIENTS TREATED WITH MONOCLONAL ANTI-T3 ANTIBODY FOR ACUTE CADAVERIC RENAL ALLOGRAFT REJECTION

1984 • 9 citations

Monoclonal Antibody Therapy with Ciclosporin and Steroids in Nonmatched Cadaveric Renal Transplants

1987 • 9 citations

Monoclonal Antilymphocyte Antibody (OKT3) Treatment of Acute Renal Allograft Rejection

1987 • 8 citations

A quantitative study of the binding of ALS to various cell types.

1971 • 8 citations

Use of Orthoclone OKT3 as treatment of acute renal allograft rejection and as first-line therapy in kidney transplantation.

1988 • 7 citations

Anti-thymocyte globulin effective in the treatment of aplastic anemia does not stimulate granulocyte precursor cells.

1981 • 7 citations

Immunosuppressive efficacy of vincristine in heart transplantation: a preliminary report.

1987 • 5 citations

Allogeneic bone marrow transplantation: the monitoring of granulocyte macrophage colonies following the collection of bone marrow mononuclear cells and after the subsequent in‐vitro cytolysis of OKT3 positive lymphocytes

1983 • 5 citations

Effect of OKT3 on survival and rate of retransplantation.

1987 • 5 citations

Histologic response to OKT3 therapy for hepatic allograft rejection.

1987 • 5 citations

Rescue of severe steroid-resistant rejection with OKT3.PAN.

1987 • 5 citations

Cyclosporin-A and the OKT3 monoclonal antibody exert their respective inhibitory and mitogenic activity on T cells by interacting with the same receptors.

1982 • 4 citations

Rejection prophylaxis with murine monoclonal CD-3 antibody (OKT3): considerations for early hospital discharge.

1989 • 4 citations

OKT3 delays rejection crises after heart transplantation.

1989 • 3 citations

Diagnostic and Therapeutic Applications of Monoclonal Antibodies to Human T-Cell Subsets in Renal Transplant Recipients

1983 • 3 citations

Monitoring immunosuppression following renal transplantation.

1983 • 3 citations

[Preventive treatment of rejection by the prolonged administration of OKT3: decrease of the immune response of the host].

1987 • 3 citations

Infections in patients receiving OKT3 monoclonal antibody for cardiac rejection: results of a small clinical trial.

1988 • 3 citations

OKT3 treatment of steroid- and/or anti-thymocyte globulin-resistant renal allograft rejection occurring on triple baseline immunosuppression including cyclosporine A.

1988 • 3 citations

Adjunctive azathioprine and antilymphocyte serum immunosuppression with cyclosporine.

1988 • 2 citations

Rejection prophylaxis with murine monoclonal CD-3 antibody (OKT3): considerations for early hospital discharge.

1989 • 2 citations