Hepatic lipase and HDL metabolism

Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor

1996 • 2,293 citations

High density lipoprotein metabolism.

1984 • 1,230 citations

INTERFACIAL ENZYME KINETICS OF LIPOLYSIS

1976 • 573 citations

Evidence for the role of hepatic endothelial lipase in the metabolism of plasma high density lipoprotein2 in man

1980 • 335 citations

Remodelling of high density lipoproteins by plasma factors

1999 • 273 citations

Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL particle size. Effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution.

1994 • 266 citations

On the metabolic function of heparin-releasable liver lipase

1980 • 250 citations

Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics.

1993 • 239 citations

Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.

1994 • 236 citations

Mild Dyslipidemia in Mice following Targeted Inactivation of the Hepatic Lipase Gene

1995 • 199 citations

Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase.

1988 • 184 citations

Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Mediates the Cellular Internalization and Degradation of Thrombospondin

1995 • 181 citations

Localization of the heparin-releasable lipase in situ in the rat liver

1979 • 168 citations

Effect of serum and C‐apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

1976 • 165 citations

Studies on the metabolic mechanism of reduced high density lipoproteins during anabolic steroid therapy

1983 • 162 citations

Lipoprotein metabolism in hepatic lipase deficiency: studies on the turnover of apolipoprotein B and on the effect of hepatic lipase on high density lipoprotein.

1988 • 155 citations

Hepatic lipase

1999 • 147 citations

Human hepatic triglyceride lipase expression reduces high density lipoprotein and aortic cholesterol in cholesterol-fed transgenic mice.

1994 • 143 citations

Large buoyant LDL-like particles in hepatic lipase deficiency.

1989 • 142 citations

Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol.

1993 • 136 citations

Postheparin plasma lipoprotein and hepatic lipase are determinants of hypo- and hyperalphalipoproteinemia.

1989 • 130 citations

Mechanism of the hepatic lipase-induced accumulation of high-density lipoprotein cholesterol by cells in culture

1985 • 128 citations

Oral Estrogen Replacement Therapy in Postmenopausal Women Selectively Raises Levels and Production Rates of Lipoprotein A-I and Lowers Hepatic Lipase Activity Without Lowering the Fractional Catabolic Rate

1996 • 128 citations

Plasma lipoproteins in familial hepatic lipase deficiency.

1990 • 126 citations

The Cellular Internalization and Degradation of Hepatic Lipase Is Mediated by Low Density Lipoprotein Receptor-related Protein and Requires Cell Surface Proteoglycans

1995 • 123 citations

Postheparin plasma triglyceride lipases. Relationships with very low density lipoprotein triglyceride and high density lipoprotein2 cholesterol.

1985 • 122 citations

Deficiency of Hepatic Lipase Activity in Post‐heparin Plasma in Familial Hyper‐α‐Triglyceridemia

1986 • 117 citations

Hepatic Lipase Deficiency Increases Plasma Cholesterol but Reduces Susceptibility to Atherosclerosis in Apolipoprotein E-deficient Mice

1997 • 115 citations

Hepatic lipase promotes the selective uptake of high density lipoprotein-cholesteryl esters via the scavenger receptor B1

1999 • 112 citations

The dyslipoproteinemia of anabolic steroid therapy: Increase in hepatic triglyceride lipase precedes the decrease in high density lipoprotein2 cholesterol

1987 • 105 citations

A Docking Receptor for HDL Cholesterol Esters

1996 • 96 citations

Lipoproteins are substrates for human secretory group IIA phospholipase A2: preferential hydrolysis of acute phase HDL

1998 • 89 citations

Hepatic lipase is abundant on both hepatocyte and endothelial cell surfaces in the liver

1997 • 87 citations

Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell line

1987 • 87 citations

Triacylglycerol and phospholipid hydrolysis in human plasma lipoproteins: role of lipoprotein and hepatic lipase

1992 • 77 citations

In vitro activation of the enzymic activity of hepatic lipase by apoA-II

1981 • 72 citations

Role of apolipoprotein E in hepatic lipase-catalyzed hydrolysis of phospholipid in high-density lipoproteins

1992 • 70 citations

Hepatic lipase hydrolysis of lipid monolayers. Regulation by apolipoproteins.

1991 • 70 citations

Effect of apolipoproteins on the hepatic lipase-catalyzed hydrolysis of human plasma high density lipoprotein2-triacylglycerols.

1982 • 64 citations

Hepatic lipase facilitates the selective uptake of cholesteryl esters from remnant lipoproteins in apoE-deficient mice

1998 • 64 citations

ApoA-II maintains HDL levels in part by inhibition of hepatic lipase: studies in apoA-II and hepatic lipase double knockout mice

1999 • 63 citations

Effect of apolipoproteins on the hepatic lipase-catalyzed hydrolysis of human plasma high density lipoprotein2-triacylglycerols

1982 • 55 citations

Selective uptake of high-density lipoprotein–associated cholesteryl esters by human hepatocytes in primary culture

1994 • 52 citations

Relationship between Post-Heparin Plasma Lipases, Triglycerides and High Density Lipoproteins in Normal Subjects

1990 • 51 citations

Action of lipoprotein lipase on phospholipid monolayers. Activation by apolipoprotein C-II

1983 • 51 citations

On the substrate specificity of rat liver phospholipase A1.

1988 • 38 citations

Overexpression of Human Hepatic Lipase and ApoE in Transgenic Rabbits Attenuates Response to Dietary Cholesterol and Alters Lipoprotein Subclass Distributions

1999 • 36 citations

Mechanism of Inhibition of Hepatic Triglyceride Lipase from Human Postheparin Plasma by Apolipoproteins A-I and A-II1

1982 • 31 citations

Remnant High Density Lipoprotein₂ Particles Produced by Hepatic Lipase Display High-Affinity Binding and Increased Endocytosis into a Human Hepatoma Cell Line (HEPG₂)

1998 • 29 citations

Activation of hepatic lipase catalyzed phosphatidylcholine hydrolysis by apolipoprotein E

1991 • 27 citations

Hepatic lipase mediates an increase in selective uptake of high-density lipoprotein-associated cholesteryl esters by human Hep 3B hepatoma cells in culture

1998 • 24 citations

[30] Purification and substrate specificity of rat hepatic lipase

1991 • 20 citations

Diacylglycerol is the preferred substrate in high density lipoproteins for human hepatic lipase

1997 • 17 citations

Hepatic triglyceride lipase promotes low density lipoprotein receptor-mediated catabolism of very low density lipoproteins in vitro

1999 • 15 citations

Hydrolysis of Phosphatidylcholine by Hepatic Lipase in Discoidal and Spheroidal Recombinant High-Density Lipoprotein

1997 • 9 citations