Bioactivation and covalent binding of halothane to liver macromolecules.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

1949 • 16,078 citations

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

A procedure for the isolation of deoxyribonucleic acid from micro-organisms

1961 • 11,554 citations

A METHOD FOR THE DETERMINATION OF DESOXYRIBONUCLEIC ACID, RIBONUCLEIC ACID, AND PHOSPHOPROTEINS IN ANIMAL TISSUES

1945 • 2,606 citations

Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

1973 • 2,275 citations

[99] Determination of nucleic acids in tissues by pentose analysis

1957 • 1,906 citations

Nuclei from Rat Liver: Isolation Method That Combines Purity with High Yield

1966 • 1,687 citations

DETERMINATION OF NUCLEIC ACIDS IN ANIMAL TISSUES

1955 • 1,260 citations

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.

1973 • 1,174 citations

The Determination of Nucleic Acids

1966 • 1,109 citations

[53] Quantitative and qualitative analysis of lipids and lipid components

1969 • 559 citations

Toxic liver injury and carcinogenesis. Methylation of rat-liver nucleic acids by dimethylnitrosamine in vivo

1962 • 399 citations

Birth Defects among Children of Nurse-anesthetists

1974 • 399 citations

Possible Mechanism of Liver Necrosis Caused by Aromatic Organic Compounds

1971 • 382 citations

Acetaminophen-Induced Hepatic Necrosis V. Correlation of Hepatic Necrosis, Covalent Binding and Glutathione Depletion in Hamsters

1974 • 303 citations

A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity—I correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity

1974 • 225 citations

Recurrent Hepatitis Attributable to Halothane Sensitization in an Anesthetist

1969 • 210 citations

Isolation of deoxyribonucleic acid from mammalian tissues

1967 • 192 citations

Morphological Changes in Livers of Rats Fed Polychlorinated Biphenyls

1972 • 182 citations

Chloroform toxicity in mice: Correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules

1973 • 177 citations

Halothane Biotransformation in Man

1967 • 159 citations

Urinary Metabolites of Halothane in Man

1975 • 156 citations

Bromobenzene Metabolism and Hepatic Necrosis

1971 • 141 citations

Studies on DNA repair in human lymphocytes treated with proximate carcinogens and alkylating agents.

1971 • 127 citations

ANGIOSARCOMA OF THE LIVER IN A VINYL-CHLORIDE WORKER

1974 • 126 citations

Mechanisms of Acute Hepatic Toxicity

1974 • 117 citations

Liver parenchymal cell injury. IV. Pattern of incorporation of carbon and chlorine from carbon tetrachloride into chemical constituents of liver in vivo.

1967 • 115 citations

Metabolism of volatile anasthetics—I

1964 • 114 citations

Hypoxia and Halothane Metabolism in Vivo

1976 • 107 citations

Metabolic activation of halothane and its covalent binding to liver endoplasmic proteins in vitro

1973 • 105 citations

Persistent binding of 2-acetylaminofluorene to rat liver DNA in vivo and consideration of the mechanism of binding of N-hydroxy-2-acetylaminofluorene to rat liver nucleic acids.

1969 • 100 citations

HALOTHANE HEPATITIS IN AN ANqSTHETIST

1966 • 91 citations

Covalent interaction of metabolites of the carcinogen trichloroethylene in rat hepatic microsomes.

1976 • 81 citations

Lipid peroxidation and alteration of membrane lipids in isolated hepatocytes exposed to carbon tetrachloride.

1976 • 79 citations

An Animal Model of Hepatotoxicity Associated with Halothane Anesthesia

1976 • 70 citations

Hepatic Microsomal Lipoperoxidation and Inhalation Anesthetics

1972 • 67 citations

Rat liver microsomes catalyse covalent binding of 14C-vinyl chloride to macromolecules

1975 • 64 citations

Metabolic activation of aromatic hydrocarbons in purified rat liver nuclei: induction of enzyme activities and binding to DNA with and without monooxygenase-catalyzed formation of active oxygen.

1976 • 60 citations

Mutagenicity of Volatile Anesthetics

1976 • 54 citations

Lymphocyte Transformation

1973 • 43 citations

Studies on irreversible binding of radioactivity from (14C)halothane to rat hepatic microsomal lipids and protein.

1974 • 42 citations

N-demethylation as an example of drug metabolism in isolated rat hepatocytes

1976 • 36 citations

Halothane Hepatotoxicity

1977 • 33 citations

Lipid binding of a halothane metabolite. Relationship to lipid peroxidation in vitro.

1976 • 31 citations

AN ANIMAL MODEL OF HEPATOTOXICITY ASSOCIATED WITH HALOTHANE ANESTHESIA

1978 • 30 citations

A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat

1977 • 20 citations

Failure to Induce Hepatic Pathology in Animals Sensitizedto a Halothane Metabolite and Subsequently Challenged with Halothane

1976 • 16 citations

What is a "Safe" Interval Between Halothane Exposures?

1972 • 10 citations

The effect of high concentration of halothane on the isolated perfused bovine liver.

1966 • 8 citations

Anesthetics and Cancer

1976 • 5 citations

Lipid binding of a halothane metabolite. Relationship to lipid peroxidation in vitro.

1976 • 4 citations