In vitro antibody response of human lymphocytes

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG.

1977 • 1,205 citations

Separation of functional subsets of human T cells by a monoclonal antibody.

1979 • 1,062 citations

Genes and Antibodies

1959 • 675 citations

A Monoclonal Antibody with Selective Reactivity with Functionally Mature Human Thymocytes and All Peripheral Human T Cells

1979 • 456 citations

Expression of a receptor for IgM by human T cells in vitro

1975 • 444 citations

Subpopulations of Human T Cells Identified by Receptors for Immunoglobulins and Mitogen Responsiveness

1976 • 430 citations

Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition.

1978 • 424 citations

Immunoregulatory Aberrations in Systemic Lupus Erythematosus

1978 • 359 citations

Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.

1978 • 296 citations

Evidence for the clonal abortion theory of B-lymphocyte tolerance.

1975 • 293 citations

Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells

1975 • 292 citations

Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc receptors

1978 • 274 citations

AGAMMAGLOBULINÆMIA WITH B LYMPHOCYTES SPECIFIC DEFECT OF PLASMA-CELL DIFFERENTIATION

1971 • 248 citations

Abnormalities of Immunoregulatory T Cells in Disorders of Immune Function

1979 • 220 citations

HL-A LD (Lymphocyte Defined) Typing: A Rapid Assay with Primed Lymphocytes

1975 • 212 citations

Autoimmunity in a rural community.

1972 • 207 citations

Familial Abnormalities of Suppressor-Cell Function in Systemic Lupus Erythematosus

1979 • 206 citations

Two Functionally Distinct Subpopulations of Human T Cells That Collaborate in the Generation of Cytotoxic Cells Responsible for Cell-Mediated Lympholysis

1978 • 206 citations

Characterization of a Circulating Subpopulation of Spontaneous Antitetanus Toxoid Antibody Producing B Cells Following in Vivo Booster Immunization

1979 • 201 citations

Increased spontaneous activity of antibody‐forming cells in the peripheral blood of patients with active sle

1977 • 197 citations

EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS: CELLULAR AND HUMORAL IMMUNE RESPONSES*

1976 • 185 citations

Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.

1978 • 172 citations

A subpopulation of normal human peripheral B lymphcytes that bind IgE.

1977 • 169 citations

Studies of Immune Functions of Patients with Systemic Lupus Erythematosus

1979 • 166 citations

Characterization of a Suppressor-Cell Leukemia

1978 • 160 citations

Proliferation of Tγ Cells with Killer-Cell Activity in Two Patients with Neutropenia and Recurrent Infections

1980 • 138 citations

A Receptor for IgA on Human T Lymphocytes

1979 • 137 citations

Induction and separation of antigen-dependent T helper and T suppressor cells in man

1978 • 136 citations

Isolation and Characterization of Naturally Occurring Subclasses of Human Peripheral Blood T Cells with Regulatory Functions

1978 • 135 citations

Nicotinic acetylcholine receptor: evidence for a functionally distinct receptor on human lymphocytes.

1979 • 125 citations

INTERACTION OF HUMAN THYMUS-DERIVED AND NON-THYMUS-DERIVED LYMPHOCYTES IN VITRO

1973 • 122 citations

An improved assay for haemolytic plaque-forming cells.

1971 • 113 citations

Suppressor-Cell Antibody in Systemic Lupus Erythematosus

1979 • 112 citations

Generation of Human Plaque-Forming Cells in Culture: Tissue Distribution, Antigenic and Cellular Requirements

1977 • 100 citations

A Third Signal in B Cell Activation Given by TRF

1975 • 95 citations

Studies of immune functions of patients with systemic lupus erythematosus. T-cell subsets and antibodies to T-cell subsets.

1979 • 91 citations

Subpopulations of human T lymphocytes. I. Studies in immunodeficient patients.

1977 • 87 citations

Localization of human antigen-specific helper and suppressor function in distinct T-cell subpopulations

1979 • 85 citations

Subpopulations of human T lymphocytes

1978 • 81 citations

TOLERANCE TO AN AUTOANTIGENTHYROGLOBULIN Antigen-binding Lymphocytes in Thymus and Blood in Health and Autoimmune Disease

1973 • 81 citations

Regulation of B Cell Activity in Man: Role of T Cells

1979 • 76 citations

PRIMARY IN VITRO ANTIBODY RESPONSE FROM HUMAN PERIPHERAL BLOOD LYMPHOCYTES

1977 • 70 citations

A serum inhibitor of immune regulation in patients with systemic lupus erythematosus.

1978 • 70 citations

Regulation of immunoglobulin production in human peripheral bood leukocytes: cellular interactions.

1977 • 68 citations

Suppression of B lymphocyte differentiation by newborn T lymphocytes with an Fc receptor for IgM.

1978 • 67 citations

Suppressor cell induction in vitro

1977 • 66 citations

Induction of antigen-specific human suppressor T lymphocytes in vitro

1978 • 66 citations

Activation of human B lymphocytes. X. Heterogeneity of concanavalin A-generated suppressor cells of the pokeweed mitogen-induced plaque-forming cell response of human peripheral blood lymphocytes.

1978 • 66 citations

Identification of Two Serum Components Regulating the Expression of T-Lymphocyte Function in Childhood Myasthenia Gravis

1979 • 65 citations

Changes of Fcgamma receptor-related properties induced by interaction of human lymphocytes with insoluble immune complexes.

1977 • 64 citations

In vitro induction and measurement of hemolytic plaque forming cells in man

1976 • 59 citations

Phenotypic and Functional Distinctions between the TH2+ and JRA+ T Cell Subsets in Man

1979 • 58 citations

Antigen-specific helper factor in man.

1978 • 58 citations

Anti DNA antibody production by lymphoid cells of mice and human systemic lupus erythematosus (SLE)

1973 • 55 citations

Detection of Plaque-Forming Cells in the Peripheral Blood of Actively Immunized Humans

1977 • 53 citations

Differential synthesis of IgM and IgG anti-tetanus toxoid antibody in vitro following in vivo booster immunization of humans

1979 • 53 citations

T-T Interactions in the Induction of Antigen-Specific Human Suppressor T Lymphocytes in Vitro

1979 • 41 citations

Primary sensitisation and restimulation of human lymphocytes with soluble antigen in vitro

1979 • 31 citations

Maturation of b lymphocytes in rates. III. Two subpopulations of memory B cells in the thoracic duct lymph differ by size, turnover rate, and surface immunoglobulin.

1976 • 30 citations

The production of a soluble human T-lymphocyte derived factor which substitutes for helper T lymphocytes in the in vitro production of immunoglobulin.

1979 • 30 citations

Activation of human B lymphocytes. XIII. Characterization of multiple populations of naturally occurring immunoregulatory cells of polyclonally induced in vitro human B cell function.

1979 • 30 citations

Induction of human antigen-specific and non-specific helper factors in vitro.

1979 • 28 citations

Activation of human B lymphocytes. IX. Modulation of antibody production by products of activated macrophages.

1978 • 26 citations

Primary in vitro sensitisation of human T cells

1977 • 25 citations

Systemic Lupus Erythematosus, Autoimmunity, Sex and Inheritance

1979 • 25 citations

Feedback inhibition by human primed T-helper cells

1979 • 24 citations

Experimental allergic encephalomyelitis: its production, prevention, and pathology as studied by light and electron microscopy.

1959 • 23 citations

Lymphocyte Function in Rheumatic Disorders

1975 • 21 citations

Control of the Immune System by Inhibitor and Inducer T Lymphocytes

1979 • 21 citations

Antibody production and DNA synthesis of human lymphocyte subpopulations induced by PPD tuberculin.

1979 • 20 citations

The physiological regulation of immunity: Differential regulatory contributions of peripheral and central lymphon compartments

1979 • 19 citations

Alloantibodies that React with Subsets of Human T Cells

1979 • 15 citations

Receptors for IgM on human lymphocytes. I. Detection of receptors on freshly drawn lymphocytes and at physiological temperature

1979 • 15 citations

Activation of antibody synthesis in human B lymphocytes

1979 • 14 citations

AUTOIMMUNE DISEASE AND THE THEORY OF CLONAL ABORTION

1979 • 13 citations

Human T lymphocyte receptors for IgM: control by IgG‐binding lymphocytes

1979 • 13 citations

The effect of antigen on the output of recirculating T and B lymphocytes from single lymph nodes

1978 • 12 citations

Specific immune response enhancing factor in serum of immunised mice

1978 • 11 citations

Transition in the Character of Immunological Memory in Mice after Immunization

1976 • 10 citations

Rabbit lymphocytes with receptors for IgM

1979 • 10 citations

Transition in the Character of Immunological Memory in Mice after Immunization

1976 • 9 citations

Association of helper activity for B-lymphocyte differentiation with lymphocytes having both SRBC and complement receptors in a patient with lymphoproliferative disease

1979 • 8 citations

DISTINCT HUMAN T-CELL SUBPOPULATIONS REGULATING THE ANTIGEN-INDUCED ANTIBODY RESPONSE

1979 • 7 citations

HUMAN B-CELL ACTIVATION IN VITRO: REGULATION BY ANTIGEN-SPECIFIC HUMAN SUPPRESSOR T CELLS

1979 • 7 citations

Induction of Antibody Responses In Vivo by Antigen Specific Helper Factor

1979 • 6 citations

Delineation of IgM-receptor bearing human T and B lymphocytes using a direct plaque forming cell (PFC) assay

1979 • 3 citations

INDUCTION OF ANTIBODY SYNTHESIS IN HUMAN LYMPHOCYTES FROM DIFFERENT ORGANS BY DIFFERENT PBA SUBSTANCES

1979 • 3 citations

HUMAN B CELL ACTIVATION IN VITRO: ANTIGEN-SPECIFIC HELPER AND SUPPRESSOR EFFECTS ARE MEDIATED BY DISTINCT T CELL SUBPOPULATIONS

1979 • 2 citations

HUMAN ANTIGEN SPECIFIC HELPER T CELL FACTORS IN B CELL RESPONSES

1979 • 1 citations